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- W4221029076 abstract "Oleaginous microalgae can produce triacylglycerol (TAG) under stress, yet the underlying mechanism remains largely unknown. Here, we show that, in Nannochloropsis oceanica, a bZIP-family regulator NobZIP77 represses the transcription of a type-2 diacylgycerol acyltransferase encoding gene NoDGAT2B under nitrogen-repletion (N+), while nitrogen-depletion (N-) relieves such inhibition and activates NoDGAT2B expression and synthesis of TAG preferably from C16:1. Intriguingly, NobZIP77 is a sensor of blue light (BL), which reduces binding of NobZIP77 to the NoDGAT2B-promoter, unleashes NoDGAT2B and elevates TAG under N-. Under N+ and white light, NobZIP77 knockout fully preserves cell growth rate and nearly triples TAG productivity. Moreover, exposing the NobZIP77-knockout line to BL under N- can double the peak productivity of TAG. These results underscore the potential of coupling light quality to oil synthesis in feedstock or bioprocess development." @default.
- W4221029076 created "2022-04-03" @default.
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- W4221029076 date "2022-03-29" @default.
- W4221029076 modified "2023-10-15" @default.
- W4221029076 title "Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica" @default.
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- W4221029076 doi "https://doi.org/10.1038/s41467-022-29337-x" @default.
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