FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221054908> ?p ?o ?g. }

• W4221054908 endingPage "434" @default.
• W4221054908 startingPage "434" @default.
• W4221054908 abstract "Background and Objectives: Human dental pulp cells (HDPCs) can be used for dentin regeneration due to its odontogenic differentiation property. Icariin can induce osteogenic differentiation of stem cells. However, its potential to induce odontogenic differentiation of HDPCs remains unclear. Thus, the aim of this study was to evaluate the capacity of icariin to induce odontogenic differentiation of HDPCs and investigate the underlying molecular mechanism. Materials and Methods: Cell viability assay was used to detect the cytotoxicity of icariin to HDPCs. Effect of icariin on HDPCs chemotaxis was measured by scratch migration assay. The mineralized and odontogenic differentiation of HDPCs was assessed by alkaline phosphatase (ALP) staining, alizarin red S (ARS) staining, real-time PCR, and Western blot of dentin matrix protein 1 (DMP 1) and dentin sialophosphoprotein (DSPP). In addition, Mitogen-activated protein kinase (MAPK) signaling pathway of icariin-induced biomineralization was investigated by Western blot. Results: Cells treated with icariin at all concentrations tested maintained viability, indicating that icariin was biocompatible. Icariin accelerated HDPCs chemotaxis (p < 0.05). Expression levels of related odontogenic markers were increased in the presence of icariin (p < 0.05). Icariin-induced odontogenic differentiation occurred via activation of the MAPK signaling pathway. Furthermore, MAPK inhibitors suppressed expression levels of DSPP and DMP 1 protein, ALP activity, and mineralization of HDPCs. Conclusions: Icariin can upregulate odontogenic differentiation of HDPCs by triggering the MAPK signaling pathway." @default.
• W4221054908 created "2022-04-03" @default.
• W4221054908 creator A5044866373 @default.
• W4221054908 creator A5045545554 @default.
• W4221054908 creator A5055446149 @default.
• W4221054908 creator A5080571005 @default.
• W4221054908 creator A5081759932 @default.
• W4221054908 date "2022-03-16" @default.
• W4221054908 modified "2023-09-30" @default.
• W4221054908 title "Odontogenic Effect of Icariin on the Human Dental Pulp Cells" @default.
• W4221054908 cites W2000883906 @default.
• W4221054908 cites W2011371855 @default.
• W4221054908 cites W2017870767 @default.
• W4221054908 cites W2023167090 @default.
• W4221054908 cites W2037445947 @default.
• W4221054908 cites W2048359095 @default.
• W4221054908 cites W2060211276 @default.
• W4221054908 cites W2063328952 @default.
• W4221054908 cites W2064369032 @default.
• W4221054908 cites W2066113694 @default.
• W4221054908 cites W2126983480 @default.
• W4221054908 cites W2138284463 @default.
• W4221054908 cites W2150026598 @default.
• W4221054908 cites W2168535055 @default.
• W4221054908 cites W2256070306 @default.
• W4221054908 cites W2507601657 @default.
• W4221054908 cites W2765285912 @default.
• W4221054908 cites W2767402457 @default.
• W4221054908 cites W2790046850 @default.
• W4221054908 cites W2810284427 @default.
• W4221054908 cites W2883653852 @default.
• W4221054908 cites W2886770780 @default.
• W4221054908 cites W2891029032 @default.
• W4221054908 cites W2893058683 @default.
• W4221054908 cites W2938397529 @default.
• W4221054908 cites W2946231488 @default.
• W4221054908 cites W2949356248 @default.
• W4221054908 cites W2970085321 @default.
• W4221054908 cites W2972897928 @default.
• W4221054908 cites W2981123327 @default.
• W4221054908 cites W2987592925 @default.
• W4221054908 cites W3026998210 @default.
• W4221054908 cites W3037495118 @default.
• W4221054908 cites W3042563821 @default.
• W4221054908 cites W3093914780 @default.
• W4221054908 cites W3100960927 @default.
• W4221054908 cites W3108770488 @default.
• W4221054908 cites W3119900818 @default.
• W4221054908 doi "https://doi.org/10.3390/medicina58030434" @default.
• W4221054908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35334610" @default.
• W4221054908 hasPublicationYear "2022" @default.
• W4221054908 type Work @default.
• W4221054908 citedByCount "1" @default.
• W4221054908 countsByYear W42210549082023 @default.
• W4221054908 crossrefType "journal-article" @default.
• W4221054908 hasAuthorship W4221054908A5044866373 @default.
• W4221054908 hasAuthorship W4221054908A5045545554 @default.
• W4221054908 hasAuthorship W4221054908A5055446149 @default.
• W4221054908 hasAuthorship W4221054908A5080571005 @default.
• W4221054908 hasAuthorship W4221054908A5081759932 @default.
• W4221054908 hasBestOaLocation W42210549081 @default.
• W4221054908 hasConcept C104317684 @default.
• W4221054908 hasConcept C142724271 @default.
• W4221054908 hasConcept C1491633281 @default.
• W4221054908 hasConcept C153911025 @default.
• W4221054908 hasConcept C160160445 @default.
• W4221054908 hasConcept C181199279 @default.
• W4221054908 hasConcept C185592680 @default.
• W4221054908 hasConcept C188442228 @default.
• W4221054908 hasConcept C199343813 @default.
• W4221054908 hasConcept C204787440 @default.
• W4221054908 hasConcept C2776415932 @default.
• W4221054908 hasConcept C2779203663 @default.
• W4221054908 hasConcept C2780685212 @default.
• W4221054908 hasConcept C53227056 @default.
• W4221054908 hasConcept C55493867 @default.
• W4221054908 hasConcept C57074206 @default.
• W4221054908 hasConcept C62478195 @default.
• W4221054908 hasConcept C71924100 @default.
• W4221054908 hasConcept C86803240 @default.
• W4221054908 hasConcept C95444343 @default.
• W4221054908 hasConceptScore W4221054908C104317684 @default.
• W4221054908 hasConceptScore W4221054908C142724271 @default.
• W4221054908 hasConceptScore W4221054908C1491633281 @default.
• W4221054908 hasConceptScore W4221054908C153911025 @default.
• W4221054908 hasConceptScore W4221054908C160160445 @default.
• W4221054908 hasConceptScore W4221054908C181199279 @default.
• W4221054908 hasConceptScore W4221054908C185592680 @default.
• W4221054908 hasConceptScore W4221054908C188442228 @default.
• W4221054908 hasConceptScore W4221054908C199343813 @default.
• W4221054908 hasConceptScore W4221054908C204787440 @default.
• W4221054908 hasConceptScore W4221054908C2776415932 @default.
• W4221054908 hasConceptScore W4221054908C2779203663 @default.
• W4221054908 hasConceptScore W4221054908C2780685212 @default.
• W4221054908 hasConceptScore W4221054908C53227056 @default.
• W4221054908 hasConceptScore W4221054908C55493867 @default.
• W4221054908 hasConceptScore W4221054908C57074206 @default.
• W4221054908 hasConceptScore W4221054908C62478195 @default.

• next