Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221041172> ?p ?o ?g. }
- W4221041172 abstract "Summary paragraph Selective proton transport through proteins is essential for forming and utilizing proton gradients in cells. Protons are conducted along hydrogen-bonded “wires” of water molecules and polar sidechains, which, somewhat surprisingly, are often interrupted by dry apolar stretches in the conduction pathways inferred from static protein structures. We hypothesize that protons are conducted through such dry spots by forming transient water wires, often highly correlated with the presence of the excess proton itself in the water wire. To test this hypothesis, we used molecular dynamics simulations to design transmembrane channels with stable water pockets interspersed by apolar segments capable of forming flickering water wires. The minimalist designed channels conduct protons at rates similar to viral proton channels, and they are at least 10 6 -fold more selective for H + over Na + . These studies inform mechanisms of biological proton conduction and principles for engineering proton-conductive materials." @default.
- W4221041172 created "2022-04-03" @default.
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- W4221041172 date "2022-03-28" @default.
- W4221041172 modified "2023-09-25" @default.
- W4221041172 title "Transient Water Wires Mediate Selective Proton Transport in Designed Channel Proteins" @default.
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- W4221041172 doi "https://doi.org/10.1101/2022.03.28.485852" @default.
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