Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221035931> ?p ?o ?g. }
- W4221035931 endingPage "106173" @default.
- W4221035931 startingPage "106173" @default.
- W4221035931 abstract "Emerging evidence indicates that HSP70 represents a key mechanism in the pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications, including micro- and macro-vascular alterations, as well as impaired hemostasis. Hyperglycemia, a hallmark of both types of diabetes, increases the circulating levels of HSP70 (eHSP70), but there is still divergence about whether diabetes up- or down-regulates the intracellular fraction of this protein (iHSP70). Here, we consider that iHSP70 levels reduce in diabetic arterial structures and that the vascular system is in direct contact with all other systems in the body suggesting that a systemic response might also be happening for iHSP70, which is characterized by decreased levels of HSP70 in the vasculature. Furthermore, although many pathways have been proposed to explain HSP70's functions in diabetes, and organs/tissues/cells-specific variations occur, the membrane-bound receptor of the innate immune system, Toll-like receptor 4, and its downstream signal transduction pathways appear to be a constant, not only when we explore the actions of eHSP70, but also when we assess the contributions of iHSP70. In this review, we focus on discussing the multiple roles of HSP70 across organs/tissues/cells affected by hyperglycemia to further explore the possibility of targeting this protein with pharmacological and non-pharmacological approaches in the context of diabetes." @default.
- W4221035931 created "2022-04-03" @default.
- W4221035931 creator A5028789700 @default.
- W4221035931 creator A5046059123 @default.
- W4221035931 creator A5051292088 @default.
- W4221035931 creator A5060451577 @default.
- W4221035931 date "2022-04-01" @default.
- W4221035931 modified "2023-10-18" @default.
- W4221035931 title "New insights into the role and therapeutic potential of HSP70 in diabetes" @default.
- W4221035931 cites W1525864426 @default.
- W4221035931 cites W1657168255 @default.
- W4221035931 cites W1845977673 @default.
- W4221035931 cites W1902733438 @default.
- W4221035931 cites W1968134516 @default.
- W4221035931 cites W1971529415 @default.
- W4221035931 cites W1972744591 @default.
- W4221035931 cites W1975857716 @default.
- W4221035931 cites W1978634585 @default.
- W4221035931 cites W1979681605 @default.
- W4221035931 cites W1980353960 @default.
- W4221035931 cites W1980505864 @default.
- W4221035931 cites W1983194893 @default.
- W4221035931 cites W1983321019 @default.
- W4221035931 cites W1983840740 @default.
- W4221035931 cites W1986597159 @default.
- W4221035931 cites W1989882906 @default.
- W4221035931 cites W1990922120 @default.
- W4221035931 cites W1993193694 @default.
- W4221035931 cites W1995289028 @default.
- W4221035931 cites W1995717532 @default.
- W4221035931 cites W1998377463 @default.
- W4221035931 cites W1998666012 @default.
- W4221035931 cites W2001569984 @default.
- W4221035931 cites W2003667600 @default.
- W4221035931 cites W2008614812 @default.
- W4221035931 cites W2012507058 @default.
- W4221035931 cites W2012871231 @default.
- W4221035931 cites W2014629598 @default.
- W4221035931 cites W2016285157 @default.
- W4221035931 cites W2016467663 @default.
- W4221035931 cites W2020031150 @default.
- W4221035931 cites W2025793289 @default.
- W4221035931 cites W2030907322 @default.
- W4221035931 cites W2032310106 @default.
- W4221035931 cites W2032687008 @default.
- W4221035931 cites W2033049359 @default.
- W4221035931 cites W2036377986 @default.
- W4221035931 cites W2036506653 @default.
- W4221035931 cites W2040377780 @default.
- W4221035931 cites W2040560600 @default.
- W4221035931 cites W2042211608 @default.
- W4221035931 cites W2042621583 @default.
- W4221035931 cites W2044121680 @default.
- W4221035931 cites W2051547820 @default.
- W4221035931 cites W2052055418 @default.
- W4221035931 cites W2052544769 @default.
- W4221035931 cites W2056309362 @default.
- W4221035931 cites W2056911532 @default.
- W4221035931 cites W2058262070 @default.
- W4221035931 cites W2058442554 @default.
- W4221035931 cites W2058676815 @default.
- W4221035931 cites W2059843925 @default.
- W4221035931 cites W2061738083 @default.
- W4221035931 cites W2062573090 @default.
- W4221035931 cites W2062618220 @default.
- W4221035931 cites W2063078660 @default.
- W4221035931 cites W2063664389 @default.
- W4221035931 cites W2063803233 @default.
- W4221035931 cites W2064479644 @default.
- W4221035931 cites W2065501573 @default.
- W4221035931 cites W2067747345 @default.
- W4221035931 cites W2073645396 @default.
- W4221035931 cites W2073931306 @default.
- W4221035931 cites W2076531747 @default.
- W4221035931 cites W2078711922 @default.
- W4221035931 cites W2078741614 @default.
- W4221035931 cites W2080143014 @default.
- W4221035931 cites W2082066647 @default.
- W4221035931 cites W2083501599 @default.
- W4221035931 cites W2086667809 @default.
- W4221035931 cites W2087477704 @default.
- W4221035931 cites W2089400513 @default.
- W4221035931 cites W2089865544 @default.
- W4221035931 cites W2089894237 @default.
- W4221035931 cites W2090343539 @default.
- W4221035931 cites W2091117109 @default.
- W4221035931 cites W2094605832 @default.
- W4221035931 cites W2095231417 @default.
- W4221035931 cites W2096027130 @default.
- W4221035931 cites W2096531477 @default.
- W4221035931 cites W2100321469 @default.
- W4221035931 cites W2102667122 @default.
- W4221035931 cites W2102974725 @default.
- W4221035931 cites W2104969665 @default.
- W4221035931 cites W2104969697 @default.
- W4221035931 cites W2107449846 @default.
- W4221035931 cites W2108112200 @default.
- W4221035931 cites W2109936231 @default.