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• W4221053592 abstract "Saccharomyces cerevisiae is increasingly being used for the production of chemicals derived from acetyl coenzyme A (acetyl-CoA). However, the inadequate supply of cytosolic acetyl-CoA often leads to low yields. Here, we developed a novel strategy for balancing acetyl-CoA metabolism and increasing the amount of the downstream product. First, the combination of acetaldehyde dehydrogenase (eutE) and acetoacetyl-CoA thiolase (AtoB) was optimized to redirect the acetyl-CoA flux toward the target pathway, with a 21-fold improvement in mevalonic acid production. Second, pathway engineering and evolutionary engineering were conducted to attenuate the growth deficiency, and a 10-fold improvement of the maximum productivity was achieved. Third, acetyl-CoA carboxylase (ACC1) was dynamically downregulated as the complementary acetyl-CoA pathway, and the yield was improved more than twofold. Fourth, the most efficient and complementary acetyl-CoA pathways were combined, and the final strain produced 68 mg/g CDW lycopene, which was among the highest yields reported in S. cerevisiae. This study demonstrates a new method of producing lycopene products by regulating acetyl-CoA metabolism." @default.
• W4221053592 created "2022-04-03" @default.
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• W4221053592 date "2022-03-23" @default.
• W4221053592 modified "2023-10-09" @default.
• W4221053592 title "Engineering a Balanced Acetyl Coenzyme A Metabolism in <i>Saccharomyces cerevisiae</i> for Lycopene Production through Rational and Evolutionary Engineering" @default.
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• W4221053592 doi "https://doi.org/10.1021/acs.jafc.2c00531" @default.
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