FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221073516> ?p ?o ?g. }

• W4221073516 endingPage "1016" @default.
• W4221073516 startingPage "1008" @default.
• W4221073516 abstract "In the present meta-analysis, the efficacy and safety of perampanel (PER) for the treatment of adolescents with epilepsy were assessed.Keyword searches were performed in Embase, PubMed, Cochrane Library, Web of Science, EBSCO and CNKI from 1 January 2020 to 10 October 2020. The randomized controlled trials (RCTs) and case-control studies in which PER was compared with other Anti-seizure drugs (ASDs) and/or placebo in children with epilepsy, were considered eligible studies. Odds ratio (OR) with 95% confidence interval (95% CI) for the dichotomous outcome statistic was calculated using a fixed-effects or random-effects model.Three RCTs with a total of 372 adolescents' patients were included in this meta-analysis. Placebo was used as a control in these studies. Compared with placebo, PER showed better efficacy in median seizure frequency reduction from baseline per 28 days (OR = 2.49, 95% CI: 1.25-4.96, p = 0.009) and in responder rate (OR = 1.87, 95% CI: 1.15-3.05, p = 0.01); both were considered statistically increased in PER group. Regarding adverse effects (AEs), significant differences between PER and placebo (OR = 1.47, 95% CI: 0.92-2.41, p = 0.11) were not found, and the most common AEs of PER were dizziness (24.0%), somnolence (15.9%), headache (11.2%), nasopharyngitis (9.7%), upper respiratory tract infection (7.0%) and aggression (7.0%).Based on the results in this study, PER showed better efficacy than placebo therapy in children with epilepsy and the AEs were similar in PER group and placebo group. PER showed good efficacy and a low risk of AEs, and might be a promising medication for the treatment of pediatric epilepsy. In the future, well-designed and large-scale RCTs are necessary to validate the present findings." @default.
• W4221073516 created "2022-04-03" @default.
• W4221073516 creator A5002551693 @default.
• W4221073516 creator A5040422731 @default.
• W4221073516 creator A5044756293 @default.
• W4221073516 creator A5048760691 @default.
• W4221073516 creator A5068080767 @default.
• W4221073516 date "2022-03-18" @default.
• W4221073516 modified "2023-09-23" @default.
• W4221073516 title "Efficacy and safety of perampanel for the treatment of epilepsy in adolescents: a meta-analysis" @default.
• W4221073516 cites W1498758291 @default.
• W4221073516 cites W1584659697 @default.
• W4221073516 cites W1978795921 @default.
• W4221073516 cites W1993609519 @default.
• W4221073516 cites W2034079951 @default.
• W4221073516 cites W2039418122 @default.
• W4221073516 cites W2044758325 @default.
• W4221073516 cites W2064263928 @default.
• W4221073516 cites W2074251342 @default.
• W4221073516 cites W2089961081 @default.
• W4221073516 cites W2098923148 @default.
• W4221073516 cites W2107328434 @default.
• W4221073516 cites W2116531504 @default.
• W4221073516 cites W2117378831 @default.
• W4221073516 cites W2132687986 @default.
• W4221073516 cites W2134852288 @default.
• W4221073516 cites W2171987398 @default.
• W4221073516 cites W2180981774 @default.
• W4221073516 cites W2217932554 @default.
• W4221073516 cites W2332716921 @default.
• W4221073516 cites W2400720743 @default.
• W4221073516 cites W2516670073 @default.
• W4221073516 cites W2560633658 @default.
• W4221073516 cites W2773918607 @default.
• W4221073516 cites W2796976931 @default.
• W4221073516 cites W2905824751 @default.
• W4221073516 cites W2998501998 @default.
• W4221073516 cites W2998806808 @default.
• W4221073516 cites W4248307879 @default.
• W4221073516 doi "https://doi.org/10.1080/00207454.2022.2032045" @default.
• W4221073516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35301936" @default.
• W4221073516 hasPublicationYear "2022" @default.
• W4221073516 type Work @default.
• W4221073516 citedByCount "0" @default.
• W4221073516 crossrefType "journal-article" @default.
• W4221073516 hasAuthorship W4221073516A5002551693 @default.
• W4221073516 hasAuthorship W4221073516A5040422731 @default.
• W4221073516 hasAuthorship W4221073516A5044756293 @default.
• W4221073516 hasAuthorship W4221073516A5048760691 @default.
• W4221073516 hasAuthorship W4221073516A5068080767 @default.
• W4221073516 hasConcept C118552586 @default.
• W4221073516 hasConcept C126322002 @default.
• W4221073516 hasConcept C142724271 @default.
• W4221073516 hasConcept C156957248 @default.
• W4221073516 hasConcept C168563851 @default.
• W4221073516 hasConcept C197934379 @default.
• W4221073516 hasConcept C204787440 @default.
• W4221073516 hasConcept C27081682 @default.
• W4221073516 hasConcept C2776478404 @default.
• W4221073516 hasConcept C2778186239 @default.
• W4221073516 hasConcept C2779034229 @default.
• W4221073516 hasConcept C2780836401 @default.
• W4221073516 hasConcept C42219234 @default.
• W4221073516 hasConcept C44249647 @default.
• W4221073516 hasConcept C71924100 @default.
• W4221073516 hasConcept C95190672 @default.
• W4221073516 hasConceptScore W4221073516C118552586 @default.
• W4221073516 hasConceptScore W4221073516C126322002 @default.
• W4221073516 hasConceptScore W4221073516C142724271 @default.
• W4221073516 hasConceptScore W4221073516C156957248 @default.
• W4221073516 hasConceptScore W4221073516C168563851 @default.
• W4221073516 hasConceptScore W4221073516C197934379 @default.
• W4221073516 hasConceptScore W4221073516C204787440 @default.
• W4221073516 hasConceptScore W4221073516C27081682 @default.
• W4221073516 hasConceptScore W4221073516C2776478404 @default.
• W4221073516 hasConceptScore W4221073516C2778186239 @default.
• W4221073516 hasConceptScore W4221073516C2779034229 @default.
• W4221073516 hasConceptScore W4221073516C2780836401 @default.
• W4221073516 hasConceptScore W4221073516C42219234 @default.
• W4221073516 hasConceptScore W4221073516C44249647 @default.
• W4221073516 hasConceptScore W4221073516C71924100 @default.
• W4221073516 hasConceptScore W4221073516C95190672 @default.
• W4221073516 hasIssue "9" @default.
• W4221073516 hasLocation W42210735161 @default.
• W4221073516 hasLocation W42210735162 @default.
• W4221073516 hasOpenAccess W4221073516 @default.
• W4221073516 hasPrimaryLocation W42210735161 @default.
• W4221073516 hasRelatedWork W1731775399 @default.
• W4221073516 hasRelatedWork W2015861704 @default.
• W4221073516 hasRelatedWork W2060121528 @default.
• W4221073516 hasRelatedWork W2286371484 @default.
• W4221073516 hasRelatedWork W2318119155 @default.
• W4221073516 hasRelatedWork W2381982637 @default.
• W4221073516 hasRelatedWork W2561337999 @default.
• W4221073516 hasRelatedWork W4288033808 @default.
• W4221073516 hasRelatedWork W4291824836 @default.
• W4221073516 hasRelatedWork W4317438754 @default.
• W4221073516 hasVolume "133" @default.

• next