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- W4221078906 endingPage "362" @default.
- W4221078906 startingPage "362" @default.
- W4221078906 abstract "Bloodstream infections (BSIs) in critically ill patients are associated with significant mortality. For patients with septic shock, antibiotics should be administered within the hour. Probabilistic treatment should be targeted to the most likely pathogens, considering the source and risk factors for bacterial resistance including local epidemiology. Source control is a critical component of the management. Sending blood cultures (BCs) and other specimens before antibiotic administration, without delaying them, is key to microbiological diagnosis and subsequent opportunities for antimicrobial stewardship. Molecular rapid diagnostic testing may provide faster identification of pathogens and specific resistance patterns from the initial positive BC. Results allow for antibiotic optimisation, targeting the causative pathogen with escalation or de-escalation as required. Through this clinically oriented narrative review, we provide expert commentary for empirical and targeted antibiotic choice, including a review of the evidence and recommendations for the treatments of extended-spectrum β-lactamase-producing, AmpC-hyperproducing and carbapenem-resistant Enterobacterales; carbapenem-resistant Acinetobacter baumannii; and Staphylococcus aureus. In order to improve clinical outcomes, dosing recommendations and pharmacokinetics/pharmacodynamics specific to ICU patients must be followed, alongside therapeutic drug monitoring." @default.
- W4221078906 created "2022-04-03" @default.
- W4221078906 creator A5012692234 @default.
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- W4221078906 creator A5066789024 @default.
- W4221078906 creator A5074263021 @default.
- W4221078906 creator A5075715397 @default.
- W4221078906 date "2022-03-08" @default.
- W4221078906 modified "2023-10-17" @default.
- W4221078906 title "Use of Antimicrobials for Bloodstream Infections in the Intensive Care Unit, a Clinically Oriented Review" @default.
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- W4221078906 doi "https://doi.org/10.3390/antibiotics11030362" @default.
- W4221078906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35326825" @default.
- W4221078906 hasPublicationYear "2022" @default.
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