Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221090669> ?p ?o ?g. }
- W4221090669 endingPage "424" @default.
- W4221090669 startingPage "424" @default.
- W4221090669 abstract "Tackling neurodegeneration and neuroinflammation is particularly challenging due to the complexity of central nervous system (CNS) disorders, as well as the limited drug accessibility to the brain. The activation of tropomyosin-related kinase A (TRKA) receptor signaling by the nerve growth factor (NGF) or the neurosteroid dehydroepiandrosterone (DHEA) may combat neurodegeneration and regulate microglial function. In the present study, we synthesized a C-17-spiro-cyclopropyl DHEA derivative (ENT-A010), which was capable of activating TRKA. ENT-A010 protected PC12 cells against serum starvation-induced cell death, dorsal root ganglia (DRG) neurons against NGF deprivation-induced apoptosis and hippocampal neurons against Aβ-induced apoptosis. In addition, ENT-A010 pretreatment partially restored homeostatic features of microglia in the hippocampus of lipopolysaccharide (LPS)-treated mice, enhanced Aβ phagocytosis, and increased Ngf expression in microglia in vitro. In conclusion, the small molecule ENT-A010 elicited neuroprotective effects and modulated microglial function, thereby emerging as an interesting compound, which merits further study in the treatment of CNS disorders." @default.
- W4221090669 created "2022-04-03" @default.
- W4221090669 creator A5004023214 @default.
- W4221090669 creator A5017003587 @default.
- W4221090669 creator A5017035114 @default.
- W4221090669 creator A5022358527 @default.
- W4221090669 creator A5026258602 @default.
- W4221090669 creator A5037003034 @default.
- W4221090669 creator A5046777394 @default.
- W4221090669 creator A5047659161 @default.
- W4221090669 creator A5051830785 @default.
- W4221090669 creator A5067860976 @default.
- W4221090669 creator A5073294960 @default.
- W4221090669 creator A5076040685 @default.
- W4221090669 date "2022-03-09" @default.
- W4221090669 modified "2023-10-14" @default.
- W4221090669 title "ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses" @default.
- W4221090669 cites W1751678463 @default.
- W4221090669 cites W1841772591 @default.
- W4221090669 cites W1854317339 @default.
- W4221090669 cites W1889154171 @default.
- W4221090669 cites W1937256750 @default.
- W4221090669 cites W1973304468 @default.
- W4221090669 cites W1973756832 @default.
- W4221090669 cites W1975204297 @default.
- W4221090669 cites W1983319500 @default.
- W4221090669 cites W1983790532 @default.
- W4221090669 cites W1990520123 @default.
- W4221090669 cites W1994150565 @default.
- W4221090669 cites W1994814051 @default.
- W4221090669 cites W1998449125 @default.
- W4221090669 cites W2008350281 @default.
- W4221090669 cites W2015913347 @default.
- W4221090669 cites W2024989540 @default.
- W4221090669 cites W2028573458 @default.
- W4221090669 cites W2030789939 @default.
- W4221090669 cites W2042430625 @default.
- W4221090669 cites W2045402270 @default.
- W4221090669 cites W2046463428 @default.
- W4221090669 cites W2058030533 @default.
- W4221090669 cites W2063032404 @default.
- W4221090669 cites W2063312700 @default.
- W4221090669 cites W2063403392 @default.
- W4221090669 cites W2073496120 @default.
- W4221090669 cites W2077678165 @default.
- W4221090669 cites W2079576526 @default.
- W4221090669 cites W2080710662 @default.
- W4221090669 cites W2080899976 @default.
- W4221090669 cites W2081195776 @default.
- W4221090669 cites W2085185710 @default.
- W4221090669 cites W2090631968 @default.
- W4221090669 cites W2091604918 @default.
- W4221090669 cites W2096423240 @default.
- W4221090669 cites W2106942479 @default.
- W4221090669 cites W2122757904 @default.
- W4221090669 cites W2124490243 @default.
- W4221090669 cites W2124836944 @default.
- W4221090669 cites W2126402425 @default.
- W4221090669 cites W2126593848 @default.
- W4221090669 cites W2140572389 @default.
- W4221090669 cites W2145938600 @default.
- W4221090669 cites W2146919072 @default.
- W4221090669 cites W2156116786 @default.
- W4221090669 cites W2157383376 @default.
- W4221090669 cites W2167233884 @default.
- W4221090669 cites W2167279371 @default.
- W4221090669 cites W2168131206 @default.
- W4221090669 cites W2203955786 @default.
- W4221090669 cites W2220420147 @default.
- W4221090669 cites W2225188179 @default.
- W4221090669 cites W2416436748 @default.
- W4221090669 cites W2422726141 @default.
- W4221090669 cites W2482717739 @default.
- W4221090669 cites W2514075504 @default.
- W4221090669 cites W2514667278 @default.
- W4221090669 cites W2517534055 @default.
- W4221090669 cites W2520579003 @default.
- W4221090669 cites W2527645962 @default.
- W4221090669 cites W2528686449 @default.
- W4221090669 cites W2567278973 @default.
- W4221090669 cites W2620826105 @default.
- W4221090669 cites W2622807556 @default.
- W4221090669 cites W2754890392 @default.
- W4221090669 cites W2756079858 @default.
- W4221090669 cites W2775799858 @default.
- W4221090669 cites W2790861392 @default.
- W4221090669 cites W2793872352 @default.
- W4221090669 cites W2797914429 @default.
- W4221090669 cites W2804685648 @default.
- W4221090669 cites W2834934789 @default.
- W4221090669 cites W2884031535 @default.
- W4221090669 cites W2890847880 @default.
- W4221090669 cites W2891901614 @default.
- W4221090669 cites W2894203109 @default.
- W4221090669 cites W2903257803 @default.
- W4221090669 cites W2916019914 @default.
- W4221090669 cites W2924615230 @default.
- W4221090669 cites W2941354401 @default.