FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221077830> ?p ?o ?g. }

• W4221077830 abstract "Patients with hepatic cirrhosis are more susceptible to Clostridioides difficile infection (CDI) and colonization with Clostridioides difficile (C. difficile). Asymptomatic C. difficile colonization is thought to predispose to subsequent CDI. However, the dynamic gut microbiota changes remain unclear. In this study, we used 16S rRNA gene sequencing to longitudinally monitor alterations in the intestinal microbiota of 22 hepatic cirrhosis patients with toxigenic C. difficile colonization at admission (pre-CDI) and developed CDI during hospitalization, subdivided into pre-CDI and CDI. 21 hospitalized cirrhotic patients without C. difficile colonization served as controls (HC). Compared with HC, pre-CDI and CDI samples had significantly decreased microbial richness and diversity, a significantly higher relative abundance of opportunistic pathogen Enterococcus, and a lower relative abundance of beneficial symbionts, such as Faecalibacterium, Dorea, and Roseburia. Three biomarkers showed high accuracy for distinguishing pre-CDI samples from HC with an area under the curve (AUC) up to 0.81. In conclusion, our study explored the changes of the gut microbiome before and after CDI. The gut microbial richness as well as diversity in CDI patients were notably reduced, relative to controls. Imbalance of the intestinal flora may be related to the risk for development of CDI. Identifying key members of the gut microbiota and illustrating their roles and mechanisms of action in CDI development are important avenues for future research." @default.
• W4221077830 created "2022-04-03" @default.
• W4221077830 creator A5007535547 @default.
• W4221077830 creator A5029913879 @default.
• W4221077830 creator A5049425878 @default.
• W4221077830 creator A5055916244 @default.
• W4221077830 creator A5056990147 @default.
• W4221077830 creator A5057422995 @default.
• W4221077830 creator A5064585529 @default.
• W4221077830 creator A5081141794 @default.
• W4221077830 date "2022-04-01" @default.
• W4221077830 modified "2023-09-27" @default.
• W4221077830 title "Disordered Intestinal Microbial Communities During Clostridioides difficile Colonization and Subsequent Infection of Hepatic Cirrhosis Patients in a Tertiary Care Hospital in China" @default.
• W4221077830 cites W1647973912 @default.
• W4221077830 cites W1922610231 @default.
• W4221077830 cites W1979012796 @default.
• W4221077830 cites W1993830991 @default.
• W4221077830 cites W2006446060 @default.
• W4221077830 cites W2024372253 @default.
• W4221077830 cites W2025589766 @default.
• W4221077830 cites W2033052827 @default.
• W4221077830 cites W2034546710 @default.
• W4221077830 cites W2048093113 @default.
• W4221077830 cites W2082559230 @default.
• W4221077830 cites W208644631 @default.
• W4221077830 cites W2088842237 @default.
• W4221077830 cites W2096436144 @default.
• W4221077830 cites W2104491546 @default.
• W4221077830 cites W2112968037 @default.
• W4221077830 cites W2127424257 @default.
• W4221077830 cites W2133856765 @default.
• W4221077830 cites W2145988176 @default.
• W4221077830 cites W2148425673 @default.
• W4221077830 cites W2158145640 @default.
• W4221077830 cites W2162088497 @default.
• W4221077830 cites W2343435145 @default.
• W4221077830 cites W2507523231 @default.
• W4221077830 cites W2570602940 @default.
• W4221077830 cites W2756891381 @default.
• W4221077830 cites W2796760994 @default.
• W4221077830 cites W2898199093 @default.
• W4221077830 cites W2911396917 @default.
• W4221077830 cites W2911858059 @default.
• W4221077830 cites W2915585851 @default.
• W4221077830 cites W3015060289 @default.
• W4221077830 cites W3021533321 @default.
• W4221077830 cites W3028215187 @default.
• W4221077830 cites W3029249211 @default.
• W4221077830 cites W3042330063 @default.
• W4221077830 cites W3088770755 @default.
• W4221077830 cites W3125074120 @default.
• W4221077830 cites W3154100391 @default.
• W4221077830 cites W3158607664 @default.
• W4221077830 cites W3167912797 @default.
• W4221077830 cites W3197800477 @default.
• W4221077830 cites W4210377299 @default.
• W4221077830 cites W4220826779 @default.
• W4221077830 doi "https://doi.org/10.3389/fcimb.2022.825189" @default.
• W4221077830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35433508" @default.
• W4221077830 hasPublicationYear "2022" @default.
• W4221077830 type Work @default.
• W4221077830 citedByCount "0" @default.
• W4221077830 crossrefType "journal-article" @default.
• W4221077830 hasAuthorship W4221077830A5007535547 @default.
• W4221077830 hasAuthorship W4221077830A5029913879 @default.
• W4221077830 hasAuthorship W4221077830A5049425878 @default.
• W4221077830 hasAuthorship W4221077830A5055916244 @default.
• W4221077830 hasAuthorship W4221077830A5056990147 @default.
• W4221077830 hasAuthorship W4221077830A5057422995 @default.
• W4221077830 hasAuthorship W4221077830A5064585529 @default.
• W4221077830 hasAuthorship W4221077830A5081141794 @default.
• W4221077830 hasBestOaLocation W42210778301 @default.
• W4221077830 hasConcept C126322002 @default.
• W4221077830 hasConcept C143121216 @default.
• W4221077830 hasConcept C189506811 @default.
• W4221077830 hasConcept C203014093 @default.
• W4221077830 hasConcept C2776927270 @default.
• W4221077830 hasConcept C2777165150 @default.
• W4221077830 hasConcept C2777214474 @default.
• W4221077830 hasConcept C2910067853 @default.
• W4221077830 hasConcept C539455810 @default.
• W4221077830 hasConcept C60644358 @default.
• W4221077830 hasConcept C71924100 @default.
• W4221077830 hasConcept C86803240 @default.
• W4221077830 hasConcept C89423630 @default.
• W4221077830 hasConcept C90924648 @default.
• W4221077830 hasConceptScore W4221077830C126322002 @default.
• W4221077830 hasConceptScore W4221077830C143121216 @default.
• W4221077830 hasConceptScore W4221077830C189506811 @default.
• W4221077830 hasConceptScore W4221077830C203014093 @default.
• W4221077830 hasConceptScore W4221077830C2776927270 @default.
• W4221077830 hasConceptScore W4221077830C2777165150 @default.
• W4221077830 hasConceptScore W4221077830C2777214474 @default.
• W4221077830 hasConceptScore W4221077830C2910067853 @default.
• W4221077830 hasConceptScore W4221077830C539455810 @default.
• W4221077830 hasConceptScore W4221077830C60644358 @default.
• W4221077830 hasConceptScore W4221077830C71924100 @default.
• W4221077830 hasConceptScore W4221077830C86803240 @default.
• W4221077830 hasConceptScore W4221077830C89423630 @default.
• W4221077830 hasConceptScore W4221077830C90924648 @default.

• next