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• W4221029628 abstract "Myosin is a motor enzyme that converts the chemical energy in ATP into mechanical work to drive a myriad of intracellular processes, from muscle contraction to vesicular transport. Key steps in the transduction of energy are the force-generating powerstroke, and the release of phosphate (Pi) from the nucleotide-binding site. Both events occur rapidly after binding to actin, making it difficult to determine which event occurs first. Early efforts suggested that these events occur simultaneously; however, recent findings indicate that they are separate and distinct events that occur at different rates. High-resolution crystal structures of myosin captured in intermediate states of the ATPase cycle suggest that when Pi is in the active site it prevents the powerstroke from occurring, leading to the hypothesis that Pi-release precedes the powerstroke. However, advances in functional assays, enabling sub-millisecond temporal and nanometer spatial resolution, are challenging this hypothesis. For example, Föster Resonance Energy Transfer (FRET) based assays, as well as single molecule laser trap assays, suggest the opposite; that the powerstroke occurs prior to the release of Pi from myosin's active site. This review provides some historical context and then highlights recent reports that reveal exciting new insight into this fundamental mechanism of energy transduction by this prototypical motor enzyme." @default.
• W4221029628 created "2022-04-03" @default.
• W4221029628 creator A5041158561 @default.
• W4221029628 date "2021-09-01" @default.
• W4221029628 modified "2023-10-11" @default.
• W4221029628 title "Recent insights into the relative timing of myosin's powerstroke and release of phosphate" @default.
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• W4221029628 cites W1980676208 @default.
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• W4221029628 doi "https://doi.org/10.1002/cm.21695" @default.
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