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- W4221075436 abstract "Abstract During the late stages of the HIV-1 lifecycle, immature virions are produced by the concerted activity of Gag polyproteins, primarily mediated by the capsid (CA) and spacer peptide 1 (SP1) domains, which assemble into a spherical lattice, package viral genomic RNA, and deform the plasma membrane. Recently, inositol hexakisphosphate (IP6) has been identified as an essential assembly cofactor that efficiently produces both immature virions in vivo and immature virus-like particles in vitro . To date, however, several distinct mechanistic roles for IP6 have been proposed on the basis of independent functional, structural, and kinetic studies. In this work, we investigate the molecular influence of IP6 on the structural outcomes and dynamics of CA/SP1 assembly using coarse-grained (CG) molecular dynamics (MD) simulations and free energy calculations. Here, we derive a bottom-up, low-resolution, and implicit-solvent CG model of CA/SP1 and IP6, and simulate their assembly under conditions that emulate both in vitro and in vivo systems. Our analysis identifies IP6 as an assembly accelerant that promotes curvature generation and fissure-like defects throughout the lattice. Our findings suggest that IP6 induces kinetically-trapped immature morphologies, which may be physiologically important for later stages of viral morphogenesis and potentially useful for virus-like particle technologies." @default.
- W4221075436 created "2022-04-03" @default.
- W4221075436 creator A5001612107 @default.
- W4221075436 creator A5004172217 @default.
- W4221075436 creator A5070557615 @default.
- W4221075436 creator A5075789940 @default.
- W4221075436 date "2022-03-29" @default.
- W4221075436 modified "2023-10-15" @default.
- W4221075436 title "Inositol hexakisphosphate (IP6) accelerates immature HIV-1 Gag protein assembly towards kinetically-trapped morphologies" @default.
- W4221075436 cites W1031578623 @default.
- W4221075436 cites W1925325850 @default.
- W4221075436 cites W1969819429 @default.
- W4221075436 cites W1983749753 @default.
- W4221075436 cites W1986342431 @default.
- W4221075436 cites W1987025068 @default.
- W4221075436 cites W1988158937 @default.
- W4221075436 cites W1990784474 @default.
- W4221075436 cites W1994410560 @default.
- W4221075436 cites W2003949305 @default.
- W4221075436 cites W2004509570 @default.
- W4221075436 cites W2013652077 @default.
- W4221075436 cites W2016033647 @default.
- W4221075436 cites W2017686863 @default.
- W4221075436 cites W2019266755 @default.
- W4221075436 cites W2019465613 @default.
- W4221075436 cites W2021064626 @default.
- W4221075436 cites W2025244778 @default.
- W4221075436 cites W2025472947 @default.
- W4221075436 cites W2025625972 @default.
- W4221075436 cites W2027300565 @default.
- W4221075436 cites W2029667189 @default.
- W4221075436 cites W2034307675 @default.
- W4221075436 cites W2035266068 @default.
- W4221075436 cites W2036196992 @default.
- W4221075436 cites W2041321679 @default.
- W4221075436 cites W2043701535 @default.
- W4221075436 cites W2048806742 @default.
- W4221075436 cites W2049390938 @default.
- W4221075436 cites W2056617023 @default.
- W4221075436 cites W2057712924 @default.
- W4221075436 cites W2057806291 @default.
- W4221075436 cites W2058653824 @default.
- W4221075436 cites W2060174126 @default.
- W4221075436 cites W2062334646 @default.
- W4221075436 cites W2066053818 @default.
- W4221075436 cites W2072984130 @default.
- W4221075436 cites W2086634221 @default.
- W4221075436 cites W2087978946 @default.
- W4221075436 cites W2093904805 @default.
- W4221075436 cites W2107066237 @default.
- W4221075436 cites W2107120241 @default.
- W4221075436 cites W2112727291 @default.
- W4221075436 cites W2115382947 @default.
- W4221075436 cites W2117091532 @default.
- W4221075436 cites W2117867057 @default.
- W4221075436 cites W2118223132 @default.
- W4221075436 cites W2121563903 @default.
- W4221075436 cites W2128780965 @default.
- W4221075436 cites W2135648640 @default.
- W4221075436 cites W2137253809 @default.
- W4221075436 cites W2137919235 @default.
- W4221075436 cites W2144831923 @default.
- W4221075436 cites W2145652748 @default.
- W4221075436 cites W2146411229 @default.
- W4221075436 cites W2147792469 @default.
- W4221075436 cites W2152539875 @default.
- W4221075436 cites W2162452471 @default.
- W4221075436 cites W2163809370 @default.
- W4221075436 cites W2167615773 @default.
- W4221075436 cites W2191347095 @default.
- W4221075436 cites W2316259871 @default.
- W4221075436 cites W2333137500 @default.
- W4221075436 cites W2334437992 @default.
- W4221075436 cites W2466725324 @default.
- W4221075436 cites W2470140135 @default.
- W4221075436 cites W2734451627 @default.
- W4221075436 cites W2768954818 @default.
- W4221075436 cites W2793632108 @default.
- W4221075436 cites W2808260075 @default.
- W4221075436 cites W2886259097 @default.
- W4221075436 cites W2891492340 @default.
- W4221075436 cites W2923188602 @default.
- W4221075436 cites W2926355223 @default.
- W4221075436 cites W2950776490 @default.
- W4221075436 cites W2951605984 @default.
- W4221075436 cites W2952327922 @default.
- W4221075436 cites W2955761623 @default.
- W4221075436 cites W2992616830 @default.
- W4221075436 cites W2994798248 @default.
- W4221075436 cites W3000717531 @default.
- W4221075436 cites W3041039652 @default.
- W4221075436 cites W3043992826 @default.
- W4221075436 cites W3045584868 @default.
- W4221075436 cites W3061695929 @default.
- W4221075436 cites W3093404578 @default.
- W4221075436 cites W3106674684 @default.
- W4221075436 cites W3120649156 @default.
- W4221075436 cites W3165609530 @default.
- W4221075436 cites W4206390074 @default.
- W4221075436 cites W4246043393 @default.