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• W4221031623 abstract "Abstract Purpose: Well-differentiated lung neuroendocrine tumors (Lu-NET) are classified as typical (TC) and atypical (AC) carcinoids, based on mitotic counts and necrosis. However, prognostic factors, other than tumor node metastasis (TNM) stage and the histopathological diagnosis, are still lacking. The current study is aimed to identify potential prognostic factors to better stratify lung NET, thus, improving patients’ treatment strategy and follow-up. Methods: A multicentric retrospective study, including 300 Lung NET, all surgically removed, from Italian and Spanish Institutions. Results: Median age 61 years (13–86), 37.7% were males, 25.0% were AC, 42.0% were located in the lung left parenchyma, 80.3% presented a TNM stage I-II. Mitotic count was ≥2 per 10 high-power field (HPF) in 24.7%, necrosis in 13.0%. Median overall survival (OS) was 46.1 months (0.6–323), median progression-free survival (PFS) was 36.0 months (0.3–323). Female sex correlated with a more indolent disease (T1; N0; lower Ki67; lower mitotic count and the absence of necrosis). Left-sided primary tumors were associated with higher mitotic count and necrosis. At Cox-multivariate regression model, age, left-sided tumors, nodal (N) positive status and the diagnosis of AC resulted independent negative prognostic factors for PFS and OS. Conclusions: This study highlights that laterality is an independent prognostic factors in Lu-NETs, with left tumors being less frequent but showing a worse prognosis than right ones. A wider spectrum of clinical and pathological prognostic factors, including TNM stage, age and laterality is suggested. These parameters could help clinicians to personalize the management of Lu-NET." @default.
• W4221031623 created "2022-04-03" @default.
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• W4221031623 date "2022-03-18" @default.
• W4221031623 modified "2023-10-02" @default.
• W4221031623 title "Prognostic significance of laterality in lung neuroendocrine tumors" @default.
• W4221031623 cites W1971858037 @default.
• W4221031623 cites W1984425190 @default.
• W4221031623 cites W1985213644 @default.
• W4221031623 cites W1991664660 @default.
• W4221031623 cites W2025095579 @default.
• W4221031623 cites W2038869171 @default.
• W4221031623 cites W2056069786 @default.
• W4221031623 cites W2073444968 @default.
• W4221031623 cites W2080301934 @default.
• W4221031623 cites W2095768013 @default.
• W4221031623 cites W2107058542 @default.
• W4221031623 cites W2108070570 @default.
• W4221031623 cites W2132085487 @default.
• W4221031623 cites W2143827882 @default.
• W4221031623 cites W2149214723 @default.
• W4221031623 cites W2156627275 @default.
• W4221031623 cites W2164118670 @default.
• W4221031623 cites W2164252602 @default.
• W4221031623 cites W2186341265 @default.
• W4221031623 cites W2416100501 @default.
• W4221031623 cites W2556183148 @default.
• W4221031623 cites W2586030734 @default.
• W4221031623 cites W2597872842 @default.
• W4221031623 cites W2607074905 @default.
• W4221031623 cites W2608160487 @default.
• W4221031623 cites W2611497676 @default.
• W4221031623 cites W2749130076 @default.
• W4221031623 cites W2753849780 @default.
• W4221031623 cites W2763121756 @default.
• W4221031623 cites W2775732618 @default.
• W4221031623 cites W2789033207 @default.
• W4221031623 cites W2791317291 @default.
• W4221031623 cites W2792490359 @default.
• W4221031623 cites W2803973904 @default.
• W4221031623 cites W2808588266 @default.
• W4221031623 cites W2884941995 @default.
• W4221031623 cites W2888018398 @default.
• W4221031623 cites W2893514262 @default.
• W4221031623 cites W2899959247 @default.
• W4221031623 cites W2900848193 @default.
• W4221031623 cites W2902067125 @default.
• W4221031623 cites W2913336223 @default.
• W4221031623 cites W2925251913 @default.
• W4221031623 cites W2946446150 @default.
• W4221031623 cites W2962872189 @default.
• W4221031623 cites W2967701358 @default.
• W4221031623 cites W2969244921 @default.
• W4221031623 cites W2969619142 @default.
• W4221031623 cites W2983614824 @default.
• W4221031623 cites W2997282512 @default.
• W4221031623 cites W3006969273 @default.
• W4221031623 cites W3015422734 @default.
• W4221031623 cites W3032888757 @default.
• W4221031623 cites W3038726810 @default.
• W4221031623 cites W3040714822 @default.
• W4221031623 cites W3047310121 @default.
• W4221031623 cites W3047924196 @default.
• W4221031623 cites W3084295316 @default.
• W4221031623 cites W3097246853 @default.
• W4221031623 cites W3106273722 @default.

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