Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221034112> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4221034112 abstract "Toll-like receptor (TLR)-4 plays a vital role in recognizing viral particles, activating the innate immune system, and producing pro-inflammatory cytokines.This cross-sectional study aimed to compare COVID-19 severity, progression, and fate according to TLR-4 (Asp299Gly) polymorphism in Egyptian patients.A total of 145 COVID-19 patients were included in this study. TLR-4 (Asp299Gly) genotyping was done using the PCR restriction fragment length polymorphism (PCR-RFLP) approach.The most commonly encountered TLR-4 genotype in relation to the amino acid at position 299 was the wild-type AA (73.1%); meanwhile, the homozygous mutant GG genotype (8.3%) was the least encountered. At hospital admission, 85.8% of the AA group had free (with no ground glass opacities) chest computed tomography (CT) examination, and 16.0% were asymptomatic. On the other hand, of the AG and GG groups, 81.5% and 83.3%, respectively showed bilateral ground-glass opacities in chest CT, as well as 25.9% and 75.0%, respectively were dyspneic. Values of the total leucocytic count, C-reactive protein (CRP), ferritin, and D dimer increased in the AA<AG<GG sequence. In contrast, hemoglobin values and the absolute lymphocyte counts decreased in the AA>AG>GG sequence. ICU admission (83.3%) and in-hospital death (33.3%) rates were significantly higher in the GG group.In COVID-19 patients, the TLR-4 mutant G allele may be associated with a more aggressive disease course and in-hospital death. New therapeutic alternatives could be aimed at this area." @default.
- W4221034112 created "2022-04-03" @default.
- W4221034112 creator A5003287914 @default.
- W4221034112 creator A5012848773 @default.
- W4221034112 creator A5013671913 @default.
- W4221034112 creator A5018902087 @default.
- W4221034112 creator A5027112436 @default.
- W4221034112 creator A5043589242 @default.
- W4221034112 date "2022-03-01" @default.
- W4221034112 modified "2023-10-01" @default.
- W4221034112 title "Comparison of COVID-19 characteristics in Egyptian patients according to their Toll-Like Receptor-4 (Asp299Gly) polymorphism" @default.
- W4221034112 cites W1483162601 @default.
- W4221034112 cites W1655860314 @default.
- W4221034112 cites W1995586746 @default.
- W4221034112 cites W2000056214 @default.
- W4221034112 cites W2038486513 @default.
- W4221034112 cites W2042815338 @default.
- W4221034112 cites W2067359484 @default.
- W4221034112 cites W2162074992 @default.
- W4221034112 cites W2591554718 @default.
- W4221034112 cites W2791153647 @default.
- W4221034112 cites W2891237012 @default.
- W4221034112 cites W2944584167 @default.
- W4221034112 cites W3008090866 @default.
- W4221034112 cites W3018507926 @default.
- W4221034112 cites W3024222526 @default.
- W4221034112 cites W3042257644 @default.
- W4221034112 cites W3043214385 @default.
- W4221034112 cites W3045837063 @default.
- W4221034112 cites W3047396241 @default.
- W4221034112 cites W3049691358 @default.
- W4221034112 cites W3084690339 @default.
- W4221034112 cites W3118936410 @default.
- W4221034112 cites W3122114103 @default.
- W4221034112 cites W3128725407 @default.
- W4221034112 cites W3133624849 @default.
- W4221034112 cites W3135360747 @default.
- W4221034112 cites W3164527614 @default.
- W4221034112 cites W3174522369 @default.
- W4221034112 cites W3216618563 @default.
- W4221034112 doi "https://doi.org/10.53854/liim-3001-11" @default.
- W4221034112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35350262" @default.
- W4221034112 hasPublicationYear "2022" @default.
- W4221034112 type Work @default.
- W4221034112 citedByCount "3" @default.
- W4221034112 countsByYear W42210341122022 @default.
- W4221034112 countsByYear W42210341122023 @default.
- W4221034112 crossrefType "journal-article" @default.
- W4221034112 hasAuthorship W4221034112A5003287914 @default.
- W4221034112 hasAuthorship W4221034112A5012848773 @default.
- W4221034112 hasAuthorship W4221034112A5013671913 @default.
- W4221034112 hasAuthorship W4221034112A5018902087 @default.
- W4221034112 hasAuthorship W4221034112A5027112436 @default.
- W4221034112 hasAuthorship W4221034112A5043589242 @default.
- W4221034112 hasBestOaLocation W42210341121 @default.
- W4221034112 hasConcept C104317684 @default.
- W4221034112 hasConcept C126322002 @default.
- W4221034112 hasConcept C135763542 @default.
- W4221034112 hasConcept C203014093 @default.
- W4221034112 hasConcept C2777910003 @default.
- W4221034112 hasConcept C31467283 @default.
- W4221034112 hasConcept C54355233 @default.
- W4221034112 hasConcept C71924100 @default.
- W4221034112 hasConcept C86803240 @default.
- W4221034112 hasConcept C90924648 @default.
- W4221034112 hasConceptScore W4221034112C104317684 @default.
- W4221034112 hasConceptScore W4221034112C126322002 @default.
- W4221034112 hasConceptScore W4221034112C135763542 @default.
- W4221034112 hasConceptScore W4221034112C203014093 @default.
- W4221034112 hasConceptScore W4221034112C2777910003 @default.
- W4221034112 hasConceptScore W4221034112C31467283 @default.
- W4221034112 hasConceptScore W4221034112C54355233 @default.
- W4221034112 hasConceptScore W4221034112C71924100 @default.
- W4221034112 hasConceptScore W4221034112C86803240 @default.
- W4221034112 hasConceptScore W4221034112C90924648 @default.
- W4221034112 hasIssue "1" @default.
- W4221034112 hasLocation W42210341121 @default.
- W4221034112 hasLocation W42210341122 @default.
- W4221034112 hasLocation W42210341123 @default.
- W4221034112 hasOpenAccess W4221034112 @default.
- W4221034112 hasPrimaryLocation W42210341121 @default.
- W4221034112 hasRelatedWork W1995188757 @default.
- W4221034112 hasRelatedWork W2016679923 @default.
- W4221034112 hasRelatedWork W2057721052 @default.
- W4221034112 hasRelatedWork W2101291023 @default.
- W4221034112 hasRelatedWork W2116001782 @default.
- W4221034112 hasRelatedWork W2182370226 @default.
- W4221034112 hasRelatedWork W2423950151 @default.
- W4221034112 hasRelatedWork W2763646354 @default.
- W4221034112 hasRelatedWork W3006519870 @default.
- W4221034112 hasRelatedWork W4229900919 @default.
- W4221034112 hasVolume "30" @default.
- W4221034112 isParatext "false" @default.
- W4221034112 isRetracted "false" @default.
- W4221034112 workType "article" @default.