Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221074326> ?p ?o ?g. }
- W4221074326 endingPage "100124" @default.
- W4221074326 startingPage "100124" @default.
- W4221074326 abstract "Dissolving microneedles (DMNs) hold great popularity because of their precise drug delivery and administration portability. DMNs with different lengths could reach different depths of punctures that consequently resulted in different diffusive effects. Therefore, to clarify the effect of the length of the needles on in vivo fate of DMNs is of great significance. In this study, solid lipid nanoparticles (SLNs) were chosen as the model NC loaded in DMNs. To unambiguously determine the biological fate of the DMNs, P4 probe with aggregation caused quenching property was encapsulated in SLNs to enable the visualization of the process of the disintegration of SLNs. P4-encapsulated SLNs were loaded into DMNs with the lengths of 1200 μm, 800 μm, and 400 μm (named as DMN-1200, DMN-800, and DMN-400). By tracking the fluorescence signal distribution after skin piercing, the influence of the lengths of the needles on DMNs to the in vivo fate of the intact SLNs was explored. In the spatial dimension, intact NC loaded DMNs showed a length-dependent diffusion depth. In the temporal dimension, the diffusion rates of DMN-1200, DMN-800, and DMN-400 were similar within 24 h after insertion. It was inferred that DMNs with shorter needles would be ideal for the diseases on the superficial layer of the skin, while the ones with longer needles could be utilized in the treatment of diseases in deeper dermal and subcutaneous layers. The results of the study can act as a valuable guidance for future design and development of NC-loaded DMNs." @default.
- W4221074326 created "2022-04-03" @default.
- W4221074326 creator A5000109291 @default.
- W4221074326 creator A5001025883 @default.
- W4221074326 creator A5007837776 @default.
- W4221074326 creator A5010314867 @default.
- W4221074326 creator A5020448985 @default.
- W4221074326 creator A5044053727 @default.
- W4221074326 creator A5051337425 @default.
- W4221074326 creator A5059466925 @default.
- W4221074326 creator A5072144570 @default.
- W4221074326 creator A5089480544 @default.
- W4221074326 date "2022-06-01" @default.
- W4221074326 modified "2023-10-18" @default.
- W4221074326 title "The spatial-dimensional and temporal-dimensional fate of nanocarrier-loaded dissolving microneedles with different lengths of needles" @default.
- W4221074326 cites W1195955210 @default.
- W4221074326 cites W2001293346 @default.
- W4221074326 cites W2007539416 @default.
- W4221074326 cites W2010464045 @default.
- W4221074326 cites W2030086011 @default.
- W4221074326 cites W2080430067 @default.
- W4221074326 cites W2517604419 @default.
- W4221074326 cites W2531331071 @default.
- W4221074326 cites W2566085093 @default.
- W4221074326 cites W2795830921 @default.
- W4221074326 cites W2802152254 @default.
- W4221074326 cites W2804689657 @default.
- W4221074326 cites W2808455279 @default.
- W4221074326 cites W2896790799 @default.
- W4221074326 cites W2938837562 @default.
- W4221074326 cites W2947188873 @default.
- W4221074326 cites W2980710828 @default.
- W4221074326 cites W2981599139 @default.
- W4221074326 cites W2983937454 @default.
- W4221074326 cites W2986232994 @default.
- W4221074326 cites W3008113979 @default.
- W4221074326 cites W3013541100 @default.
- W4221074326 cites W3018583917 @default.
- W4221074326 cites W3040233988 @default.
- W4221074326 cites W3045425668 @default.
- W4221074326 cites W3048736398 @default.
- W4221074326 cites W3098487832 @default.
- W4221074326 cites W3180717858 @default.
- W4221074326 cites W3199899680 @default.
- W4221074326 doi "https://doi.org/10.1016/j.medidd.2022.100124" @default.
- W4221074326 hasPublicationYear "2022" @default.
- W4221074326 type Work @default.
- W4221074326 citedByCount "1" @default.
- W4221074326 countsByYear W42210743262023 @default.
- W4221074326 crossrefType "journal-article" @default.
- W4221074326 hasAuthorship W4221074326A5000109291 @default.
- W4221074326 hasAuthorship W4221074326A5001025883 @default.
- W4221074326 hasAuthorship W4221074326A5007837776 @default.
- W4221074326 hasAuthorship W4221074326A5010314867 @default.
- W4221074326 hasAuthorship W4221074326A5020448985 @default.
- W4221074326 hasAuthorship W4221074326A5044053727 @default.
- W4221074326 hasAuthorship W4221074326A5051337425 @default.
- W4221074326 hasAuthorship W4221074326A5059466925 @default.
- W4221074326 hasAuthorship W4221074326A5072144570 @default.
- W4221074326 hasAuthorship W4221074326A5089480544 @default.
- W4221074326 hasBestOaLocation W42210743261 @default.
- W4221074326 hasConcept C121332964 @default.
- W4221074326 hasConcept C121745418 @default.
- W4221074326 hasConcept C12554922 @default.
- W4221074326 hasConcept C136229726 @default.
- W4221074326 hasConcept C150903083 @default.
- W4221074326 hasConcept C171250308 @default.
- W4221074326 hasConcept C178790620 @default.
- W4221074326 hasConcept C185592680 @default.
- W4221074326 hasConcept C192562407 @default.
- W4221074326 hasConcept C207001950 @default.
- W4221074326 hasConcept C62520636 @default.
- W4221074326 hasConcept C69357855 @default.
- W4221074326 hasConcept C71924100 @default.
- W4221074326 hasConcept C86803240 @default.
- W4221074326 hasConcept C88380143 @default.
- W4221074326 hasConcept C91881484 @default.
- W4221074326 hasConcept C97355855 @default.
- W4221074326 hasConceptScore W4221074326C121332964 @default.
- W4221074326 hasConceptScore W4221074326C121745418 @default.
- W4221074326 hasConceptScore W4221074326C12554922 @default.
- W4221074326 hasConceptScore W4221074326C136229726 @default.
- W4221074326 hasConceptScore W4221074326C150903083 @default.
- W4221074326 hasConceptScore W4221074326C171250308 @default.
- W4221074326 hasConceptScore W4221074326C178790620 @default.
- W4221074326 hasConceptScore W4221074326C185592680 @default.
- W4221074326 hasConceptScore W4221074326C192562407 @default.
- W4221074326 hasConceptScore W4221074326C207001950 @default.
- W4221074326 hasConceptScore W4221074326C62520636 @default.
- W4221074326 hasConceptScore W4221074326C69357855 @default.
- W4221074326 hasConceptScore W4221074326C71924100 @default.
- W4221074326 hasConceptScore W4221074326C86803240 @default.
- W4221074326 hasConceptScore W4221074326C88380143 @default.
- W4221074326 hasConceptScore W4221074326C91881484 @default.
- W4221074326 hasConceptScore W4221074326C97355855 @default.
- W4221074326 hasFunder F4320321001 @default.
- W4221074326 hasFunder F4320336405 @default.
- W4221074326 hasLocation W42210743261 @default.