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- W4221030688 abstract "This chapter describes technical aspects of enumeration of reticulocytes and Heinz bodies. Evaluation of reticulocytes is a critical step in the evaluation of anemia. One major type of anemia is Heinz body anemia and that diagnosis requires detection and enumeration of the number and approximate mass of Heinz bodies in erythrocytes. Sample-induced errors (usually false increases) in reticulocyte counting include Howell–Jolly bodies, Heinz bodies, basophilic stippling, blood parasites, and large platelets with abundant RNA. Heinz bodies may be small, granular, and numerous, and may be mistaken for reticulocytes in blood smears with reticulocyte staining. Heinz bodies are formed from denatured, precipitated hemoglobin resulting from oxidative damage. Sulfhemoglobin and denatured hemoglobin are less soluble than normal hemoglobin, so they precipitate to form Heinz bodies that bind to the cell membrane. Oxidation damage to the membrane causes eccentrocyte formation." @default.
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- W4221030688 date "2022-03-04" @default.
- W4221030688 modified "2023-09-27" @default.
- W4221030688 title "Reticulocyte and Heinz Body Staining and Enumeration" @default.
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- W4221030688 doi "https://doi.org/10.1002/9781119500537.ch23" @default.
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