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- W4221066899 abstract "Schizophrenia is a substantially heritable, debilitating brain syndrome, that affects almost 1% of adults at some point in their lives. Current therapies, which all target the dopamine D2 receptor, effectively treat psychotic symptoms but have little impact on the behavioral and cognitive deficits associated with poorer functional outcomes. In this chapter, we review the genetic epidemiology of schizophrenia and how recent genome-wide association studies and genome sequencing are helping us to reconceptualize the condition. Emerging is a complex genetic architecture involving a spectrum of risk variants, from common to rare, and underlying molecular etiology shared with other psychiatric disorders. The implicated biology includes immune function, glutamatergic neurotransmission, calcium channel function, and synaptic plasticity. We consider the next research steps to be taken and how this work may affect diagnosis, drug discovery, and personalized care for people with schizophrenia in the future." @default.
- W4221066899 created "2022-04-03" @default.
- W4221066899 creator A5004359887 @default.
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- W4221066899 creator A5077000076 @default.
- W4221066899 date "2022-01-01" @default.
- W4221066899 modified "2023-10-18" @default.
- W4221066899 title "Schizophrenia genomics" @default.
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