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- W4221055043 abstract "Abstract Background Intragastric administration of virulent Rhodococcus equi protects foals against subsequent experimental intrabronchial (IB) infection, but it is unknown whether R. equi naturally ingested by foals contributes to their susceptibility to pneumonia. Hypothesis Fecal concentration of virulent R. equi before IB infection with R. equi is positively associated with protection from pneumonia in foals. Animals Twenty‐one university‐owned foals. Methods Samples were collected from experimental studies. Five foals were gavaged with live, virulent R. equi (LVRE) at age 2 and 4 days; the remaining 16 foals were not gavaged with LVRE (controls). Fecal swabs were collected from foals at ages 28 days, immediately before IB infection. Foals were monitored for clinical signs of pneumonia, and fecal swabs were collected approximately 2 weeks after IB infection. Swabs were tested by quantitative PCR for concentration of virulent R. equi (ie, copy numbers of the virulence‐associated protein A gene [ vapA ] per 100 ng fecal DNA). Results Fecal concentrations of virulent R. equi ( vapA ) before IB infection were significantly ( P < .05) lower in control foals (25 copies/100 ng DNA [95% CI, 5 to 118 copies/100 ng DNA) that developed pneumonia (n = 8) than in healthy control foals (n = 8; 280 copies/100 ng DNA; 95% CI, 30 to 2552 copies/100 ng DNA) or those gavaged with LVRE (707 copies/100 ng DNA, 95% CI, 54 to 9207 copies/100 ng DNA). Conclusions and Clinical Importance Greater natural ingestion of LVRE might contribute to protection against pneumonia among foals." @default.
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- W4221055043 date "2022-03-24" @default.
- W4221055043 modified "2023-09-26" @default.
- W4221055043 title "Association of pneumonia with concentrations of virulent <i>Rhodococcus equi</i> in fecal swabs of foals before and after intrabronchial infection with virulent <i>R. equi</i>" @default.
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- W4221055043 doi "https://doi.org/10.1111/jvim.16409" @default.
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