Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221022425> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4221022425 abstract "Neurological / neurovascular disorders constitute the leading cause of disability and second leading cause of deaths in the world. Some of the major neurological / neurovascular disorders or diseases include stroke, Alzheimer’s disease, spinal cord injury, neonatal hypoxic-ischemic encephalopathy, etc. Their pathophysiology is considered as highly complex and has been blamed as the main obstacle in the development of any drugs for these diseases. In this review, we have described the endothelin system, their involvement in neurovascular disorders, importance of endothelin B receptors (ETBRs) as a novel potential drug target, and its agonism by IRL-1620 (INN - sovateltide), which we are developing as a drug candidate for treating the above-mentioned neurological disorders / diseases. We have highlighted the results of our pre-clinical and clinical studies related to these diseases. The phase I, safety and tolerability study of sovateltide has shown it as a highly safe and well tolerable compound at tested dosages, while pre-clinical and clinical phase II studies have demonstrated its efficacy in treating acute ischemic stroke, where it is currently being developed as a “First in Class” drug. Its testing in Alzheimer’s disease (AD), acute spinal cord injury and neonatal hypoxic-ischemic encephalopathy (HIE) is currently being carried out and are at different stages of drug development. Successful completion of these studies will prove the involvement of ETBRs signaling in neurological / neurovascular diseases and help in development of novel neurological drugs in future." @default.
- W4221022425 created "2022-04-03" @default.
- W4221022425 creator A5000625406 @default.
- W4221022425 creator A5039522776 @default.
- W4221022425 date "2022-03-10" @default.
- W4221022425 modified "2023-09-26" @default.
- W4221022425 title "Sovateltide Mediated Endothelin B Receptors Agonism and Curbing Neurological Disorders" @default.
- W4221022425 doi "https://doi.org/10.20944/preprints202203.0138.v1" @default.
- W4221022425 hasPublicationYear "2022" @default.
- W4221022425 type Work @default.
- W4221022425 citedByCount "0" @default.
- W4221022425 crossrefType "posted-content" @default.
- W4221022425 hasAuthorship W4221022425A5000625406 @default.
- W4221022425 hasAuthorship W4221022425A5039522776 @default.
- W4221022425 hasBestOaLocation W42210224251 @default.
- W4221022425 hasConcept C105572291 @default.
- W4221022425 hasConcept C126322002 @default.
- W4221022425 hasConcept C127413603 @default.
- W4221022425 hasConcept C142724271 @default.
- W4221022425 hasConcept C15744967 @default.
- W4221022425 hasConcept C169760540 @default.
- W4221022425 hasConcept C197934379 @default.
- W4221022425 hasConcept C2778375690 @default.
- W4221022425 hasConcept C2779134260 @default.
- W4221022425 hasConcept C2780645631 @default.
- W4221022425 hasConcept C60644358 @default.
- W4221022425 hasConcept C71924100 @default.
- W4221022425 hasConcept C78519656 @default.
- W4221022425 hasConcept C86803240 @default.
- W4221022425 hasConcept C98274493 @default.
- W4221022425 hasConceptScore W4221022425C105572291 @default.
- W4221022425 hasConceptScore W4221022425C126322002 @default.
- W4221022425 hasConceptScore W4221022425C127413603 @default.
- W4221022425 hasConceptScore W4221022425C142724271 @default.
- W4221022425 hasConceptScore W4221022425C15744967 @default.
- W4221022425 hasConceptScore W4221022425C169760540 @default.
- W4221022425 hasConceptScore W4221022425C197934379 @default.
- W4221022425 hasConceptScore W4221022425C2778375690 @default.
- W4221022425 hasConceptScore W4221022425C2779134260 @default.
- W4221022425 hasConceptScore W4221022425C2780645631 @default.
- W4221022425 hasConceptScore W4221022425C60644358 @default.
- W4221022425 hasConceptScore W4221022425C71924100 @default.
- W4221022425 hasConceptScore W4221022425C78519656 @default.
- W4221022425 hasConceptScore W4221022425C86803240 @default.
- W4221022425 hasConceptScore W4221022425C98274493 @default.
- W4221022425 hasLocation W42210224251 @default.
- W4221022425 hasOpenAccess W4221022425 @default.
- W4221022425 hasPrimaryLocation W42210224251 @default.
- W4221022425 hasRelatedWork W1774266184 @default.
- W4221022425 hasRelatedWork W2000456837 @default.
- W4221022425 hasRelatedWork W2049567231 @default.
- W4221022425 hasRelatedWork W2082482010 @default.
- W4221022425 hasRelatedWork W2146571284 @default.
- W4221022425 hasRelatedWork W2375863412 @default.
- W4221022425 hasRelatedWork W2409130183 @default.
- W4221022425 hasRelatedWork W2685228195 @default.
- W4221022425 hasRelatedWork W2765379856 @default.
- W4221022425 hasRelatedWork W2803551190 @default.
- W4221022425 isParatext "false" @default.
- W4221022425 isRetracted "false" @default.
- W4221022425 workType "article" @default.