Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221051330> ?p ?o ?g. }
- W4221051330 endingPage "112837" @default.
- W4221051330 startingPage "112837" @default.
- W4221051330 abstract "Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin's participation in the pathophysiology of withdrawal symptoms via modulation of gut microbiota.In order to define the functional impacts of gut microbiota and metformin to the behavioural deficits during METH withdrawal, we utilized a combination of fecal microbiota transplantation (FMT), high-throughput sequencing, and untargeted metabolomics technologies.First, METH addicts exhibited higher α diversity and distinct microbial structures compared to healthy controls. In particular, the relative abundance of Rikenellaceae was positively correlated with the severity of anxiety and depression. Second, both human-to-mouse and mouse-to-mouse FMTs confirmed that METH-altered-microbiota transplantation is sufficient to promote anxiety and depression-like behaviours in recipient germ-free mice, and these behavioural disturbances could be ameliorated by metformin. In-depth analysis revealed that METH significantly altered the bacterial composition and structure as well as relative abundance of several bacterial taxa and metabolites, including Rikenellaceae and inosine, respectively, whereas add-on metformin could remodel these alterations. Finally, the inosine complementation successfully restored METH-induced anxiety and depression-like behaviours in mice.This study demonstrates that METH withdrawal-induced anxiety and depression-like behaviours are reversible and transmissible via gut microbiota in a mouse model. The therapeutic effects of metformin on psychiatric manifestations are associated with microbiota-derived metabolites, highlighting the role of the gut microbiota in substance use disorders and the pathophysiology of withdrawal symptoms." @default.
- W4221051330 created "2022-04-03" @default.
- W4221051330 creator A5008989251 @default.
- W4221051330 creator A5012613639 @default.
- W4221051330 creator A5013070016 @default.
- W4221051330 creator A5016265600 @default.
- W4221051330 creator A5017762928 @default.
- W4221051330 creator A5022540352 @default.
- W4221051330 creator A5034177782 @default.
- W4221051330 creator A5034414842 @default.
- W4221051330 creator A5038417134 @default.
- W4221051330 creator A5045073296 @default.
- W4221051330 creator A5047452735 @default.
- W4221051330 creator A5047456141 @default.
- W4221051330 creator A5049523085 @default.
- W4221051330 creator A5061742939 @default.
- W4221051330 creator A5064559431 @default.
- W4221051330 creator A5065007219 @default.
- W4221051330 creator A5067153841 @default.
- W4221051330 creator A5068073726 @default.
- W4221051330 creator A5070233849 @default.
- W4221051330 creator A5074519028 @default.
- W4221051330 creator A5074934439 @default.
- W4221051330 creator A5086505100 @default.
- W4221051330 creator A5089169007 @default.
- W4221051330 creator A5091425820 @default.
- W4221051330 date "2022-05-01" @default.
- W4221051330 modified "2023-10-08" @default.
- W4221051330 title "Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice" @default.
- W4221051330 cites W1552025788 @default.
- W4221051330 cites W1943082353 @default.
- W4221051330 cites W2009939083 @default.
- W4221051330 cites W2021534324 @default.
- W4221051330 cites W2029204081 @default.
- W4221051330 cites W2036878287 @default.
- W4221051330 cites W2039845572 @default.
- W4221051330 cites W2067945221 @default.
- W4221051330 cites W2128367294 @default.
- W4221051330 cites W2134907909 @default.
- W4221051330 cites W2157383890 @default.
- W4221051330 cites W2161516646 @default.
- W4221051330 cites W2233569619 @default.
- W4221051330 cites W2292048640 @default.
- W4221051330 cites W2337492846 @default.
- W4221051330 cites W2367851449 @default.
- W4221051330 cites W2554850339 @default.
- W4221051330 cites W2566314801 @default.
- W4221051330 cites W2589674438 @default.
- W4221051330 cites W2615129326 @default.
- W4221051330 cites W2617940752 @default.
- W4221051330 cites W2624366687 @default.
- W4221051330 cites W2737230954 @default.
- W4221051330 cites W2765488260 @default.
- W4221051330 cites W2790863554 @default.
- W4221051330 cites W2795546890 @default.
- W4221051330 cites W2808778563 @default.
- W4221051330 cites W2884049795 @default.
- W4221051330 cites W2912242406 @default.
- W4221051330 cites W2913489935 @default.
- W4221051330 cites W2948003108 @default.
- W4221051330 cites W2951076599 @default.
- W4221051330 cites W2952837153 @default.
- W4221051330 cites W2963531283 @default.
- W4221051330 cites W2966352467 @default.
- W4221051330 cites W2981306529 @default.
- W4221051330 cites W2990100110 @default.
- W4221051330 cites W2997621205 @default.
- W4221051330 cites W2999312397 @default.
- W4221051330 cites W3007878186 @default.
- W4221051330 cites W3017051606 @default.
- W4221051330 cites W3040358866 @default.
- W4221051330 cites W3049052172 @default.
- W4221051330 cites W3080766772 @default.
- W4221051330 cites W3094079259 @default.
- W4221051330 cites W3121868142 @default.
- W4221051330 cites W3122229354 @default.
- W4221051330 cites W3131733728 @default.
- W4221051330 cites W3131772842 @default.
- W4221051330 cites W4242597954 @default.
- W4221051330 doi "https://doi.org/10.1016/j.biopha.2022.112837" @default.
- W4221051330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35339829" @default.
- W4221051330 hasPublicationYear "2022" @default.
- W4221051330 type Work @default.
- W4221051330 citedByCount "12" @default.
- W4221051330 countsByYear W42210513302022 @default.
- W4221051330 countsByYear W42210513302023 @default.
- W4221051330 crossrefType "journal-article" @default.
- W4221051330 hasAuthorship W4221051330A5008989251 @default.
- W4221051330 hasAuthorship W4221051330A5012613639 @default.
- W4221051330 hasAuthorship W4221051330A5013070016 @default.
- W4221051330 hasAuthorship W4221051330A5016265600 @default.
- W4221051330 hasAuthorship W4221051330A5017762928 @default.
- W4221051330 hasAuthorship W4221051330A5022540352 @default.
- W4221051330 hasAuthorship W4221051330A5034177782 @default.
- W4221051330 hasAuthorship W4221051330A5034414842 @default.
- W4221051330 hasAuthorship W4221051330A5038417134 @default.
- W4221051330 hasAuthorship W4221051330A5045073296 @default.
- W4221051330 hasAuthorship W4221051330A5047452735 @default.