FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221065780> ?p ?o ?g. }

• W4221065780 endingPage "738133" @default.
• W4221065780 startingPage "738133" @default.
• W4221065780 abstract "The goal of this research was to explore the detoxification metabolic pathway and regulatory mechanism of the cuttlefish ( Sepia pharaonis ) under ammonia nitrogen stress. This study investigated the ammonia and urea contents in the hemolymph and liver and the amino acid contents in the liver using high-performance liquid chromatography (HPLC) and examined the changes in the activities and mRNA expression of key enzymes in the ammonia nitrogen metabolic pathway under different ammonia nitrogen stress concentrations (1 mg/L, 3 mg/L, 6 mg/L and 12 mg/L). The main conclusion was that the key indices of the urea metabolic pathway showed obvious time-concentration effects under ammonia nitrogen stress. An ornithine-urea cycle metabolic pathway was confirmed to exist in cuttlefish at the transcriptional and metabolic levels. Under low ammonia nitrogen stress, cuttlefish can detoxify ammonia nitrogen into urea through urea metabolism. However, the metabolic pathway of the urea cycle is inhibited under high ammonia nitrogen stress (≥12 mg/L). Second, under ammonia nitrogen stress, the contents of glutamine, taurine, proline, glycine (except under high concentration stress), citrulline and tyrosine in the liver tissue increased significantly ( P < 0.05). Aspartic acid and alanine initially increased and then decreased with the concentration of ammonia nitrogen. In summary, under ammonia nitrogen stress, cuttlefish may utilize the urea and amino acid metabolic pathways. Converting ammonia nitrogen to urea and amino acids (glutamine, taurine, proline, glycine, aspartic acid, alanine, citrulline and tyrosine) reduces the ammonia nitrogen content in the body. However, under high ammonia nitrogen stress, the urea cycle pathway and some amino acid metabolic pathways (such as aspartic acid and alanine) are inhibited. • Cuttlefish can detoxify ammonia nitrogen into urea through the ornithine-urea cycle. • Cuttlefish can adapt to adverse stress through positive responses in amino acid metabolic pathways. • Under high ammonia nitrogen stress, the urea cycle pathway and some amino acid metabolic pathways (such as aspartic acid and alanine) were inhibited." @default.
• W4221065780 created "2022-04-03" @default.
• W4221065780 creator A5024453839 @default.
• W4221065780 creator A5024870796 @default.
• W4221065780 creator A5037662754 @default.
• W4221065780 creator A5038199566 @default.
• W4221065780 creator A5038678131 @default.
• W4221065780 creator A5055873969 @default.
• W4221065780 creator A5078632164 @default.
• W4221065780 date "2022-05-01" @default.
• W4221065780 modified "2023-09-30" @default.
• W4221065780 title "Effect of ammonia nitrogen on the detoxification metabolic pathway of cuttlefish (Sepia pharaonis)" @default.
• W4221065780 cites W1953697071 @default.
• W4221065780 cites W1974574067 @default.
• W4221065780 cites W1979709962 @default.
• W4221065780 cites W1981130688 @default.
• W4221065780 cites W1985584222 @default.
• W4221065780 cites W1985596566 @default.
• W4221065780 cites W1993580795 @default.
• W4221065780 cites W2004171427 @default.
• W4221065780 cites W2004417645 @default.
• W4221065780 cites W2004492757 @default.
• W4221065780 cites W2007609812 @default.
• W4221065780 cites W2008481607 @default.
• W4221065780 cites W2011174591 @default.
• W4221065780 cites W2018934645 @default.
• W4221065780 cites W2028778207 @default.
• W4221065780 cites W2031086151 @default.
• W4221065780 cites W2040380009 @default.
• W4221065780 cites W2049970199 @default.
• W4221065780 cites W2050953904 @default.
• W4221065780 cites W2056296836 @default.
• W4221065780 cites W2058343116 @default.
• W4221065780 cites W2062261652 @default.
• W4221065780 cites W2066711747 @default.
• W4221065780 cites W2071132243 @default.
• W4221065780 cites W2076706231 @default.
• W4221065780 cites W2090636285 @default.
• W4221065780 cites W2091934331 @default.
• W4221065780 cites W2092193353 @default.
• W4221065780 cites W2105725786 @default.
• W4221065780 cites W2172958108 @default.
• W4221065780 cites W2333874708 @default.
• W4221065780 cites W2946581505 @default.
• W4221065780 cites W3127769858 @default.
• W4221065780 cites W3156981325 @default.
• W4221065780 cites W4248237722 @default.
• W4221065780 doi "https://doi.org/10.1016/j.aquaculture.2022.738133" @default.
• W4221065780 hasPublicationYear "2022" @default.
• W4221065780 type Work @default.
• W4221065780 citedByCount "4" @default.
• W4221065780 countsByYear W42210657802022 @default.
• W4221065780 countsByYear W42210657802023 @default.
• W4221065780 crossrefType "journal-article" @default.
• W4221065780 hasAuthorship W4221065780A5024453839 @default.
• W4221065780 hasAuthorship W4221065780A5024870796 @default.
• W4221065780 hasAuthorship W4221065780A5037662754 @default.
• W4221065780 hasAuthorship W4221065780A5038199566 @default.
• W4221065780 hasAuthorship W4221065780A5038678131 @default.
• W4221065780 hasAuthorship W4221065780A5055873969 @default.
• W4221065780 hasAuthorship W4221065780A5078632164 @default.
• W4221065780 hasConcept C121332964 @default.
• W4221065780 hasConcept C142724271 @default.
• W4221065780 hasConcept C18903297 @default.
• W4221065780 hasConcept C204787440 @default.
• W4221065780 hasConcept C2776382133 @default.
• W4221065780 hasConcept C2779790239 @default.
• W4221065780 hasConcept C2780438927 @default.
• W4221065780 hasConcept C2780497538 @default.
• W4221065780 hasConcept C2780886089 @default.
• W4221065780 hasConcept C45326173 @default.
• W4221065780 hasConcept C505870484 @default.
• W4221065780 hasConcept C537208039 @default.
• W4221065780 hasConcept C55493867 @default.
• W4221065780 hasConcept C59822182 @default.
• W4221065780 hasConcept C62520636 @default.
• W4221065780 hasConcept C71924100 @default.
• W4221065780 hasConcept C86803240 @default.
• W4221065780 hasConcept C90856448 @default.
• W4221065780 hasConceptScore W4221065780C121332964 @default.
• W4221065780 hasConceptScore W4221065780C142724271 @default.
• W4221065780 hasConceptScore W4221065780C18903297 @default.
• W4221065780 hasConceptScore W4221065780C204787440 @default.
• W4221065780 hasConceptScore W4221065780C2776382133 @default.
• W4221065780 hasConceptScore W4221065780C2779790239 @default.
• W4221065780 hasConceptScore W4221065780C2780438927 @default.
• W4221065780 hasConceptScore W4221065780C2780497538 @default.
• W4221065780 hasConceptScore W4221065780C2780886089 @default.
• W4221065780 hasConceptScore W4221065780C45326173 @default.
• W4221065780 hasConceptScore W4221065780C505870484 @default.
• W4221065780 hasConceptScore W4221065780C537208039 @default.
• W4221065780 hasConceptScore W4221065780C55493867 @default.
• W4221065780 hasConceptScore W4221065780C59822182 @default.
• W4221065780 hasConceptScore W4221065780C62520636 @default.
• W4221065780 hasConceptScore W4221065780C71924100 @default.
• W4221065780 hasConceptScore W4221065780C86803240 @default.
• W4221065780 hasConceptScore W4221065780C90856448 @default.
• W4221065780 hasLocation W42210657801 @default.

• next