Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221049848> ?p ?o ?g. }
- W4221049848 endingPage "1176" @default.
- W4221049848 startingPage "1168" @default.
- W4221049848 abstract "SARS-CoV-2, the virus causing the COVID-19 pandemic, changes frequently through the appearance of mutations constantly leading to new variants. However, only few variants evolve as dominating and will be considered as Variants of Concern (VOCs) by the world health organization (WHO). At the end of 2020 the alpha (B.1.1.7) variant appeared in the United Kingdom and dominated the pandemic situation until mid of 2021 when it was substituted by the delta variant (B.1.617.2) that first appeared in India as predominant. At the end of 2021, SARS-CoV-2 omicron (B.1.1.529) evolved as the dominating variant. Here, we use in silico modeling and molecular dynamics (MD) simulations of the receptor-binding domain of the viral spike protein and the host cell surface receptor ACE2 to analyze and compare the interaction pattern between the wild type, delta and omicron variants. We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2." @default.
- W4221049848 created "2022-04-03" @default.
- W4221049848 creator A5019258439 @default.
- W4221049848 creator A5061611026 @default.
- W4221049848 creator A5073228339 @default.
- W4221049848 creator A5073944069 @default.
- W4221049848 creator A5076607475 @default.
- W4221049848 date "2022-01-01" @default.
- W4221049848 modified "2023-10-09" @default.
- W4221049848 title "Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants" @default.
- W4221049848 cites W1966238900 @default.
- W4221049848 cites W1968984443 @default.
- W4221049848 cites W1969189143 @default.
- W4221049848 cites W1976499671 @default.
- W4221049848 cites W1992344082 @default.
- W4221049848 cites W2004822259 @default.
- W4221049848 cites W2015642465 @default.
- W4221049848 cites W2035266068 @default.
- W4221049848 cites W2106140689 @default.
- W4221049848 cites W2114239896 @default.
- W4221049848 cites W2132629607 @default.
- W4221049848 cites W2313116527 @default.
- W4221049848 cites W2332712348 @default.
- W4221049848 cites W2404280981 @default.
- W4221049848 cites W2731784911 @default.
- W4221049848 cites W3004280078 @default.
- W4221049848 cites W3009912996 @default.
- W4221049848 cites W3033962914 @default.
- W4221049848 cites W3034202401 @default.
- W4221049848 cites W3048714202 @default.
- W4221049848 cites W3085153423 @default.
- W4221049848 cites W3086712138 @default.
- W4221049848 cites W3092403777 @default.
- W4221049848 cites W3093819516 @default.
- W4221049848 cites W3104727101 @default.
- W4221049848 cites W3129414840 @default.
- W4221049848 cites W3132472812 @default.
- W4221049848 cites W3137152384 @default.
- W4221049848 cites W3159257193 @default.
- W4221049848 cites W3160004557 @default.
- W4221049848 cites W3165205080 @default.
- W4221049848 cites W3172858351 @default.
- W4221049848 cites W3194649867 @default.
- W4221049848 cites W3199650593 @default.
- W4221049848 cites W3203433659 @default.
- W4221049848 cites W3208583661 @default.
- W4221049848 cites W3211890274 @default.
- W4221049848 cites W4200047841 @default.
- W4221049848 cites W4200469371 @default.
- W4221049848 doi "https://doi.org/10.1016/j.csbj.2022.02.015" @default.
- W4221049848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35251533" @default.
- W4221049848 hasPublicationYear "2022" @default.
- W4221049848 type Work @default.
- W4221049848 citedByCount "25" @default.
- W4221049848 countsByYear W42210498482022 @default.
- W4221049848 countsByYear W42210498482023 @default.
- W4221049848 crossrefType "journal-article" @default.
- W4221049848 hasAuthorship W4221049848A5019258439 @default.
- W4221049848 hasAuthorship W4221049848A5061611026 @default.
- W4221049848 hasAuthorship W4221049848A5073228339 @default.
- W4221049848 hasAuthorship W4221049848A5073944069 @default.
- W4221049848 hasAuthorship W4221049848A5076607475 @default.
- W4221049848 hasBestOaLocation W42210498481 @default.
- W4221049848 hasConcept C104317684 @default.
- W4221049848 hasConcept C142724271 @default.
- W4221049848 hasConcept C147597530 @default.
- W4221049848 hasConcept C159047783 @default.
- W4221049848 hasConcept C185592680 @default.
- W4221049848 hasConcept C2775905019 @default.
- W4221049848 hasConcept C2779134260 @default.
- W4221049848 hasConcept C2909509916 @default.
- W4221049848 hasConcept C3007834351 @default.
- W4221049848 hasConcept C3008058167 @default.
- W4221049848 hasConcept C524204448 @default.
- W4221049848 hasConcept C54355233 @default.
- W4221049848 hasConcept C59593255 @default.
- W4221049848 hasConcept C70721500 @default.
- W4221049848 hasConcept C71924100 @default.
- W4221049848 hasConcept C86803240 @default.
- W4221049848 hasConceptScore W4221049848C104317684 @default.
- W4221049848 hasConceptScore W4221049848C142724271 @default.
- W4221049848 hasConceptScore W4221049848C147597530 @default.
- W4221049848 hasConceptScore W4221049848C159047783 @default.
- W4221049848 hasConceptScore W4221049848C185592680 @default.
- W4221049848 hasConceptScore W4221049848C2775905019 @default.
- W4221049848 hasConceptScore W4221049848C2779134260 @default.
- W4221049848 hasConceptScore W4221049848C2909509916 @default.
- W4221049848 hasConceptScore W4221049848C3007834351 @default.
- W4221049848 hasConceptScore W4221049848C3008058167 @default.
- W4221049848 hasConceptScore W4221049848C524204448 @default.
- W4221049848 hasConceptScore W4221049848C54355233 @default.
- W4221049848 hasConceptScore W4221049848C59593255 @default.
- W4221049848 hasConceptScore W4221049848C70721500 @default.
- W4221049848 hasConceptScore W4221049848C71924100 @default.
- W4221049848 hasConceptScore W4221049848C86803240 @default.
- W4221049848 hasFunder F4320324796 @default.
- W4221049848 hasFunder F4320325724 @default.
- W4221049848 hasFunder F4320330129 @default.