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- W4221034233 abstract "Abstract It has shown that mouse cytomegalovirus (MCMV) infection induced low-expression of miR-1929-3p is closely related to hypertensive myocardial remodeling in our previous research. In this study, we further explored the molecular mechanism of myocardial remodeling induced by miR-1929-3p after MCMV infection on cellular level. We built MCMV infected mouse cardiac fibroblasts (MMCFs) as main cell model. First, MCMV infection caused low-expression of miR-1929-3p and higher mRNA and protein expression of its target gene endothelin receptor type A (ETAR) in mouse cardiac fibroblasts (MCFs), which showed an internal relation to myocardial fibrosis (MF) on high proliferation, phenotypic transformation (α-SMA) and collagen expression in MMCFs. Then, transfection of miR-1929-3p mimic down-regulated the high expression of ETAR and relieve these adverse effects in MMCFs. Inversely, these effects were exacerbated by miR-1929-3p inhibitor. Second, transfection of endothelin receptor type A over-expressed adenovirus (adETAR) reversed these positive effects of miR-1929-3p mimic about MF improvement. Third, it presented strong inflammatory response in MMCFs with more expression of NOD like receptors pyrin domain containing 3 (NLRP3) and secretion of interleukin-18 (IL-18). However, we found ETAR antagonist BQ123 and selected NLRP3 inflammasome inhibitor MCC950 effectively eliminated the inflammatory response induced by both MCMV infection and miR-1929-3p inhibitor. Moreover, the supernatant of MCFs was shown to be related to cardiomyocyte hypertrophy. Our research revealed that MCMV infection promotes MF by inducing down-regulation of miR-1929-3p and high expression of ETAR which activate NLRP3 inflammasome in MCFs." @default.
- W4221034233 created "2022-04-03" @default.
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- W4221034233 date "2022-03-16" @default.
- W4221034233 modified "2023-09-24" @default.
- W4221034233 title "Low-expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin A receptor/NLRP3 inflammasome pathway" @default.
- W4221034233 doi "https://doi.org/10.21203/rs.3.rs-1447483/v1" @default.
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