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• W4221028379 abstract "Purpose To train and test a machine learning model to automatically measure mid-thigh muscle cross-sectional area (CSA) to provide rapid estimation of appendicular lean mass (ALM) and predict knee extensor torque of obese adults. Methods Obese adults [body mass index (BMI) = 30–40 kg/m 2 , age = 30–50 years] were enrolled for this study. Participants received full-body dual-energy X-ray absorptiometry (DXA), mid-thigh MRI, and completed knee extensor and flexor torque assessments via isokinetic dynamometer. Manual segmentation of mid-thigh CSA was completed for all MRI scans. A convolutional neural network (CNN) was created based on the manual segmentation to develop automated quantification of mid-thigh CSA. Relationships were established between the automated CNN values to the manual CSA segmentation, ALM via DXA, knee extensor, and flexor torque. Results A total of 47 obese patients were enrolled in this study. Agreement between the CNN-automated measures and manual segmentation of mid-thigh CSA was high (&gt;0.90). Automated measures of mid-thigh CSA were strongly related to the leg lean mass ( r = 0.86, p &lt; 0.001) and ALM ( r = 0.87, p &lt; 0.001). Additionally, mid-thigh CSA was strongly related to knee extensor strength ( r = 0.76, p &lt; 0.001) and moderately related to knee flexor strength ( r = 0.48, p = 0.002). Conclusion CNN-measured mid-thigh CSA was accurate compared to the manual segmented values from the mid-thigh. These values were strongly predictive of clinical measures of ALM and knee extensor torque. Mid-thigh MRI may be utilized to accurately estimate clinical measures of lean mass and function in obese adults." @default.
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• W4221028379 date "2022-03-24" @default.
• W4221028379 modified "2023-10-14" @default.
• W4221028379 title "Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults" @default.
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• W4221028379 doi "https://doi.org/10.3389/fresc.2022.808538" @default.
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