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• W4221079427 endingPage "154578" @default.
• W4221079427 startingPage "154578" @default.
• W4221079427 abstract "Mammographic density (MD), expressed as percentage of fibroglandular breast tissue, is an important risk factor for breast cancer. Our objective is to investigate the relationship between MD and residential proximity to pollutant industries in premenopausal Spanish women.A cross-sectional study was carried out in a sample of 1225 women extracted from the DDM-Madrid study. Multiple linear regression models were used to assess the association of MD percentage (and their 95% confidence intervals (95%CIs)) and proximity (between 1 km and 3 km) to industries included in the European Pollutant Release and Transfer Register.Although no association was found between MD and distance to all industries as a whole, several industrial sectors showed significant association for some distances: surface treatment of metals and plastic (β = 4.98, 95%CI = (0.85; 9.12) at ≤1.5 km, and β = 3.00, 95%CI = (0.26; 5.73) at ≤2.5 km), organic chemical industry (β = 6.73, 95%CI = (0.50; 12.97) at ≤1.5 km), pharmaceutical products (β = 4.14, 95%CI = (0.58; 7.70) at ≤2 km; β = 3.55, 95%CI = (0.49; 6.60) at ≤2.5 km; and β = 3.11, 95%CI = (0.20; 6.01) at ≤3 km), and urban waste-water treatment plants (β = 8.06, 95%CI = (0.82; 15.30) at ≤1 km; β = 5.28; 95%CI = (0.49; 10.06) at ≤1.5 km; β = 4.30, 95%CI = (0.03; 8.57) at ≤2 km; β = 5.26, 95%CI = (1.83; 8.68) at ≤2.5 km; and β = 3.19, 95%CI = (0.46; 5.92) at ≤3 km). Moreover, significant increased MD was observed in women close to industries releasing specific pollutants: ammonia (β = 4.55, 95%CI = (0.26; 8.83) at ≤1.5 km; and β = 3.81, 95%CI = (0.49; 7.14) at ≤2 km), dichloromethane (β = 3.86, 95%CI = (0.00; 7.71) at ≤2 km), ethylbenzene (β = 8.96, 95%CI = (0.57; 17.35) at ≤3 km), and phenols (β = 2.60, 95%CI = (0.21; 5.00) at ≤2.5 km).Our results suggest no statistically significant relationship between MD and proximity to industries as a whole, although we detected associations with various industrial sectors and some specific pollutants, which suggests that MD could have a mediating role in breast carcinogenesis." @default.
• W4221079427 created "2022-04-03" @default.
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• W4221079427 date "2022-07-01" @default.
• W4221079427 modified "2023-10-18" @default.
• W4221079427 title "Residential proximity to industrial pollution and mammographic density" @default.
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• W4221079427 doi "https://doi.org/10.1016/j.scitotenv.2022.154578" @default.
• W4221079427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35304152" @default.
• W4221079427 hasPublicationYear "2022" @default.
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