Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221036257> ?p ?o ?g. }
- W4221036257 endingPage "819" @default.
- W4221036257 startingPage "819" @default.
- W4221036257 abstract "The etiology of spontaneous cranial cruciate ligament rupture in dogs is unknown despite being one of the most impacting orthopedic diseases in dogs. Numerous studies have contributed to the understanding of a multifactorial pathogenesis, this, however, without identifying a pivotal link to explain progressive collagen degeneration and osteoarthritic changes. In human medicine, recent reports have identified relaxin as a triggering factor in ligament ruptures in knee and metacarpal joints. We thus hypothesized that relaxin might also play a role in canine cruciate ligament rupture. Relaxin's primarily known property is connective tissue remodeling through collagenolysis. We therefore investigated relaxin and its cognate receptors LGR7/LGR8 in 18 dogs with cranial cruciate ligament disease (CCLD) and compared them to a group of dogs with normal stifle joints. Applying immunohistochemistry (IHC), double immunofluorescence (dIF), and western blot analysis (WB), we found strong and significantly increased expression of both relaxin and its receptors in ruptured cruciate ligaments, and in synovial membranes. Pattern of immuno-staining on dIF strongly suggests relaxin binding to primed receptors and activation of signaling properties, which in turn may have affected collagen matrix metabolism. Thus, in canine cranial cruciate ligament disease, relaxin/receptor signaling may be a primary trigger for collagen fiber degradation and collagen lysis, eventually followed by ligament rupture." @default.
- W4221036257 created "2022-04-03" @default.
- W4221036257 creator A5013867773 @default.
- W4221036257 creator A5048096276 @default.
- W4221036257 creator A5049848248 @default.
- W4221036257 creator A5061766392 @default.
- W4221036257 creator A5066145299 @default.
- W4221036257 creator A5068262515 @default.
- W4221036257 creator A5072333272 @default.
- W4221036257 creator A5086765607 @default.
- W4221036257 date "2022-03-23" @default.
- W4221036257 modified "2023-09-26" @default.
- W4221036257 title "Immunoexpression of Relaxin and Its Receptors in Stifle Joints of Dogs with Cranial Cruciate Ligament Disease" @default.
- W4221036257 cites W100331167 @default.
- W4221036257 cites W114947228 @default.
- W4221036257 cites W130407398 @default.
- W4221036257 cites W137709055 @default.
- W4221036257 cites W151361557 @default.
- W4221036257 cites W1534092934 @default.
- W4221036257 cites W1605091374 @default.
- W4221036257 cites W1643553122 @default.
- W4221036257 cites W175215739 @default.
- W4221036257 cites W1964509523 @default.
- W4221036257 cites W1965077166 @default.
- W4221036257 cites W1967421454 @default.
- W4221036257 cites W1976045588 @default.
- W4221036257 cites W1979487118 @default.
- W4221036257 cites W1979808924 @default.
- W4221036257 cites W1982789702 @default.
- W4221036257 cites W1985283806 @default.
- W4221036257 cites W1995168474 @default.
- W4221036257 cites W2003985770 @default.
- W4221036257 cites W2006472951 @default.
- W4221036257 cites W2014338557 @default.
- W4221036257 cites W2014857562 @default.
- W4221036257 cites W2020410508 @default.
- W4221036257 cites W2023319502 @default.
- W4221036257 cites W2034624992 @default.
- W4221036257 cites W2034862008 @default.
- W4221036257 cites W2036931107 @default.
- W4221036257 cites W2053025226 @default.
- W4221036257 cites W2057839958 @default.
- W4221036257 cites W2058211473 @default.
- W4221036257 cites W2062850369 @default.
- W4221036257 cites W2071340050 @default.
- W4221036257 cites W2077959759 @default.
- W4221036257 cites W2079535295 @default.
- W4221036257 cites W2087336054 @default.
- W4221036257 cites W2089456507 @default.
- W4221036257 cites W2092099551 @default.
- W4221036257 cites W2094300803 @default.
- W4221036257 cites W2110544750 @default.
- W4221036257 cites W2112825838 @default.
- W4221036257 cites W2115062328 @default.
- W4221036257 cites W2117999516 @default.
- W4221036257 cites W2132342393 @default.
- W4221036257 cites W2139097320 @default.
- W4221036257 cites W2152593951 @default.
- W4221036257 cites W2152842279 @default.
- W4221036257 cites W2163145607 @default.
- W4221036257 cites W2163757624 @default.
- W4221036257 cites W2166866785 @default.
- W4221036257 cites W2169781337 @default.
- W4221036257 cites W2179600275 @default.
- W4221036257 cites W2188398145 @default.
- W4221036257 cites W2275299696 @default.
- W4221036257 cites W2319069622 @default.
- W4221036257 cites W2343967025 @default.
- W4221036257 cites W23566666 @default.
- W4221036257 cites W2404565990 @default.
- W4221036257 cites W2411211573 @default.
- W4221036257 cites W2467812623 @default.
- W4221036257 cites W2516453631 @default.
- W4221036257 cites W25866855 @default.
- W4221036257 cites W2901004328 @default.
- W4221036257 cites W2914594285 @default.
- W4221036257 cites W2994220074 @default.
- W4221036257 cites W3099751764 @default.
- W4221036257 cites W3137438249 @default.
- W4221036257 cites W3189345255 @default.
- W4221036257 cites W37061215 @default.
- W4221036257 cites W4210717944 @default.
- W4221036257 cites W4300328616 @default.
- W4221036257 cites W2607639783 @default.
- W4221036257 doi "https://doi.org/10.3390/ani12070819" @default.
- W4221036257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35405809" @default.
- W4221036257 hasPublicationYear "2022" @default.
- W4221036257 type Work @default.
- W4221036257 citedByCount "2" @default.
- W4221036257 countsByYear W42210362572023 @default.
- W4221036257 crossrefType "journal-article" @default.
- W4221036257 hasAuthorship W4221036257A5013867773 @default.
- W4221036257 hasAuthorship W4221036257A5048096276 @default.
- W4221036257 hasAuthorship W4221036257A5049848248 @default.
- W4221036257 hasAuthorship W4221036257A5061766392 @default.
- W4221036257 hasAuthorship W4221036257A5066145299 @default.
- W4221036257 hasAuthorship W4221036257A5068262515 @default.
- W4221036257 hasAuthorship W4221036257A5072333272 @default.