FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221062056> ?p ?o ?g. }

• W4221062056 endingPage "e222687" @default.
• W4221062056 startingPage "e222687" @default.
• W4221062056 abstract "<h3>Importance</h3> Familial hypercholesterolemia variants impair clearance of cholesterol from the circulation and increase risk of coronary artery disease (CAD). The extent to which adherence to a healthy lifestyle is associated with a lower risk of CAD in carriers and noncarriers of variants warrants further study. <h3>Objective</h3> To assess the association of the interaction between familial hypercholesterolemia variants and adherence to a healthy lifestyle with risk of CAD. <h3>Design, Setting, and Participants</h3> This cross-sectional study used 2 independent data sets with gene sequencing and lifestyle data from the UK Biobank: a case-control study of 4896 cases and 5279 controls and a cohort study of 39 920 participants. Participants were recruited from 22 sites across the UK between March 21, 2006, and October 1, 2010. The case-control study included participants with CAD and controls at enrollment. The cohort study used a convenience sample of individuals with available gene sequencing data. Statistical analysis was performed from April 2, 2019, to January 20, 2022. <h3>Exposures</h3> Pathogenic or likely pathogenic DNA variants classified by a clinical laboratory geneticist and adherence to a healthy lifestyle based on a 4-point scoring system (1 point for each of the following: healthy diet, regular exercise, not smoking, and absence of obesity). <h3>Main Outcomes and Measures</h3> Coronary artery disease, defined as myocardial infarction in the case-control study, and myocardial infarction, ischemic heart disease, or coronary revascularization procedure in the cohort study. <h3>Results</h3> The case-control study included 10 175 participants (6828 men [67.1%]; mean [SD] age, 58.6 [7.2] years), and the cohort study included 39 920 participants (18 802 men [47.1%]; mean [SD] age at the end of follow-up, 66.4 [8.0] years). A variant was identified in 35 of 4896 cases (0.7%) and 12 of 5279 controls (0.2%), corresponding to an odds ratio of 3.0 (95% CI, 1.6-5.9), and a variant was identified in 108 individuals (0.3%) in the cohort study, in which the hazard ratio for CAD was 3.8 (95% CI, 2.5-5.8). However, this risk appeared to vary according to lifestyle categories in both carriers and noncarriers of familial hypercholesterolemia variants, without a significant interaction between carrier status and lifestyle (odds ratio, 1.2 [95% CI, 0.6-2.5];<i>P</i> = .62). Among carriers, a favorable lifestyle conferred 86% lower risk of CAD compared with an unfavorable lifestyle (hazard ratio, 0.14 [95% CI, 0.04-0.41]). The estimated risk of CAD by the age of 75 years varied according to lifestyle, ranging from 10.2% among noncarriers with a favorable lifestyle to 24.0% among noncarriers with an unfavorable lifestyle and ranging from 34.5% among carriers with a favorable lifestyle to 66.2% among carriers with an unfavorable lifestyle. <h3>Conclusions and Relevance</h3> This study suggests that, among carriers and noncarriers of a familial hypercholesterolemia variant, significant gradients in risk of CAD are noted according to adherence to a healthy lifestyle pattern. Similar to the general population, individuals who carry familial hypercholesterolemia variants are likely to benefit from lifestyle interventions to reduce their risk of CAD." @default.
• W4221062056 created "2022-04-03" @default.
• W4221062056 creator A5006649339 @default.
• W4221062056 creator A5014697238 @default.
• W4221062056 creator A5017243866 @default.
• W4221062056 creator A5034174255 @default.
• W4221062056 creator A5043295370 @default.
• W4221062056 creator A5054679219 @default.
• W4221062056 creator A5069822855 @default.
• W4221062056 creator A5070430680 @default.
• W4221062056 creator A5072824736 @default.
• W4221062056 creator A5076448230 @default.
• W4221062056 creator A5077181516 @default.
• W4221062056 date "2022-03-16" @default.
• W4221062056 modified "2023-10-14" @default.
• W4221062056 title "Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease" @default.
• W4221062056 cites W1539286846 @default.
• W4221062056 cites W1551914601 @default.
• W4221062056 cites W1844854928 @default.
• W4221062056 cites W1976844911 @default.
• W4221062056 cites W2016805353 @default.
• W4221062056 cites W2033879310 @default.
• W4221062056 cites W2045040642 @default.
• W4221062056 cites W2051978340 @default.
• W4221062056 cites W2105612671 @default.
• W4221062056 cites W2125360578 @default.
• W4221062056 cites W2138158271 @default.
• W4221062056 cites W2142648409 @default.
• W4221062056 cites W2156848121 @default.
• W4221062056 cites W2157752701 @default.
• W4221062056 cites W2165624352 @default.
• W4221062056 cites W2171129594 @default.
• W4221062056 cites W2226817873 @default.
• W4221062056 cites W2234524676 @default.
• W4221062056 cites W2275737843 @default.
• W4221062056 cites W2304142550 @default.
• W4221062056 cites W2309226912 @default.
• W4221062056 cites W2405171365 @default.
• W4221062056 cites W2410774145 @default.
• W4221062056 cites W2549881333 @default.
• W4221062056 cites W2567297878 @default.
• W4221062056 cites W2584109479 @default.
• W4221062056 cites W2620146310 @default.
• W4221062056 cites W2723723801 @default.
• W4221062056 cites W2753325383 @default.
• W4221062056 cites W2810806985 @default.
• W4221062056 cites W2885745997 @default.
• W4221062056 cites W2887629426 @default.
• W4221062056 cites W2890138630 @default.
• W4221062056 cites W2890689490 @default.
• W4221062056 cites W2895486342 @default.
• W4221062056 cites W2900726805 @default.
• W4221062056 cites W2901308462 @default.
• W4221062056 cites W2901728784 @default.
• W4221062056 cites W2903609570 @default.
• W4221062056 cites W2921012991 @default.
• W4221062056 cites W2951672808 @default.
• W4221062056 cites W2973113902 @default.
• W4221062056 cites W2995479243 @default.
• W4221062056 cites W3005689325 @default.
• W4221062056 cites W3020378214 @default.
• W4221062056 cites W3024375461 @default.
• W4221062056 cites W3025340824 @default.
• W4221062056 cites W3052902836 @default.
• W4221062056 cites W3119797572 @default.
• W4221062056 cites W3123691613 @default.
• W4221062056 cites W3128047326 @default.
• W4221062056 cites W4205170775 @default.
• W4221062056 cites W4210347219 @default.
• W4221062056 cites W4285719527 @default.
• W4221062056 cites W4288076330 @default.
• W4221062056 doi "https://doi.org/10.1001/jamanetworkopen.2022.2687" @default.
• W4221062056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35294538" @default.
• W4221062056 hasPublicationYear "2022" @default.
• W4221062056 type Work @default.
• W4221062056 citedByCount "12" @default.
• W4221062056 countsByYear W42210620562022 @default.
• W4221062056 countsByYear W42210620562023 @default.
• W4221062056 crossrefType "journal-article" @default.
• W4221062056 hasAuthorship W4221062056A5006649339 @default.
• W4221062056 hasAuthorship W4221062056A5014697238 @default.
• W4221062056 hasAuthorship W4221062056A5017243866 @default.
• W4221062056 hasAuthorship W4221062056A5034174255 @default.
• W4221062056 hasAuthorship W4221062056A5043295370 @default.
• W4221062056 hasAuthorship W4221062056A5054679219 @default.
• W4221062056 hasAuthorship W4221062056A5069822855 @default.
• W4221062056 hasAuthorship W4221062056A5070430680 @default.
• W4221062056 hasAuthorship W4221062056A5072824736 @default.
• W4221062056 hasAuthorship W4221062056A5076448230 @default.
• W4221062056 hasAuthorship W4221062056A5077181516 @default.
• W4221062056 hasBestOaLocation W42210620561 @default.
• W4221062056 hasConcept C116567970 @default.
• W4221062056 hasConcept C126322002 @default.
• W4221062056 hasConcept C164705383 @default.
• W4221062056 hasConcept C1862650 @default.
• W4221062056 hasConcept C201903717 @default.
• W4221062056 hasConcept C2778163477 @default.
• W4221062056 hasConcept C2778213512 @default.

• next