FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221055046> ?p ?o ?g. }

• W4221055046 endingPage "574" @default.
• W4221055046 startingPage "561" @default.
• W4221055046 abstract "Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the disease, often during its asymptomatic phase. Current practice in treatment and recurrence monitoring is based primarily on pathological evaluations but can also encompass genomic evaluations, both of which focus on the primary tumor. Although breast cancer is one of the most studied cancers, patients still recur at a rate of up to 15% within the first 10 years post-surgery. Local recurrence was originally attributed to tumor cells contaminating histologically normal (HN) tissues beyond the surgical margin, but advances in technology have allowed for the identification of distinct aberrations that exist in the peri-tumoral tissues themselves. One leading theory to explain this phenomenon is the field cancerization theory. Under this hypothesis, tumors arise from a field of molecularly altered cells that create a permissive environment for malignant evolution, which can occur with or without morphological changes. The traditional histopathology paradigm dictates that molecular alterations are reflected in the tissue phenotype. However, the spectrum of inter-patient variability of normal breast tissue may obfuscate recognition of a cancerized field during routine diagnostics. In this review, we explore the concept of field cancerization focusing on HN peri-tumoral tissues: we present the pathological and molecular features of field cancerization within these tissues and discuss how the use of peri-tumoral tissues can affect research. Our observations suggest that pathological and molecular evaluations could be used synergistically to assess risk and guide the therapeutic management of patients. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland." @default.
• W4221055046 created "2022-04-03" @default.
• W4221055046 creator A5006596495 @default.
• W4221055046 creator A5021388730 @default.
• W4221055046 creator A5041936805 @default.
• W4221055046 creator A5066580354 @default.
• W4221055046 creator A5072249752 @default.
• W4221055046 date "2022-05-03" @default.
• W4221055046 modified "2023-09-26" @default.
• W4221055046 title "Field cancerization in breast cancer" @default.
• W4221055046 cites W1485748895 @default.
• W4221055046 cites W1841030365 @default.
• W4221055046 cites W1930047873 @default.
• W4221055046 cites W1965038309 @default.
• W4221055046 cites W1970668319 @default.
• W4221055046 cites W1978351270 @default.
• W4221055046 cites W1979508540 @default.
• W4221055046 cites W1981268896 @default.
• W4221055046 cites W1984825803 @default.
• W4221055046 cites W1989607209 @default.
• W4221055046 cites W1991949008 @default.
• W4221055046 cites W1994365672 @default.
• W4221055046 cites W1997001969 @default.
• W4221055046 cites W1997655151 @default.
• W4221055046 cites W1998926479 @default.
• W4221055046 cites W2002978719 @default.
• W4221055046 cites W2007227595 @default.
• W4221055046 cites W2008479759 @default.
• W4221055046 cites W2018486347 @default.
• W4221055046 cites W2019310175 @default.
• W4221055046 cites W2024377014 @default.
• W4221055046 cites W2034813342 @default.
• W4221055046 cites W2040867063 @default.
• W4221055046 cites W2041988832 @default.
• W4221055046 cites W2046194218 @default.
• W4221055046 cites W2051372177 @default.
• W4221055046 cites W2071441216 @default.
• W4221055046 cites W2074801231 @default.
• W4221055046 cites W2076061584 @default.
• W4221055046 cites W2076399666 @default.
• W4221055046 cites W2082458892 @default.
• W4221055046 cites W2097024234 @default.
• W4221055046 cites W2097935031 @default.
• W4221055046 cites W2099302252 @default.
• W4221055046 cites W2100303404 @default.
• W4221055046 cites W2101741797 @default.
• W4221055046 cites W2104479723 @default.
• W4221055046 cites W2108184788 @default.
• W4221055046 cites W2108201031 @default.
• W4221055046 cites W2111061352 @default.
• W4221055046 cites W2111471316 @default.
• W4221055046 cites W2111627225 @default.
• W4221055046 cites W2113009178 @default.
• W4221055046 cites W2124870706 @default.
• W4221055046 cites W2125442671 @default.
• W4221055046 cites W2127002994 @default.
• W4221055046 cites W2129175864 @default.
• W4221055046 cites W2134252850 @default.
• W4221055046 cites W2140575188 @default.
• W4221055046 cites W2145371947 @default.
• W4221055046 cites W2146112009 @default.
• W4221055046 cites W2150959753 @default.
• W4221055046 cites W2152582581 @default.
• W4221055046 cites W2157214221 @default.
• W4221055046 cites W2159144282 @default.
• W4221055046 cites W2161116593 @default.
• W4221055046 cites W2162307063 @default.
• W4221055046 cites W2162612703 @default.
• W4221055046 cites W2165664908 @default.
• W4221055046 cites W2231580835 @default.
• W4221055046 cites W2262529275 @default.
• W4221055046 cites W2269399094 @default.
• W4221055046 cites W2291499494 @default.
• W4221055046 cites W2346853311 @default.
• W4221055046 cites W2346938215 @default.
• W4221055046 cites W2465175609 @default.
• W4221055046 cites W2476542314 @default.
• W4221055046 cites W2483210912 @default.
• W4221055046 cites W2493607481 @default.
• W4221055046 cites W250128136 @default.
• W4221055046 cites W2529271376 @default.
• W4221055046 cites W2558180135 @default.
• W4221055046 cites W2568452620 @default.
• W4221055046 cites W2589099231 @default.
• W4221055046 cites W2617184869 @default.
• W4221055046 cites W2724571272 @default.
• W4221055046 cites W2754701143 @default.
• W4221055046 cites W2763305333 @default.
• W4221055046 cites W2766676715 @default.
• W4221055046 cites W2767028732 @default.
• W4221055046 cites W2772014076 @default.
• W4221055046 cites W2774841093 @default.
• W4221055046 cites W2783674487 @default.
• W4221055046 cites W2801011555 @default.
• W4221055046 cites W2801892046 @default.
• W4221055046 cites W2805816192 @default.
• W4221055046 cites W2906555241 @default.
• W4221055046 cites W2908549984 @default.

• next