FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221072783> ?p ?o ?g. }

• W4221072783 endingPage "717" @default.
• W4221072783 startingPage "704" @default.
• W4221072783 abstract "Heterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pivotal regulatory role as antioxidant agent, dampening the harmful effects of intracellular reactive oxidative species (ROS). Herein, we present copper-iron oxide spinel nanoparticles that exhibit a versatile and selective catalytic response to reduce GSH levels while generating ROS in a cascade reaction. We demonstrate a clear correlation between GSH depletion and apoptotic cell death in tumor cells in the presence of the copper-iron nanocatalyst. Furthermore, we also provide a novel analytical protocol, alternative to state-of-the-art commercial kits, to accurately monitoring the concentration of GSH intracellular levels in both tumor and healthy cells. We observe a selective action of the nanoparticles, with lower toxicity in healthy cell lines, whose intrinsic GSH levels are lower, and intense apoptosis in tumor cells accompanied by a fast reduction of GSH levels." @default.
• W4221072783 created "2022-04-03" @default.
• W4221072783 creator A5004499092 @default.
• W4221072783 creator A5005962311 @default.
• W4221072783 creator A5019717738 @default.
• W4221072783 creator A5065972127 @default.
• W4221072783 creator A5067353910 @default.
• W4221072783 creator A5079033791 @default.
• W4221072783 creator A5089436555 @default.
• W4221072783 date "2022-07-01" @default.
• W4221072783 modified "2023-10-14" @default.
• W4221072783 title "Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy" @default.
• W4221072783 cites W1507082667 @default.
• W4221072783 cites W1511013913 @default.
• W4221072783 cites W1558751029 @default.
• W4221072783 cites W1908647270 @default.
• W4221072783 cites W1969101934 @default.
• W4221072783 cites W1980780168 @default.
• W4221072783 cites W1983228601 @default.
• W4221072783 cites W1997815653 @default.
• W4221072783 cites W2004354097 @default.
• W4221072783 cites W2013323489 @default.
• W4221072783 cites W2019685809 @default.
• W4221072783 cites W2035838259 @default.
• W4221072783 cites W2037297543 @default.
• W4221072783 cites W2038598348 @default.
• W4221072783 cites W2048645484 @default.
• W4221072783 cites W2051533248 @default.
• W4221072783 cites W2054129051 @default.
• W4221072783 cites W2055594544 @default.
• W4221072783 cites W2058461613 @default.
• W4221072783 cites W2073803664 @default.
• W4221072783 cites W2078394930 @default.
• W4221072783 cites W2086247445 @default.
• W4221072783 cites W2097259163 @default.
• W4221072783 cites W2108189836 @default.
• W4221072783 cites W2112238783 @default.
• W4221072783 cites W2144746098 @default.
• W4221072783 cites W2149786785 @default.
• W4221072783 cites W2161431747 @default.
• W4221072783 cites W2165535625 @default.
• W4221072783 cites W2166337262 @default.
• W4221072783 cites W2221725862 @default.
• W4221072783 cites W2229268188 @default.
• W4221072783 cites W2320775668 @default.
• W4221072783 cites W2328530182 @default.
• W4221072783 cites W2331734351 @default.
• W4221072783 cites W2395626624 @default.
• W4221072783 cites W2489121689 @default.
• W4221072783 cites W2518571332 @default.
• W4221072783 cites W2527408800 @default.
• W4221072783 cites W2546723392 @default.
• W4221072783 cites W2596291542 @default.
• W4221072783 cites W2609068928 @default.
• W4221072783 cites W2609964752 @default.
• W4221072783 cites W2776167628 @default.
• W4221072783 cites W2793503277 @default.
• W4221072783 cites W2800971234 @default.
• W4221072783 cites W2809388839 @default.
• W4221072783 cites W2884605745 @default.
• W4221072783 cites W2903659409 @default.
• W4221072783 cites W2923485026 @default.
• W4221072783 cites W2939714203 @default.
• W4221072783 cites W2941208104 @default.
• W4221072783 cites W2941774798 @default.
• W4221072783 cites W2963384022 @default.
• W4221072783 cites W2985055119 @default.
• W4221072783 cites W2998215827 @default.
• W4221072783 cites W3000852122 @default.
• W4221072783 cites W3003428717 @default.
• W4221072783 cites W3005767902 @default.
• W4221072783 cites W3016702666 @default.
• W4221072783 cites W3042430795 @default.
• W4221072783 cites W3045094936 @default.
• W4221072783 cites W3046074624 @default.
• W4221072783 cites W3047971458 @default.
• W4221072783 cites W3048510814 @default.
• W4221072783 cites W3083659415 @default.
• W4221072783 cites W3083703349 @default.
• W4221072783 cites W3092136373 @default.
• W4221072783 cites W3093986491 @default.
• W4221072783 cites W3125944921 @default.
• W4221072783 cites W3126698627 @default.
• W4221072783 cites W3133463906 @default.
• W4221072783 cites W3133611223 @default.
• W4221072783 cites W3135372736 @default.
• W4221072783 cites W3152019175 @default.
• W4221072783 cites W3196742509 @default.
• W4221072783 cites W4232084141 @default.
• W4221072783 cites W4239546129 @default.
• W4221072783 doi "https://doi.org/10.1016/j.jcis.2022.03.036" @default.
• W4221072783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35316784" @default.
• W4221072783 hasPublicationYear "2022" @default.
• W4221072783 type Work @default.
• W4221072783 citedByCount "15" @default.
• W4221072783 countsByYear W42210727832022 @default.
• W4221072783 countsByYear W42210727832023 @default.
• W4221072783 crossrefType "journal-article" @default.

• next