FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221022255> ?p ?o ?g. }

• W4221022255 abstract "Abstract A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin modification. The 14q32 locus contains many non-coding RNAs such as Maternally Expressed Gene 8 (MEG8). We observed an induction of this gene in ischemic heart disease. We investigated the role of MEG8 specifically in endothelial function as well as the underlying mechanism. We hypothesized that MEG8 plays an important role in cardiovascular disease via epigenetic regulation of gene expression. Experiments were performed in human umbilical vein endothelial cells (HUVECs). In vitro silencing of MEG8 resulted in impaired angiogenic sprouting. More specifically, total sprout length was reduced as was proliferation, while migration was unaffected. We performed RNA sequencing to assess changes in gene expression after loss of MEG8. The most profoundly regulated gene, Tissue Factor Pathway Inhibitor 2 (TFPI2), was fivefold increased following MEG8 silencing. TFPI2 has previously been described as an inhibitor of angiogenesis. Mechanistically, MEG8 silencing resulted in a reduction of the inhibitory histone modification H3K27me3 at the TFPI2 promoter. Interestingly, additional silencing of TFPI2 partially restored angiogenic sprouting capacity but did not affect proliferation of MEG8 silenced cells. In conclusion, silencing of MEG8 impairs endothelial function, suggesting a potential beneficial role in maintaining cell viability. Our study highlights the MEG8/TFPI2 axis as potential therapeutic approach to improve angiogenesis following ischemia." @default.
• W4221022255 created "2022-04-03" @default.
• W4221022255 creator A5016611690 @default.
• W4221022255 creator A5017256014 @default.
• W4221022255 creator A5019942908 @default.
• W4221022255 creator A5026789610 @default.
• W4221022255 creator A5038168057 @default.
• W4221022255 creator A5059802318 @default.
• W4221022255 creator A5060386315 @default.
• W4221022255 creator A5065295646 @default.
• W4221022255 creator A5069687563 @default.
• W4221022255 date "2022-01-17" @default.
• W4221022255 modified "2023-10-17" @default.
• W4221022255 title "MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium" @default.
• W4221022255 cites W1842333848 @default.
• W4221022255 cites W1968228591 @default.
• W4221022255 cites W1992770651 @default.
• W4221022255 cites W2006856548 @default.
• W4221022255 cites W2014093464 @default.
• W4221022255 cites W2033586326 @default.
• W4221022255 cites W2041816417 @default.
• W4221022255 cites W2046195556 @default.
• W4221022255 cites W2060608189 @default.
• W4221022255 cites W2066010739 @default.
• W4221022255 cites W2074196937 @default.
• W4221022255 cites W2079983771 @default.
• W4221022255 cites W2081065930 @default.
• W4221022255 cites W2095131091 @default.
• W4221022255 cites W2104857427 @default.
• W4221022255 cites W2126047917 @default.
• W4221022255 cites W2129528305 @default.
• W4221022255 cites W2131271579 @default.
• W4221022255 cites W2138207763 @default.
• W4221022255 cites W2138585067 @default.
• W4221022255 cites W2146519773 @default.
• W4221022255 cites W2148743089 @default.
• W4221022255 cites W2163802438 @default.
• W4221022255 cites W2169456326 @default.
• W4221022255 cites W2169524380 @default.
• W4221022255 cites W2179438025 @default.
• W4221022255 cites W2330725315 @default.
• W4221022255 cites W2558026400 @default.
• W4221022255 cites W2560838306 @default.
• W4221022255 cites W2583201785 @default.
• W4221022255 cites W2609409873 @default.
• W4221022255 cites W2765241643 @default.
• W4221022255 cites W2808173735 @default.
• W4221022255 cites W2894315454 @default.
• W4221022255 cites W2897734852 @default.
• W4221022255 cites W2901487099 @default.
• W4221022255 cites W2911137144 @default.
• W4221022255 cites W2945535530 @default.
• W4221022255 cites W2952247549 @default.
• W4221022255 cites W2985288725 @default.
• W4221022255 cites W3018954054 @default.
• W4221022255 cites W3033791775 @default.
• W4221022255 cites W3040078423 @default.
• W4221022255 cites W3101655471 @default.
• W4221022255 cites W3119781280 @default.
• W4221022255 cites W4256530495 @default.
• W4221022255 doi "https://doi.org/10.1038/s41598-022-04812-z" @default.
• W4221022255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35039572" @default.
• W4221022255 hasPublicationYear "2022" @default.
• W4221022255 type Work @default.
• W4221022255 citedByCount "6" @default.
• W4221022255 countsByYear W42210222552022 @default.
• W4221022255 countsByYear W42210222552023 @default.
• W4221022255 crossrefType "journal-article" @default.
• W4221022255 hasAuthorship W4221022255A5016611690 @default.
• W4221022255 hasAuthorship W4221022255A5017256014 @default.
• W4221022255 hasAuthorship W4221022255A5019942908 @default.
• W4221022255 hasAuthorship W4221022255A5026789610 @default.
• W4221022255 hasAuthorship W4221022255A5038168057 @default.
• W4221022255 hasAuthorship W4221022255A5059802318 @default.
• W4221022255 hasAuthorship W4221022255A5060386315 @default.
• W4221022255 hasAuthorship W4221022255A5065295646 @default.
• W4221022255 hasAuthorship W4221022255A5069687563 @default.
• W4221022255 hasBestOaLocation W42210222551 @default.
• W4221022255 hasConcept C104317684 @default.
• W4221022255 hasConcept C119056186 @default.
• W4221022255 hasConcept C150194340 @default.
• W4221022255 hasConcept C153911025 @default.
• W4221022255 hasConcept C165864922 @default.
• W4221022255 hasConcept C22615655 @default.
• W4221022255 hasConcept C2780394083 @default.
• W4221022255 hasConcept C41091548 @default.
• W4221022255 hasConcept C54355233 @default.
• W4221022255 hasConcept C67705224 @default.
• W4221022255 hasConcept C86803240 @default.
• W4221022255 hasConcept C95444343 @default.
• W4221022255 hasConceptScore W4221022255C104317684 @default.
• W4221022255 hasConceptScore W4221022255C119056186 @default.
• W4221022255 hasConceptScore W4221022255C150194340 @default.
• W4221022255 hasConceptScore W4221022255C153911025 @default.
• W4221022255 hasConceptScore W4221022255C165864922 @default.
• W4221022255 hasConceptScore W4221022255C22615655 @default.
• W4221022255 hasConceptScore W4221022255C2780394083 @default.
• W4221022255 hasConceptScore W4221022255C41091548 @default.
• W4221022255 hasConceptScore W4221022255C54355233 @default.
• W4221022255 hasConceptScore W4221022255C67705224 @default.

• next