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• W4221072562 endingPage "114202" @default.
• W4221072562 startingPage "114202" @default.
• W4221072562 abstract "Optical biochemical assays that utilize traditional optical signaling labels, such as fluorophores and fluorescent nanoparticles, have been extensively applied in the development of optical biosensors. However, traditional optical-label-based analytical approaches require expensive and sophisticated optical instruments; thus, the application of traditional optical-label-based biochemical assays to optical biosensors in point-of-care testing (POCT) concepts that require cost-effectiveness and user-friendliness remains challenging. Retroreflection-based optical biosensing technology that utilizes micro-sized retroreflectors as an optical signaling label is being studied as a promising technological alternative to overcome the drawbacks of conventional optical-label-based biosensors. Retroreflection is an optical phenomenon whereby light rays strike a specific surface, a retroreflector, and are redirected to the light source along the inverse direction of the incident light. Biosensors that involve the retroreflection principle and retroreflector-type optical label offer distinctive advantages, such as the cost-effective simplification of optical instrument configuration, highly flexible applicability to various biochemical assays, and high analytical capability; therefore, their further applications toward the biosensing platform for POCT is highly promising. This review introduces the fundamentals of retroreflection and summarizes recent research achievements of retroreflection-based optical biosensor development from the perspective of how retroreflectors can be coupled and utilized with the optical biosensing principle as optical signal labels. The expected future applications of retroreflection-based optical biosensor technology is also discussed." @default.
• W4221072562 created "2022-04-03" @default.
• W4221072562 creator A5008071323 @default.
• W4221072562 creator A5033699178 @default.
• W4221072562 creator A5043870102 @default.
• W4221072562 creator A5069372543 @default.
• W4221072562 date "2022-07-01" @default.
• W4221072562 modified "2023-09-27" @default.
• W4221072562 title "Retroreflection-based optical biosensing: From concept to applications" @default.
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• W4221072562 doi "https://doi.org/10.1016/j.bios.2022.114202" @default.
• W4221072562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35358947" @default.
• W4221072562 hasPublicationYear "2022" @default.

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