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- W4221053032 abstract "Here, we disclose the divergent total syntheses of representative C18-oxo eburnamine-vincamine alkaloids (+)-eburnaminol, (-)-larutenine, and (-)-cuanzine. Key to the approach is a substrate-controlled iridium-catalyzed asymmetric hydrogenation/lactamization cascade that leads to the formation of the common tetracyclic skeleton with essential cis-C20/C21 stereochemistry (93% yield, 98% ee, >20:1 dr, gram scale). Access to the targeted alkaloids is effected late in the synthesis by implementation of a number of diversity-oriented transformations and late-stage modifications." @default.
- W4221053032 created "2022-04-03" @default.
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- W4221053032 date "2022-03-21" @default.
- W4221053032 modified "2023-10-01" @default.
- W4221053032 title "Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids" @default.
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- W4221053032 doi "https://doi.org/10.1021/acs.orglett.2c00661" @default.
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