Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221072539> ?p ?o ?g. }
- W4221072539 endingPage "4007" @default.
- W4221072539 startingPage "3991" @default.
- W4221072539 abstract "Abstract Multiple disease resistance (MDR) in maize has attracted increasing attention. However, the interplay between cell death and metabolite changes and their contributions to MDR remains elusive in maize. In this study, we identified a mutant named as lesion mimic 30 (les30) that showed ‘suicidal’ lesion formation in the absence of disease and had enhanced resistance to the fungal pathogen Curvularia lunata. Using map-based cloning, we identified the causal gene encoding pheophorbide a oxidase (PAO), which is known to be involved in chlorophyll degradation and MDR, and is encoded by LETHAL LEAF SPOT1 (LLS1). LLS1 was found to be induced by both biotic and abiotic stresses. Transcriptomics analysis showed that genes involved in defense responses and secondary metabolite biosynthesis were mildly activated in leaves of the les30 mutant without lesions, whilst they were strongly activated in leaves with lesions. In addition, in les30 leaves with lesions, there was overaccumulation of defense-associated phytohormones including jasmonic acid and salicylic acid, and of phytoalexins including phenylpropanoids, lignin, and flavonoids, suggesting that their biosynthesis was activated in a lesion-dependent manner. Taken together, our study implies the existence of an interactive amplification loop of interrupted chlorophyll degradation, cell death, expression of defense-related genes, and metabolite changes that results in suicidal lesion formation and MDR, and this has the potential to be exploited by genetic manipulation to improve maize disease resistance." @default.
- W4221072539 created "2022-04-03" @default.
- W4221072539 creator A5002954787 @default.
- W4221072539 creator A5013661587 @default.
- W4221072539 creator A5015001687 @default.
- W4221072539 creator A5018863416 @default.
- W4221072539 creator A5035211272 @default.
- W4221072539 creator A5037610772 @default.
- W4221072539 creator A5045372491 @default.
- W4221072539 creator A5047334327 @default.
- W4221072539 creator A5048225670 @default.
- W4221072539 creator A5058382236 @default.
- W4221072539 creator A5063761902 @default.
- W4221072539 creator A5064554724 @default.
- W4221072539 creator A5069050873 @default.
- W4221072539 creator A5071418683 @default.
- W4221072539 creator A5079415041 @default.
- W4221072539 date "2022-03-18" @default.
- W4221072539 modified "2023-10-16" @default.
- W4221072539 title "Underlying mechanism of accelerated cell death and multiple disease resistance in a maize <i>lethal leaf spot 1</i> allele" @default.
- W4221072539 cites W1529774866 @default.
- W4221072539 cites W1963542738 @default.
- W4221072539 cites W1963548757 @default.
- W4221072539 cites W1967101821 @default.
- W4221072539 cites W1968883627 @default.
- W4221072539 cites W1969676666 @default.
- W4221072539 cites W1969686976 @default.
- W4221072539 cites W1976616030 @default.
- W4221072539 cites W1990473745 @default.
- W4221072539 cites W1995554288 @default.
- W4221072539 cites W2005587139 @default.
- W4221072539 cites W2019045963 @default.
- W4221072539 cites W2026339664 @default.
- W4221072539 cites W2028299221 @default.
- W4221072539 cites W2031551445 @default.
- W4221072539 cites W2032679613 @default.
- W4221072539 cites W2071762385 @default.
- W4221072539 cites W2072715465 @default.
- W4221072539 cites W2086688120 @default.
- W4221072539 cites W2090469736 @default.
- W4221072539 cites W2098014840 @default.
- W4221072539 cites W2102278945 @default.
- W4221072539 cites W2102712594 @default.
- W4221072539 cites W2107277218 @default.
- W4221072539 cites W2107536885 @default.
- W4221072539 cites W2110229779 @default.
- W4221072539 cites W2114425137 @default.
- W4221072539 cites W2114872392 @default.
- W4221072539 cites W2140554168 @default.
- W4221072539 cites W2143014195 @default.
- W4221072539 cites W2147386792 @default.
- W4221072539 cites W2150638145 @default.
- W4221072539 cites W2154000691 @default.
- W4221072539 cites W2154730620 @default.
- W4221072539 cites W2161512142 @default.
- W4221072539 cites W2166717297 @default.
- W4221072539 cites W2179438025 @default.
- W4221072539 cites W2198743308 @default.
- W4221072539 cites W2262504552 @default.
- W4221072539 cites W2350648499 @default.
- W4221072539 cites W2481195801 @default.
- W4221072539 cites W2533355719 @default.
- W4221072539 cites W2553438302 @default.
- W4221072539 cites W2577660637 @default.
- W4221072539 cites W2588886076 @default.
- W4221072539 cites W2601477564 @default.
- W4221072539 cites W2611604995 @default.
- W4221072539 cites W2738067883 @default.
- W4221072539 cites W2765923566 @default.
- W4221072539 cites W2770867583 @default.
- W4221072539 cites W2770953820 @default.
- W4221072539 cites W2776238197 @default.
- W4221072539 cites W2778302206 @default.
- W4221072539 cites W2793331006 @default.
- W4221072539 cites W2809890412 @default.
- W4221072539 cites W2884185676 @default.
- W4221072539 cites W2884908572 @default.
- W4221072539 cites W2890213458 @default.
- W4221072539 cites W2905189499 @default.
- W4221072539 cites W2912402962 @default.
- W4221072539 cites W2967898912 @default.
- W4221072539 cites W2973052603 @default.
- W4221072539 cites W2975380634 @default.
- W4221072539 cites W2990971561 @default.
- W4221072539 cites W3008939236 @default.
- W4221072539 cites W3016420577 @default.
- W4221072539 cites W3026771322 @default.
- W4221072539 cites W3094098099 @default.
- W4221072539 cites W3127665530 @default.
- W4221072539 cites W3132793437 @default.
- W4221072539 cites W3161450387 @default.
- W4221072539 cites W3181565132 @default.
- W4221072539 cites W3188385363 @default.
- W4221072539 cites W3192313806 @default.
- W4221072539 cites W3194609671 @default.
- W4221072539 cites W3204523268 @default.
- W4221072539 cites W4211130192 @default.
- W4221072539 cites W4255178584 @default.