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- W4221034384 abstract "Neurons provide a rich setting for studying post-transcriptional control. Here, we investigate the landscape of translational control in neurons and search for mRNA features that explain differences in translational efficiency (TE), considering the interplay between TE, mRNA poly(A)-tail lengths, microRNAs, and neuronal activation. In neurons and brain tissues, TE correlates with tail length, and a few dozen mRNAs appear to undergo cytoplasmic polyadenylation upon light or chemical stimulation. However, the correlation between TE and tail length is modest, explaining <5% of TE variance, and even this modest relationship diminishes when accounting for other mRNA features. Thus, tail length appears to affect TE only minimally. Accordingly, miRNAs, which accelerate deadenylation of their mRNA targets, primarily influence target mRNA levels, with no detectable effect on either steady-state tail lengths or TE. Larger correlates with TE include codon composition and predicted mRNA folding energy. When combined in a model, the identified correlates explain 38%-45% of TE variance. These results provide a framework for considering the relative impact of factors that contribute to translational control in neurons. They indicate that when examined in bulk, translational control in neurons largely resembles that of other types of post-embryonic cells. Thus, detection of more specialized control might require analyses that can distinguish translation occurring in neuronal processes from that occurring in cell bodies." @default.
- W4221034384 created "2022-04-03" @default.
- W4221034384 creator A5045434495 @default.
- W4221034384 creator A5060602972 @default.
- W4221034384 creator A5087589263 @default.
- W4221034384 date "2022-03-10" @default.
- W4221034384 modified "2023-09-28" @default.
- W4221034384 title "The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation" @default.
- W4221034384 cites W1196894603 @default.
- W4221034384 cites W1489324264 @default.
- W4221034384 cites W1744683414 @default.
- W4221034384 cites W1966901093 @default.
- W4221034384 cites W1970215478 @default.
- W4221034384 cites W1974394989 @default.
- W4221034384 cites W1976515682 @default.
- W4221034384 cites W1982807202 @default.
- W4221034384 cites W1983859619 @default.
- W4221034384 cites W1984678540 @default.
- W4221034384 cites W1984940197 @default.
- W4221034384 cites W1988432188 @default.
- W4221034384 cites W1997809760 @default.
- W4221034384 cites W1998819524 @default.
- W4221034384 cites W2000189769 @default.
- W4221034384 cites W2009401980 @default.
- W4221034384 cites W2011503994 @default.
- W4221034384 cites W2016243020 @default.
- W4221034384 cites W2027767007 @default.
- W4221034384 cites W2029905838 @default.
- W4221034384 cites W2030320309 @default.
- W4221034384 cites W2035082265 @default.
- W4221034384 cites W2039912628 @default.
- W4221034384 cites W2044273755 @default.
- W4221034384 cites W2054275187 @default.
- W4221034384 cites W2069527370 @default.
- W4221034384 cites W2071950386 @default.
- W4221034384 cites W2072770570 @default.
- W4221034384 cites W2076398196 @default.
- W4221034384 cites W2079517684 @default.
- W4221034384 cites W2079540311 @default.
- W4221034384 cites W2086561953 @default.
- W4221034384 cites W2095370567 @default.
- W4221034384 cites W2099159538 @default.
- W4221034384 cites W2100377381 @default.
- W4221034384 cites W2108994898 @default.
- W4221034384 cites W2109505983 @default.
- W4221034384 cites W2109851824 @default.
- W4221034384 cites W2116486533 @default.
- W4221034384 cites W2120053143 @default.
- W4221034384 cites W2120595470 @default.
- W4221034384 cites W2126096918 @default.
- W4221034384 cites W2128551987 @default.
- W4221034384 cites W2133968430 @default.
- W4221034384 cites W2134629862 @default.
- W4221034384 cites W2137586531 @default.
- W4221034384 cites W2142635246 @default.
- W4221034384 cites W2142979031 @default.
- W4221034384 cites W2152146470 @default.
- W4221034384 cites W2152239989 @default.
- W4221034384 cites W2158323020 @default.
- W4221034384 cites W2162674813 @default.
- W4221034384 cites W2164440878 @default.
- W4221034384 cites W2170513170 @default.
- W4221034384 cites W2170669858 @default.
- W4221034384 cites W2175902342 @default.
- W4221034384 cites W2180986577 @default.
- W4221034384 cites W2261298189 @default.
- W4221034384 cites W2293311540 @default.
- W4221034384 cites W2470921489 @default.
- W4221034384 cites W2487617124 @default.
- W4221034384 cites W2493043445 @default.
- W4221034384 cites W2495238549 @default.
- W4221034384 cites W2508862690 @default.
- W4221034384 cites W2565070561 @default.
- W4221034384 cites W2633823184 @default.
- W4221034384 cites W2738135994 @default.
- W4221034384 cites W2740852495 @default.
- W4221034384 cites W2755967204 @default.
- W4221034384 cites W2761423809 @default.
- W4221034384 cites W2766187665 @default.
- W4221034384 cites W2773035279 @default.
- W4221034384 cites W2793056129 @default.
- W4221034384 cites W2802208666 @default.
- W4221034384 cites W2886042183 @default.
- W4221034384 cites W2887478137 @default.
- W4221034384 cites W2898814165 @default.
- W4221034384 cites W2949452190 @default.
- W4221034384 cites W2951344785 @default.
- W4221034384 cites W2951588146 @default.
- W4221034384 cites W2953016965 @default.
- W4221034384 cites W2953683903 @default.
- W4221034384 cites W2956786125 @default.
- W4221034384 cites W2962101943 @default.
- W4221034384 cites W2966944951 @default.
- W4221034384 cites W2980216658 @default.
- W4221034384 cites W2996899481 @default.
- W4221034384 cites W2996988556 @default.
- W4221034384 cites W3004286746 @default.
- W4221034384 cites W3004317045 @default.