Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221083448> ?p ?o ?g. }
- W4221083448 endingPage "221" @default.
- W4221083448 startingPage "198" @default.
- W4221083448 abstract "Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies. While many rat and mouse models of T2DM exist, the phenotyping of DPN has been challenging with inconsistencies across laboratories. To better characterize DPN in rodents, a consensus guideline was published in 2014 to accelerate the translation of preclinical findings. Here we review DPN phenotyping in rat models of T2DM against the ‘Neurodiab’ criteria to identify uptake of the guidelines and discuss how DPN phenotypes differ between models and according to diabetes duration and sex. A search of PubMed, Scopus and Web of Science databases identified 125 studies, categorised as either diet and/or chemically induced models or transgenic/spontaneous models of T2DM. The use of diet and chemically induced T2DM models has exceeded that of transgenic models in recent years, and the introduction of the Neurodiab guidelines has not appreciably increased the number of studies assessing all key DPN endpoints. Combined high-fat diet and low dose streptozotocin rat models are the most frequently used and well characterised. Overall, we recommend adherence to Neurodiab guidelines for creating better animal models of DPN to accelerate translation and drug development." @default.
- W4221083448 created "2022-04-03" @default.
- W4221083448 creator A5003886260 @default.
- W4221083448 creator A5028990753 @default.
- W4221083448 creator A5030791967 @default.
- W4221083448 creator A5045490283 @default.
- W4221083448 creator A5072857405 @default.
- W4221083448 date "2022-03-31" @default.
- W4221083448 modified "2023-10-09" @default.
- W4221083448 title "Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions" @default.
- W4221083448 cites W1146891662 @default.
- W4221083448 cites W1494247371 @default.
- W4221083448 cites W1557448173 @default.
- W4221083448 cites W1611811727 @default.
- W4221083448 cites W1969604629 @default.
- W4221083448 cites W1972444084 @default.
- W4221083448 cites W1972540169 @default.
- W4221083448 cites W1975943627 @default.
- W4221083448 cites W1980365490 @default.
- W4221083448 cites W1982371325 @default.
- W4221083448 cites W1985079741 @default.
- W4221083448 cites W1991667225 @default.
- W4221083448 cites W1993480354 @default.
- W4221083448 cites W1995651519 @default.
- W4221083448 cites W2004092276 @default.
- W4221083448 cites W2007241004 @default.
- W4221083448 cites W2013389100 @default.
- W4221083448 cites W2014007136 @default.
- W4221083448 cites W2020006845 @default.
- W4221083448 cites W2020712539 @default.
- W4221083448 cites W2023217835 @default.
- W4221083448 cites W2024391792 @default.
- W4221083448 cites W2024536627 @default.
- W4221083448 cites W2026460894 @default.
- W4221083448 cites W2026734722 @default.
- W4221083448 cites W2030053126 @default.
- W4221083448 cites W2034185445 @default.
- W4221083448 cites W2034349817 @default.
- W4221083448 cites W2037202261 @default.
- W4221083448 cites W2039770754 @default.
- W4221083448 cites W2040580317 @default.
- W4221083448 cites W2046290896 @default.
- W4221083448 cites W2051129372 @default.
- W4221083448 cites W2065218028 @default.
- W4221083448 cites W2065488327 @default.
- W4221083448 cites W2072764168 @default.
- W4221083448 cites W2077883814 @default.
- W4221083448 cites W2078011416 @default.
- W4221083448 cites W2078112289 @default.
- W4221083448 cites W2078256040 @default.
- W4221083448 cites W2081860702 @default.
- W4221083448 cites W2082335785 @default.
- W4221083448 cites W2088889332 @default.
- W4221083448 cites W2091103694 @default.
- W4221083448 cites W2091609068 @default.
- W4221083448 cites W2091926443 @default.
- W4221083448 cites W2096877115 @default.
- W4221083448 cites W2098628484 @default.
- W4221083448 cites W2099568596 @default.
- W4221083448 cites W2102611308 @default.
- W4221083448 cites W2110244140 @default.
- W4221083448 cites W2113880168 @default.
- W4221083448 cites W2115117362 @default.
- W4221083448 cites W2120184033 @default.
- W4221083448 cites W2125494078 @default.
- W4221083448 cites W2130698995 @default.
- W4221083448 cites W2132989433 @default.
- W4221083448 cites W2137347183 @default.
- W4221083448 cites W2140290619 @default.
- W4221083448 cites W2141438284 @default.
- W4221083448 cites W2144138736 @default.
- W4221083448 cites W2153804110 @default.
- W4221083448 cites W2154210264 @default.
- W4221083448 cites W2154935464 @default.
- W4221083448 cites W2155248498 @default.
- W4221083448 cites W2157684339 @default.
- W4221083448 cites W2157887773 @default.
- W4221083448 cites W2172201406 @default.
- W4221083448 cites W2195680597 @default.
- W4221083448 cites W2206031061 @default.
- W4221083448 cites W2215477830 @default.
- W4221083448 cites W2231275896 @default.
- W4221083448 cites W2257505506 @default.
- W4221083448 cites W2273843302 @default.
- W4221083448 cites W2288924047 @default.
- W4221083448 cites W2319030457 @default.
- W4221083448 cites W2338186585 @default.
- W4221083448 cites W2340554437 @default.
- W4221083448 cites W2345878622 @default.
- W4221083448 cites W2412133250 @default.
- W4221083448 cites W2412552459 @default.
- W4221083448 cites W2465504892 @default.
- W4221083448 cites W2469169435 @default.
- W4221083448 cites W2472126301 @default.
- W4221083448 cites W2482140056 @default.
- W4221083448 cites W2507204478 @default.
- W4221083448 cites W2526968232 @default.
- W4221083448 cites W2527204490 @default.