FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221027509> ?p ?o ?g. }

• W4221027509 endingPage "100619" @default.
• W4221027509 startingPage "100619" @default.
• W4221027509 abstract "Cervical cancer (CC) is a common tumor in the female reproductive tract. Circular RNA hsa_circ_0011385 has been reported to be up-regulated in CC tissues. Nevertheless, the role and regulatory mechanism of hsa_circ_0011385 in CC are still being further verified. The levels of hsa_circ_0011385, microRNA (miR)- 149-5p, and peroxiredoxin 6 (PRDX6) mRNA in CC samples and cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Loss-of-function experiments were performed to survey the impacts of hsa_circ_0011385 inhibition on CC cell proliferation, colony formation, cycle progression, apoptosis, metastasis, invasion, and angiogenesis. Protein levels were detected by western blotting. The relationship between hsa_circ_0011385 or PRDX6 and miR-149-5p was verified by dual-luciferase reporter, RNA immunoprecipitation (RIP), and/or RNA pull-down assays. The tumorigenesis role of hsa_circ_0011385 in CC was confirmed by xenograft assay. We observed that hsa_circ_0011385 and PRDX6 were up-regulated while miR-149-5p was down-regulated in CC samples and cell lines. CC patients with high hsa_circ_0011385 expression possessed a shorter overall survival. Hsa_circ_0011385 knockdown reduced tumor growth in vivo and facilitated apoptosis, cell cycle arrest, impeded proliferation, metastasis, invasion, and angiogenesis of CC cells in vitro. Hsa_circ_0011385 could mediate PRDX6 expression through binding to miR-149-5p. MiR-149-5p silencing reversed hsa_circ_0011385 knockdown-mediated effects on CC cell angiogenesis and malignancy. PRDX6 overexpression overturned the inhibitory effects of miR-149-5p overexpression on angiogenesis and malignant behaviors of CC cells. In conclusion, hsa_circ_0011385 accelerated angiogenesis and malignant behaviors of CC cells by regulating the miR-149-5p/PRDX6 axis, manifesting that hsa_circ_0011385 might be a therapeutic target for CC." @default.
• W4221027509 created "2022-04-03" @default.
• W4221027509 creator A5012816933 @default.
• W4221027509 creator A5017947172 @default.
• W4221027509 creator A5064613375 @default.
• W4221027509 creator A5071409182 @default.
• W4221027509 date "2022-06-01" @default.
• W4221027509 modified "2023-10-02" @default.
• W4221027509 title "Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149–5p and increasing PRDX6 expression" @default.
• W4221027509 cites W1977298095 @default.
• W4221027509 cites W1987350137 @default.
• W4221027509 cites W1995002748 @default.
• W4221027509 cites W2034882495 @default.
• W4221027509 cites W2073985190 @default.
• W4221027509 cites W2122412538 @default.
• W4221027509 cites W2130687298 @default.
• W4221027509 cites W2302185643 @default.
• W4221027509 cites W2341291028 @default.
• W4221027509 cites W2373378636 @default.
• W4221027509 cites W2795917193 @default.
• W4221027509 cites W2800376069 @default.
• W4221027509 cites W2805791927 @default.
• W4221027509 cites W2883286298 @default.
• W4221027509 cites W2884231755 @default.
• W4221027509 cites W2889646458 @default.
• W4221027509 cites W2898460463 @default.
• W4221027509 cites W2909184366 @default.
• W4221027509 cites W2910599425 @default.
• W4221027509 cites W2912017471 @default.
• W4221027509 cites W2920891134 @default.
• W4221027509 cites W2921882381 @default.
• W4221027509 cites W2954118205 @default.
• W4221027509 cites W2964331590 @default.
• W4221027509 cites W2967043226 @default.
• W4221027509 cites W2969971532 @default.
• W4221027509 cites W2985309965 @default.
• W4221027509 cites W2987445370 @default.
• W4221027509 cites W2989635070 @default.
• W4221027509 cites W3005722212 @default.
• W4221027509 cites W3012476305 @default.
• W4221027509 cites W3043543403 @default.
• W4221027509 cites W3043568153 @default.
• W4221027509 cites W3090292727 @default.
• W4221027509 doi "https://doi.org/10.1016/j.repbio.2022.100619" @default.
• W4221027509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35240453" @default.
• W4221027509 hasPublicationYear "2022" @default.
• W4221027509 type Work @default.
• W4221027509 citedByCount "6" @default.
• W4221027509 countsByYear W42210275092022 @default.
• W4221027509 countsByYear W42210275092023 @default.
• W4221027509 crossrefType "journal-article" @default.
• W4221027509 hasAuthorship W4221027509A5012816933 @default.
• W4221027509 hasAuthorship W4221027509A5017947172 @default.
• W4221027509 hasAuthorship W4221027509A5064613375 @default.
• W4221027509 hasAuthorship W4221027509A5071409182 @default.
• W4221027509 hasConcept C104317684 @default.
• W4221027509 hasConcept C119056186 @default.
• W4221027509 hasConcept C145059251 @default.
• W4221027509 hasConcept C153911025 @default.
• W4221027509 hasConcept C173396325 @default.
• W4221027509 hasConcept C185592680 @default.
• W4221027509 hasConcept C190232843 @default.
• W4221027509 hasConcept C190283241 @default.
• W4221027509 hasConcept C2780394083 @default.
• W4221027509 hasConcept C502942594 @default.
• W4221027509 hasConcept C55493867 @default.
• W4221027509 hasConcept C555283112 @default.
• W4221027509 hasConcept C62112901 @default.
• W4221027509 hasConcept C86803240 @default.
• W4221027509 hasConceptScore W4221027509C104317684 @default.
• W4221027509 hasConceptScore W4221027509C119056186 @default.
• W4221027509 hasConceptScore W4221027509C145059251 @default.
• W4221027509 hasConceptScore W4221027509C153911025 @default.
• W4221027509 hasConceptScore W4221027509C173396325 @default.
• W4221027509 hasConceptScore W4221027509C185592680 @default.
• W4221027509 hasConceptScore W4221027509C190232843 @default.
• W4221027509 hasConceptScore W4221027509C190283241 @default.
• W4221027509 hasConceptScore W4221027509C2780394083 @default.
• W4221027509 hasConceptScore W4221027509C502942594 @default.
• W4221027509 hasConceptScore W4221027509C55493867 @default.
• W4221027509 hasConceptScore W4221027509C555283112 @default.
• W4221027509 hasConceptScore W4221027509C62112901 @default.
• W4221027509 hasConceptScore W4221027509C86803240 @default.
• W4221027509 hasIssue "2" @default.
• W4221027509 hasLocation W42210275091 @default.
• W4221027509 hasLocation W42210275092 @default.
• W4221027509 hasOpenAccess W4221027509 @default.
• W4221027509 hasPrimaryLocation W42210275091 @default.
• W4221027509 hasRelatedWork W2041284866 @default.
• W4221027509 hasRelatedWork W2396483390 @default.
• W4221027509 hasRelatedWork W2473115738 @default.
• W4221027509 hasRelatedWork W2765489800 @default.
• W4221027509 hasRelatedWork W2770106509 @default.
• W4221027509 hasRelatedWork W2773673124 @default.
• W4221027509 hasRelatedWork W2887189912 @default.
• W4221027509 hasRelatedWork W2949158738 @default.
• W4221027509 hasRelatedWork W3145720896 @default.
• W4221027509 hasRelatedWork W4282967590 @default.

• next