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• W4221026085 startingPage "806" @default.
• W4221026085 abstract "Autism spectrum disorder (ASD), as a common neurodevelopmental disorder that encompasses impairments in social communication and interaction, as well as repetitive and restrictive behavior, still awaits an effective treatment strategy. The involvement of GABAergic neurotransmission, and especially a deficit of GABAA receptors that contain the α5 subunits, were implicated in pathogenesis of ASD. Therefore, we tested MP-III-022, a positive allosteric modulator (PAM) selective for α5GABAA receptors, in Wistar rats prenatally exposed to valproic acid, as an animal model useful for studying ASD. Postweaning rats of both sexes were treated for 7 days with vehicle or MP-III-022 at two doses pharmacokinetically determined as selective, and thereafter tested in a behavioral battery (social interaction test, elevated plus maze, spontaneous locomotor activity, and standard and reverse Morris water maze). Additional rats were used for establishing a primary neuronal culture and performing calcium imaging, and determination of hippocampal mRNA levels of GABRA5, NKCC1, and KCC2. MP-III-022 prevented impairments in many parameters connected with social, repetitive and restrictive behavioral domains. The lower and higher dose was more effective in males and females, respectively. Intriguingly, MP-III-022 elicited certain changes in control animals similar to those manifested in valproate animals themselves. Behavioral results were mirrored in GABA switch and spontaneous neuronal activity, assessed with calcium imaging, and also in expression changes of three genes analyzed. Our data support a role of α5GABAA receptors in pathophysiology of ASD, and suggest a potential application of selective PAMs in its treatment, that needs to be researched in a sex-specific manner. LAY SUMMARY: In rats prenatally exposed to valproate as a model of autism, a modulator of α5GABAA receptors ameliorated social, repetitive and restrictive impairments, and, intriguingly, elicited certain autism-like changes in control rats. Behavioral results were mirrored in GABA switch and spontaneous neuronal activity, and partly in gene expression changes. This shows a role of α5GABAA receptors in pathophysiology of ASD, and a potential application of their selective modulators in its treatment." @default.
• W4221026085 created "2022-04-03" @default.
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• W4221026085 date "2022-03-10" @default.
• W4221026085 modified "2023-10-17" @default.
• W4221026085 title "Postweaning positive modulation of <scp>α5GABAA</scp> receptors improves autism‐like features in prenatal valproate rat model in a sex‐specific manner" @default.
• W4221026085 cites W1488489801 @default.
• W4221026085 cites W1588629441 @default.
• W4221026085 cites W1821749400 @default.
• W4221026085 cites W1970008729 @default.
• W4221026085 cites W1970564794 @default.
• W4221026085 cites W1983637632 @default.
• W4221026085 cites W2003540539 @default.
• W4221026085 cites W2005585817 @default.
• W4221026085 cites W2005822031 @default.
• W4221026085 cites W2012980780 @default.
• W4221026085 cites W2014310721 @default.
• W4221026085 cites W2023794469 @default.
• W4221026085 cites W2027260549 @default.
• W4221026085 cites W2027468762 @default.
• W4221026085 cites W2030259672 @default.
• W4221026085 cites W2033856668 @default.
• W4221026085 cites W2035027696 @default.
• W4221026085 cites W2040717681 @default.
• W4221026085 cites W2048824131 @default.
• W4221026085 cites W2053154721 @default.
• W4221026085 cites W2053909439 @default.
• W4221026085 cites W2057338363 @default.
• W4221026085 cites W2066521976 @default.
• W4221026085 cites W2076161982 @default.
• W4221026085 cites W2077741292 @default.
• W4221026085 cites W2080984518 @default.
• W4221026085 cites W2084615635 @default.
• W4221026085 cites W2087505388 @default.
• W4221026085 cites W2089020381 @default.
• W4221026085 cites W2091486815 @default.
• W4221026085 cites W2092239688 @default.
• W4221026085 cites W2098251401 @default.
• W4221026085 cites W2098490628 @default.
• W4221026085 cites W2099166543 @default.
• W4221026085 cites W2102329408 @default.
• W4221026085 cites W2108916755 @default.
• W4221026085 cites W2110143479 @default.
• W4221026085 cites W2124430429 @default.
• W4221026085 cites W2128978319 @default.
• W4221026085 cites W2132482152 @default.
• W4221026085 cites W2138788537 @default.
• W4221026085 cites W2140655650 @default.
• W4221026085 cites W2144882747 @default.
• W4221026085 cites W2159437054 @default.
• W4221026085 cites W2167825772 @default.
• W4221026085 cites W2244443776 @default.
• W4221026085 cites W2295306763 @default.
• W4221026085 cites W2305304932 @default.
• W4221026085 cites W2336973322 @default.
• W4221026085 cites W2338677800 @default.
• W4221026085 cites W2386643948 @default.
• W4221026085 cites W2511577082 @default.
• W4221026085 cites W2518842266 @default.
• W4221026085 cites W2526069923 @default.
• W4221026085 cites W2542668511 @default.
• W4221026085 cites W2553022533 @default.
• W4221026085 cites W2570871696 @default.
• W4221026085 cites W2623899914 @default.
• W4221026085 cites W2624152629 @default.
• W4221026085 cites W2751298042 @default.
• W4221026085 cites W2784028610 @default.
• W4221026085 cites W2790415996 @default.
• W4221026085 cites W2808426286 @default.
• W4221026085 cites W2888120889 @default.
• W4221026085 cites W2890169762 @default.
• W4221026085 cites W2944853932 @default.
• W4221026085 cites W2960913096 @default.
• W4221026085 cites W2966607193 @default.
• W4221026085 cites W2985222552 @default.
• W4221026085 cites W3020796518 @default.
• W4221026085 cites W3062447560 @default.
• W4221026085 cites W3201043803 @default.
• W4221026085 cites W4210708461 @default.
• W4221026085 cites W4247665917 @default.
• W4221026085 cites W4249656656 @default.
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• W4221026085 doi "https://doi.org/10.1002/aur.2699" @default.
• W4221026085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35266641" @default.
• W4221026085 hasPublicationYear "2022" @default.
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