FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221051593> ?p ?o ?g. }

• W4221051593 endingPage "114281" @default.
• W4221051593 startingPage "114281" @default.
• W4221051593 abstract "To synergistically treat glioma with a combination chemotherapy, we design and prepare novel cascade-targeted liposomes (Lip-TPGS) using glucose and triphenylphosphonium (TPP) as targeting moieties, which could intelligently deliver redox-sensitive doxorubicin (DOX) prodrugs (SDOX) and chemotherapeutic sensitizer lonidamine (LND). The pH-responsive ligand Chol-TPG modified by PEGylated glucose can overcome the blood-brain barrier and reach tumor cells. Combined with the modification of mitochondria targeting ligand (Chol-TPP), Lip-TPGS are endowed with pH-responsive charge regulation function and multi-stage targeting abilities. After triggered by the excessive glutathione in tumor cells, Lip-TPGS could sufficiently release the parent drugs DOX, which would significantly reduce side effects without compromising anti-glioma efficacy. Therefore, Lip-TPGS possess these characteristics: good pharmacokinetic behavior, superior brain targeting ability, specific tumor recognition and internalization capability, and strong endo/lysosome escaping and mitochondria targeting potential. Furthermore, Lip-TPGS exhibit significant advantages on anti-glioma by inhibiting proliferation, promoting apoptosis, inducing mitochondria dysfunction, inhibiting migration and invasion, prolonging the survival time, narrowing tumor areas, limiting lung metastasis, and reducing toxicity to normal organs. In summary, Lip-TPGS, with cascade targeting abilities from tissue/cell to organelle levels and highly controlled drug release properties, would become a promising drug delivery system for glioma treatment." @default.
• W4221051593 created "2022-04-03" @default.
• W4221051593 creator A5005242574 @default.
• W4221051593 creator A5007428412 @default.
• W4221051593 creator A5008715396 @default.
• W4221051593 creator A5025014865 @default.
• W4221051593 creator A5028062574 @default.
• W4221051593 creator A5040134409 @default.
• W4221051593 creator A5047778449 @default.
• W4221051593 creator A5053324964 @default.
• W4221051593 creator A5063515570 @default.
• W4221051593 creator A5069190300 @default.
• W4221051593 date "2022-05-01" @default.
• W4221051593 modified "2023-10-14" @default.
• W4221051593 title "pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma" @default.
• W4221051593 cites W1714678118 @default.
• W4221051593 cites W1968320351 @default.
• W4221051593 cites W2003526348 @default.
• W4221051593 cites W2015424171 @default.
• W4221051593 cites W2037818300 @default.
• W4221051593 cites W2041278387 @default.
• W4221051593 cites W2069193149 @default.
• W4221051593 cites W2079445254 @default.
• W4221051593 cites W2169817108 @default.
• W4221051593 cites W2408703666 @default.
• W4221051593 cites W2435053065 @default.
• W4221051593 cites W2555627105 @default.
• W4221051593 cites W2588657648 @default.
• W4221051593 cites W2592205401 @default.
• W4221051593 cites W2620069112 @default.
• W4221051593 cites W2773927148 @default.
• W4221051593 cites W2789741485 @default.
• W4221051593 cites W2885944682 @default.
• W4221051593 cites W2910943791 @default.
• W4221051593 cites W2953876961 @default.
• W4221051593 cites W2970307141 @default.
• W4221051593 cites W2974274849 @default.
• W4221051593 cites W2990485885 @default.
• W4221051593 cites W2998545905 @default.
• W4221051593 cites W3049339144 @default.
• W4221051593 cites W3096705092 @default.
• W4221051593 cites W3097523379 @default.
• W4221051593 cites W3142007849 @default.
• W4221051593 cites W3154329837 @default.
• W4221051593 cites W3165159221 @default.
• W4221051593 cites W3178241978 @default.
• W4221051593 cites W3201747807 @default.
• W4221051593 cites W3203618042 @default.
• W4221051593 cites W4200154756 @default.
• W4221051593 cites W4200404137 @default.
• W4221051593 cites W4206552053 @default.
• W4221051593 doi "https://doi.org/10.1016/j.ejmech.2022.114281" @default.
• W4221051593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35344903" @default.
• W4221051593 hasPublicationYear "2022" @default.
• W4221051593 type Work @default.
• W4221051593 citedByCount "7" @default.
• W4221051593 countsByYear W42210515932022 @default.
• W4221051593 countsByYear W42210515932023 @default.
• W4221051593 crossrefType "journal-article" @default.
• W4221051593 hasAuthorship W4221051593A5005242574 @default.
• W4221051593 hasAuthorship W4221051593A5007428412 @default.
• W4221051593 hasAuthorship W4221051593A5008715396 @default.
• W4221051593 hasAuthorship W4221051593A5025014865 @default.
• W4221051593 hasAuthorship W4221051593A5028062574 @default.
• W4221051593 hasAuthorship W4221051593A5040134409 @default.
• W4221051593 hasAuthorship W4221051593A5047778449 @default.
• W4221051593 hasAuthorship W4221051593A5053324964 @default.
• W4221051593 hasAuthorship W4221051593A5063515570 @default.
• W4221051593 hasAuthorship W4221051593A5069190300 @default.
• W4221051593 hasConcept C108215921 @default.
• W4221051593 hasConcept C109316439 @default.
• W4221051593 hasConcept C126322002 @default.
• W4221051593 hasConcept C139770010 @default.
• W4221051593 hasConcept C1491633281 @default.
• W4221051593 hasConcept C178790620 @default.
• W4221051593 hasConcept C185154212 @default.
• W4221051593 hasConcept C185592680 @default.
• W4221051593 hasConcept C202751555 @default.
• W4221051593 hasConcept C2776694085 @default.
• W4221051593 hasConcept C2778227246 @default.
• W4221051593 hasConcept C2779820397 @default.
• W4221051593 hasConcept C2781303535 @default.
• W4221051593 hasConcept C28859421 @default.
• W4221051593 hasConcept C502942594 @default.
• W4221051593 hasConcept C55493867 @default.
• W4221051593 hasConcept C71924100 @default.
• W4221051593 hasConcept C98274493 @default.
• W4221051593 hasConceptScore W4221051593C108215921 @default.
• W4221051593 hasConceptScore W4221051593C109316439 @default.
• W4221051593 hasConceptScore W4221051593C126322002 @default.
• W4221051593 hasConceptScore W4221051593C139770010 @default.
• W4221051593 hasConceptScore W4221051593C1491633281 @default.
• W4221051593 hasConceptScore W4221051593C178790620 @default.
• W4221051593 hasConceptScore W4221051593C185154212 @default.
• W4221051593 hasConceptScore W4221051593C185592680 @default.
• W4221051593 hasConceptScore W4221051593C202751555 @default.
• W4221051593 hasConceptScore W4221051593C2776694085 @default.
• W4221051593 hasConceptScore W4221051593C2778227246 @default.

• next