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- W4221026585 abstract "Protein fibrillation leads to formation of amyloids-linear aggregates that are hallmarks of many serious diseases, including Alzheimer's and Parkinson's diseases. In this work, we investigate the fibrillation of a short peptide (K-peptide) from the amyloidogenic core of hen egg white lysozyme in the presence of dimethyl sulfoxide or urea. During the studies, a variety of spectroscopic methods were used: fluorescence spectroscopy and the Thioflavin T assay, circular dichroism, Fourier-transform infrared spectroscopy, optical density measurements, dynamic light scattering and intrinsic fluorescence. Additionally, the presence of amyloids was confirmed by atomic force microscopy. The obtained results show that the K-peptide is highly prone to form fibrillar aggregates. The measurements also confirm the weak impact of dimethyl sulfoxide on peptide fibrillation and distinct influence of urea. We believe that the K-peptide has higher amyloidogenic propensity than the whole protein, i.e., hen egg white lysozyme, most likely due to the lack of the first step of amyloidogenesis-partial unfolding of the native structure. Urea influences the second step of K-peptide amyloidogenesis, i.e., folding into amyloids." @default.
- W4221026585 created "2022-04-03" @default.
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- W4221026585 date "2022-03-11" @default.
- W4221026585 modified "2023-10-15" @default.
- W4221026585 title "Influence of Urea and Dimethyl Sulfoxide on K-Peptide Fibrillation" @default.
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- W4221026585 doi "https://doi.org/10.3390/ijms23063027" @default.
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- W4221026585 hasPublicationYear "2022" @default.
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