Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221038405> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4221038405 abstract "With increasing availability of disease-modifying therapies (DMTs), treatment decisions in relapsing-remitting multiple sclerosis (RRMS) have become complex. Data-driven algorithms based on real-world outcomes may help clinicians optimize control of disease activity in routine praxis.We previously introduced the PHREND® (Predictive-Healthcare-with-Real-World-Evidence-for-Neurological-Disorders) algorithm based on data from 2018 and now follow up on its robustness and utility to predict freedom of relapse and 3-months confirmed disability progression (3mCDP) during 1.5 years of clinical practice.The impact of quarterly data updates on model robustness was investigated based on the model's C-index and credible intervals for coefficients. Model predictions were compared with results from randomized clinical trials (RCTs). Clinical relevance was evaluated by comparing outcomes of patients for whom model recommendations were followed with those choosing other treatments.Model robustness improved with the addition of 1.5 years of data. Comparison with RCTs revealed differences <10% of the model-based predictions in almost all trials. Treatment with the highest-ranked (by PHREND®) or the first-or-second-highest ranked DMT led to significantly fewer relapses (p < 0.001 and p < 0.001, respectively) and 3mCDP events (p = 0.007 and p = 0.035, respectively) compared to non-recommended DMTs.These results further support usefulness of PHREND® in a shared treatment-decision process between physicians and patients." @default.
- W4221038405 created "2022-04-03" @default.
- W4221038405 creator A5010506814 @default.
- W4221038405 creator A5021693174 @default.
- W4221038405 creator A5026559312 @default.
- W4221038405 creator A5036694649 @default.
- W4221038405 creator A5078317661 @default.
- W4221038405 date "2022-03-11" @default.
- W4221038405 modified "2023-10-18" @default.
- W4221038405 title "PHREND®—A Real-World Data-Driven Tool Supporting Clinical Decisions to Optimize Treatment in Relapsing-Remitting Multiple Sclerosis" @default.
- W4221038405 cites W1563651942 @default.
- W4221038405 cites W1967838438 @default.
- W4221038405 cites W2034417379 @default.
- W4221038405 cites W2043591841 @default.
- W4221038405 cites W2093009907 @default.
- W4221038405 cites W2103758700 @default.
- W4221038405 cites W2139204856 @default.
- W4221038405 cites W2151340435 @default.
- W4221038405 cites W2166983650 @default.
- W4221038405 cites W2561881161 @default.
- W4221038405 cites W2794109224 @default.
- W4221038405 cites W2896031745 @default.
- W4221038405 cites W2957267947 @default.
- W4221038405 cites W3006577702 @default.
- W4221038405 cites W3009257014 @default.
- W4221038405 cites W3089077454 @default.
- W4221038405 cites W3133562316 @default.
- W4221038405 cites W3138241738 @default.
- W4221038405 cites W3148526428 @default.
- W4221038405 cites W3155971544 @default.
- W4221038405 cites W3165746929 @default.
- W4221038405 doi "https://doi.org/10.3389/fdgth.2022.856829" @default.
- W4221038405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35360367" @default.
- W4221038405 hasPublicationYear "2022" @default.
- W4221038405 type Work @default.
- W4221038405 citedByCount "0" @default.
- W4221038405 crossrefType "journal-article" @default.
- W4221038405 hasAuthorship W4221038405A5010506814 @default.
- W4221038405 hasAuthorship W4221038405A5021693174 @default.
- W4221038405 hasAuthorship W4221038405A5026559312 @default.
- W4221038405 hasAuthorship W4221038405A5036694649 @default.
- W4221038405 hasAuthorship W4221038405A5078317661 @default.
- W4221038405 hasBestOaLocation W42210384051 @default.
- W4221038405 hasConcept C104317684 @default.
- W4221038405 hasConcept C118552586 @default.
- W4221038405 hasConcept C126322002 @default.
- W4221038405 hasConcept C168563851 @default.
- W4221038405 hasConcept C185592680 @default.
- W4221038405 hasConcept C2522767166 @default.
- W4221038405 hasConcept C2779134260 @default.
- W4221038405 hasConcept C2780640218 @default.
- W4221038405 hasConcept C3020493868 @default.
- W4221038405 hasConcept C3020694758 @default.
- W4221038405 hasConcept C41008148 @default.
- W4221038405 hasConcept C535046627 @default.
- W4221038405 hasConcept C55493867 @default.
- W4221038405 hasConcept C63479239 @default.
- W4221038405 hasConcept C71924100 @default.
- W4221038405 hasConceptScore W4221038405C104317684 @default.
- W4221038405 hasConceptScore W4221038405C118552586 @default.
- W4221038405 hasConceptScore W4221038405C126322002 @default.
- W4221038405 hasConceptScore W4221038405C168563851 @default.
- W4221038405 hasConceptScore W4221038405C185592680 @default.
- W4221038405 hasConceptScore W4221038405C2522767166 @default.
- W4221038405 hasConceptScore W4221038405C2779134260 @default.
- W4221038405 hasConceptScore W4221038405C2780640218 @default.
- W4221038405 hasConceptScore W4221038405C3020493868 @default.
- W4221038405 hasConceptScore W4221038405C3020694758 @default.
- W4221038405 hasConceptScore W4221038405C41008148 @default.
- W4221038405 hasConceptScore W4221038405C535046627 @default.
- W4221038405 hasConceptScore W4221038405C55493867 @default.
- W4221038405 hasConceptScore W4221038405C63479239 @default.
- W4221038405 hasConceptScore W4221038405C71924100 @default.
- W4221038405 hasLocation W42210384051 @default.
- W4221038405 hasLocation W42210384052 @default.
- W4221038405 hasLocation W42210384053 @default.
- W4221038405 hasLocation W42210384054 @default.
- W4221038405 hasOpenAccess W4221038405 @default.
- W4221038405 hasPrimaryLocation W42210384051 @default.
- W4221038405 hasRelatedWork W1950521060 @default.
- W4221038405 hasRelatedWork W2004839802 @default.
- W4221038405 hasRelatedWork W2159343111 @default.
- W4221038405 hasRelatedWork W2727984870 @default.
- W4221038405 hasRelatedWork W2783858965 @default.
- W4221038405 hasRelatedWork W4254344425 @default.
- W4221038405 hasRelatedWork W4292707405 @default.
- W4221038405 hasRelatedWork W4311483557 @default.
- W4221038405 hasRelatedWork W2291724758 @default.
- W4221038405 hasRelatedWork W3126781973 @default.
- W4221038405 hasVolume "4" @default.
- W4221038405 isParatext "false" @default.
- W4221038405 isRetracted "false" @default.
- W4221038405 workType "article" @default.