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- W4221026952 abstract "We hypothesized that Lomecel-B, an allogeneic medicinal signaling cell (MSC) therapeutic candidate for Alzheimer's disease (AD), is safe and potentially disease-modifying via pleiotropic mechanisms of action.We prospectively tested the predictions that Lomecel-B administration to mild AD patients is safe (primary endpoint) and would provide multiple exploratory indications of potential efficacy in clinical and biomarker domains (prespecified secondary/exploratory endpoints).Mild AD patient received a single infusion of low- or high-dose Lomecel-B, or placebo, in a double-blind, randomized, phase I trial. The primary safety endpoint was met. Fluid-based and imaging biomarkers indicated significant improvement in the Lomecel-B arms versus placebo. The low-dose Lomecel-B arm showed significant improvements versus placebo on neurocognitive and other assessments.Our results support the safety of Lomecel-B for AD, suggest clinical potential, and provide mechanistic insights. This early-stage study provides important exploratory information for larger efficacy-powered clinical trials." @default.
- W4221026952 created "2022-04-03" @default.
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- W4221026952 date "2022-03-31" @default.
- W4221026952 modified "2023-10-01" @default.
- W4221026952 title "Results and insights from a phase I clinical trial of Lomecel‐B for Alzheimer's disease" @default.
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- W4221026952 cites W2008854521 @default.
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- W4221026952 doi "https://doi.org/10.1002/alz.12651" @default.
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