FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221084700> ?p ?o ?g. }

• W4221084700 endingPage "241" @default.
• W4221084700 startingPage "228" @default.
• W4221084700 abstract "Insufficient osseointegration and biofilm-associated bacterial infection are important challenges for clinical application of titanium (Ti)-based implants. Here, we constructed mesoporous polydopamine (MPDA) nanoparticles (NPs) loaded with luteolin (LUT, a quorum sensing inhibitor), which were further coated with the shell of calcium phosphate (CaP) to construct MPDA-LUT@CaP nanosystem. Then, MPDA-LUT@CaP NPs were immobilized on the surface of Ti implants. Under acidic environment of bacterial biofilm-infection, the CaP shell of MPDA-LUT@CaP NPs was rapidly degraded and released LUT, Ca2+ and PO43- from the surface of Ti implant. LUT could effectively inhibit and disperse biofilm. Furthermore, under near-infrared irradiation (NIR), the thermotherapy induced by the photothermal conversion effect of MPDA destroyed the integrity of the bacterial membrane, and synergistically led to protein leakage and a decrease in ATP levels. Combined with photothermal therapy (PTT) and quorum-sensing-inhibition strategy, the surface-functionalized Ti substrate had an antibacterial rate of over 95.59% against Staphylococcus aureus and the elimination rate of the formed biofilm was as high as 90.3%, so as to achieve low temperature and efficient treatment of bacterial biofilm infection. More importantly, the modified Ti implant accelerated the growth of cell and the healing process of bone tissue due to the released Ca2+ and PO43-. In summary, this work combined PTT with quorum-sensing-inhibition strategy provides a new idea for surface functionalization of implant for achieving effective antibacterial and osseointegration capabilities." @default.
• W4221084700 created "2022-04-03" @default.
• W4221084700 creator A5013093583 @default.
• W4221084700 creator A5014913742 @default.
• W4221084700 creator A5017737355 @default.
• W4221084700 creator A5023252191 @default.
• W4221084700 creator A5027890066 @default.
• W4221084700 creator A5027937292 @default.
• W4221084700 creator A5068459889 @default.
• W4221084700 creator A5076139079 @default.
• W4221084700 creator A5087088786 @default.
• W4221084700 date "2022-12-01" @default.
• W4221084700 modified "2023-10-16" @default.
• W4221084700 title "Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection" @default.
• W4221084700 cites W1982414211 @default.
• W4221084700 cites W1989845364 @default.
• W4221084700 cites W1992774222 @default.
• W4221084700 cites W2010643522 @default.
• W4221084700 cites W2033197601 @default.
• W4221084700 cites W2095670129 @default.
• W4221084700 cites W2238405327 @default.
• W4221084700 cites W2316245666 @default.
• W4221084700 cites W2480010979 @default.
• W4221084700 cites W2511941815 @default.
• W4221084700 cites W2559250668 @default.
• W4221084700 cites W2563488620 @default.
• W4221084700 cites W2600243824 @default.
• W4221084700 cites W2605976672 @default.
• W4221084700 cites W2740875536 @default.
• W4221084700 cites W2796394769 @default.
• W4221084700 cites W2809266196 @default.
• W4221084700 cites W2888195855 @default.
• W4221084700 cites W2890889375 @default.
• W4221084700 cites W2895822791 @default.
• W4221084700 cites W2896255065 @default.
• W4221084700 cites W2899901347 @default.
• W4221084700 cites W2900796598 @default.
• W4221084700 cites W2901341767 @default.
• W4221084700 cites W2907337669 @default.
• W4221084700 cites W2911724766 @default.
• W4221084700 cites W2912387238 @default.
• W4221084700 cites W2920137369 @default.
• W4221084700 cites W2951028627 @default.
• W4221084700 cites W2960571250 @default.
• W4221084700 cites W2967253146 @default.
• W4221084700 cites W2968218512 @default.
• W4221084700 cites W2969976828 @default.
• W4221084700 cites W2972008018 @default.
• W4221084700 cites W2980154216 @default.
• W4221084700 cites W2982596542 @default.
• W4221084700 cites W2997751167 @default.
• W4221084700 cites W3006762758 @default.
• W4221084700 cites W3012103585 @default.
• W4221084700 cites W3014633359 @default.
• W4221084700 cites W3035441928 @default.
• W4221084700 cites W3037214868 @default.
• W4221084700 cites W3096365036 @default.
• W4221084700 cites W3103700276 @default.
• W4221084700 cites W3109482165 @default.
• W4221084700 cites W3110838600 @default.
• W4221084700 cites W3113579386 @default.
• W4221084700 cites W3134245875 @default.
• W4221084700 cites W3164857871 @default.
• W4221084700 cites W3172879765 @default.
• W4221084700 cites W3199258779 @default.
• W4221084700 cites W3210351092 @default.
• W4221084700 cites W4250821936 @default.
• W4221084700 doi "https://doi.org/10.1016/j.bioactmat.2022.03.011" @default.
• W4221084700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35387171" @default.
• W4221084700 hasPublicationYear "2022" @default.
• W4221084700 type Work @default.
• W4221084700 citedByCount "33" @default.
• W4221084700 countsByYear W42210847002022 @default.
• W4221084700 countsByYear W42210847002023 @default.
• W4221084700 crossrefType "journal-article" @default.
• W4221084700 hasAuthorship W4221084700A5013093583 @default.
• W4221084700 hasAuthorship W4221084700A5014913742 @default.
• W4221084700 hasAuthorship W4221084700A5017737355 @default.
• W4221084700 hasAuthorship W4221084700A5023252191 @default.
• W4221084700 hasAuthorship W4221084700A5027890066 @default.
• W4221084700 hasAuthorship W4221084700A5027937292 @default.
• W4221084700 hasAuthorship W4221084700A5068459889 @default.
• W4221084700 hasAuthorship W4221084700A5076139079 @default.
• W4221084700 hasAuthorship W4221084700A5087088786 @default.
• W4221084700 hasBestOaLocation W42210847002 @default.
• W4221084700 hasConcept C101414908 @default.
• W4221084700 hasConcept C115537861 @default.
• W4221084700 hasConcept C118687296 @default.
• W4221084700 hasConcept C141071460 @default.
• W4221084700 hasConcept C147789679 @default.
• W4221084700 hasConcept C171250308 @default.
• W4221084700 hasConcept C182606246 @default.
• W4221084700 hasConcept C185592680 @default.
• W4221084700 hasConcept C188027245 @default.
• W4221084700 hasConcept C191897082 @default.
• W4221084700 hasConcept C192562407 @default.
• W4221084700 hasConcept C2780077769 @default.
• W4221084700 hasConcept C2781411149 @default.

• next