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• W4221034089 abstract "Abstract Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients suffering from binge eating disorder (BED). Here, we used responsive deep brain stimulation (DBS) to record NAc electrophysiology during food cravings preceding LOC eating in two patients with BED and severe obesity (NCT03868670). Increased NAc low-frequency oscillations prominent during food cravings were used to guide DBS delivery. Over 6 months, we observed improved self-control of food intake and weight loss. These findings provide early support for restoring inhibitory control with electrophysiologically-guided NAc DBS. Further work is required to determine scalability of this approach. Trial Registration # NCT03868670." @default.
• W4221034089 created "2022-04-03" @default.
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• W4221034089 date "2022-03-15" @default.
• W4221034089 modified "2023-09-26" @default.
• W4221034089 title "Responsive nucleus accumbens deep brain stimulation restores eating control in severe obesity" @default.
• W4221034089 doi "https://doi.org/10.21203/rs.3.rs-1432380/v1" @default.
• W4221034089 hasPublicationYear "2022" @default.
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