FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221075040> ?p ?o ?g. }

• W4221075040 abstract "Circulating cell-free DNA (cfDNA) can be used to characterize tumor genomes through next-generation sequencing (NGS)-based approaches. We aim to identify novel genetic alterations associated with drug resistance in lung cancer and colorectal cancer patients who were treated with EGFR-targeted therapy and cytotoxic chemotherapy through whole exome sequencing (WES) of cfDNA. A cohort of 18 lung cancer patients was treated with EGFR TKI or cytotoxic chemotherapy, and a cohort of 37 colorectal cancer patients was treated with EGFR monoclonal antibody or cytotoxic chemotherapy alone. Serum samples were drawn before and after development of drug resistance, and the genetic mutational profile was analyzed with WES data. For 110 paired cfDNA and matched germline DNA WES samples, mean coverage of 138x (range, 52-208.4x) and 47x (range, 30.5-125.1x) was achieved, respectively. After excluding synonymous variants, mutants identified in more than two patients at the time of acquired resistance were selected. Seven genes in lung cancer and 16 genes in colorectal cancer were found, namely, APC, TP53, KRAS, SMAD4, and EGFR. In addition, the GPR155 I357S mutation in lung cancer and ADAMTS20 S1597P and TTN R7415H mutations in colorectal cancer were frequently detected at the time of acquired resistance, indicating that these mutations have an important function in acquired resistance to chemotherapy. Our data suggest that novel genetic variants associated with drug resistance can be identified using cfDNA WES. Further validation is necessary, but these candidate genes are promising therapeutic targets for overcoming drug resistance in lung cancer and colorectal cancer." @default.
• W4221075040 created "2022-04-03" @default.
• W4221075040 creator A5000632236 @default.
• W4221075040 creator A5012978828 @default.
• W4221075040 creator A5021336715 @default.
• W4221075040 creator A5064663707 @default.
• W4221075040 creator A5068895221 @default.
• W4221075040 creator A5070638161 @default.
• W4221075040 creator A5077563153 @default.
• W4221075040 creator A5081997635 @default.
• W4221075040 creator A5082389963 @default.
• W4221075040 creator A5084355267 @default.
• W4221075040 creator A5085331819 @default.
• W4221075040 date "2022-03-24" @default.
• W4221075040 modified "2023-10-05" @default.
• W4221075040 title "Genetic Characteristics Associated With Drug Resistance in Lung Cancer and Colorectal Cancer Using Whole Exome Sequencing of Cell-Free DNA" @default.
• W4221075040 cites W1963853602 @default.
• W4221075040 cites W1983466841 @default.
• W4221075040 cites W1989814102 @default.
• W4221075040 cites W2019607817 @default.
• W4221075040 cites W2028132950 @default.
• W4221075040 cites W2103441770 @default.
• W4221075040 cites W2119180969 @default.
• W4221075040 cites W2119263822 @default.
• W4221075040 cites W2128059540 @default.
• W4221075040 cites W2140575188 @default.
• W4221075040 cites W2146036559 @default.
• W4221075040 cites W2152745352 @default.
• W4221075040 cites W2171237493 @default.
• W4221075040 cites W2276335691 @default.
• W4221075040 cites W2291298003 @default.
• W4221075040 cites W2352491315 @default.
• W4221075040 cites W2405513305 @default.
• W4221075040 cites W2470575266 @default.
• W4221075040 cites W2561259078 @default.
• W4221075040 cites W2587440434 @default.
• W4221075040 cites W2606050648 @default.
• W4221075040 cites W2674724928 @default.
• W4221075040 cites W2683235845 @default.
• W4221075040 cites W2744683676 @default.
• W4221075040 cites W2749372468 @default.
• W4221075040 cites W2753284985 @default.
• W4221075040 cites W2764191636 @default.
• W4221075040 cites W2765435739 @default.
• W4221075040 cites W2767034994 @default.
• W4221075040 cites W2768468176 @default.
• W4221075040 cites W2770980874 @default.
• W4221075040 cites W2773284654 @default.
• W4221075040 cites W2774290425 @default.
• W4221075040 cites W2774773003 @default.
• W4221075040 cites W2782675598 @default.
• W4221075040 cites W2795073885 @default.
• W4221075040 cites W2795993993 @default.
• W4221075040 cites W2808484886 @default.
• W4221075040 cites W2867868648 @default.
• W4221075040 cites W2885111416 @default.
• W4221075040 cites W2891141728 @default.
• W4221075040 cites W2920848372 @default.
• W4221075040 cites W2941018206 @default.
• W4221075040 cites W2945858728 @default.
• W4221075040 cites W2963046727 @default.
• W4221075040 cites W2971526774 @default.
• W4221075040 cites W2972422665 @default.
• W4221075040 cites W2981966630 @default.
• W4221075040 cites W2982364317 @default.
• W4221075040 cites W2984908501 @default.
• W4221075040 cites W2988962478 @default.
• W4221075040 cites W2990871782 @default.
• W4221075040 cites W2993380934 @default.
• W4221075040 cites W2995345513 @default.
• W4221075040 cites W2997084844 @default.
• W4221075040 cites W3001961106 @default.
• W4221075040 cites W3009766806 @default.
• W4221075040 cites W3012074589 @default.
• W4221075040 cites W3033787835 @default.
• W4221075040 cites W3048241929 @default.
• W4221075040 cites W3126060141 @default.
• W4221075040 cites W3137719687 @default.
• W4221075040 cites W3159664125 @default.
• W4221075040 cites W3170015715 @default.
• W4221075040 cites W3178280348 @default.
• W4221075040 cites W4234746319 @default.
• W4221075040 cites W4376848401 @default.
• W4221075040 doi "https://doi.org/10.3389/fonc.2022.843561" @default.
• W4221075040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402275" @default.
• W4221075040 hasPublicationYear "2022" @default.
• W4221075040 type Work @default.
• W4221075040 citedByCount "3" @default.
• W4221075040 countsByYear W42210750402022 @default.
• W4221075040 countsByYear W42210750402023 @default.
• W4221075040 crossrefType "journal-article" @default.
• W4221075040 hasAuthorship W4221075040A5000632236 @default.
• W4221075040 hasAuthorship W4221075040A5012978828 @default.
• W4221075040 hasAuthorship W4221075040A5021336715 @default.
• W4221075040 hasAuthorship W4221075040A5064663707 @default.
• W4221075040 hasAuthorship W4221075040A5068895221 @default.
• W4221075040 hasAuthorship W4221075040A5070638161 @default.
• W4221075040 hasAuthorship W4221075040A5077563153 @default.
• W4221075040 hasAuthorship W4221075040A5081997635 @default.
• W4221075040 hasAuthorship W4221075040A5082389963 @default.

• next