Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221095431> ?p ?o ?g. }
- W4221095431 endingPage "1157" @default.
- W4221095431 startingPage "1157" @default.
- W4221095431 abstract "Melanoma cells are notorious for their high plasticity and ability to switch back and forth between various melanoma cell states, enabling the adaptation to sub-optimal conditions and therapeutics. This phenotypic plasticity, which has gained more attention in cancer research, is proposed as a new paradigm for melanoma progression. In this review, we provide a detailed and deep comprehensive recapitulation of the complex spectrum of phenotype switching in melanoma, the key regulator factors, the various and new melanoma states, and corresponding signatures. We also present an extensive description of the role of epigenetic modifications (chromatin remodeling, methylation, and activities of long non-coding RNAs/miRNAs) and metabolic rewiring in the dynamic switch. Furthermore, we elucidate the main role of the crosstalk between the tumor microenvironment (TME) and oxidative stress in the regulation of the phenotype switching. Finally, we discuss in detail several rational therapeutic approaches, such as exploiting phenotype-specific and metabolic vulnerabilities and targeting components and signals of the TME, to improve the response of melanoma patients to treatments." @default.
- W4221095431 created "2022-04-03" @default.
- W4221095431 creator A5006230075 @default.
- W4221095431 creator A5010064853 @default.
- W4221095431 creator A5037892686 @default.
- W4221095431 creator A5048432907 @default.
- W4221095431 creator A5057255038 @default.
- W4221095431 creator A5088262611 @default.
- W4221095431 creator A5091892350 @default.
- W4221095431 date "2022-03-29" @default.
- W4221095431 modified "2023-10-13" @default.
- W4221095431 title "Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma" @default.
- W4221095431 cites W1163924930 @default.
- W4221095431 cites W1511793991 @default.
- W4221095431 cites W1530255485 @default.
- W4221095431 cites W1590243782 @default.
- W4221095431 cites W1640505003 @default.
- W4221095431 cites W1806952617 @default.
- W4221095431 cites W1966431971 @default.
- W4221095431 cites W1967135832 @default.
- W4221095431 cites W1967834264 @default.
- W4221095431 cites W1969621613 @default.
- W4221095431 cites W1976472776 @default.
- W4221095431 cites W1976603231 @default.
- W4221095431 cites W1977416216 @default.
- W4221095431 cites W1981040271 @default.
- W4221095431 cites W1981642691 @default.
- W4221095431 cites W1991488995 @default.
- W4221095431 cites W1992298824 @default.
- W4221095431 cites W1995103178 @default.
- W4221095431 cites W1999920543 @default.
- W4221095431 cites W2001348339 @default.
- W4221095431 cites W2004989092 @default.
- W4221095431 cites W2009897564 @default.
- W4221095431 cites W2010547812 @default.
- W4221095431 cites W2018433132 @default.
- W4221095431 cites W2033708806 @default.
- W4221095431 cites W2034984029 @default.
- W4221095431 cites W2045449074 @default.
- W4221095431 cites W2046452337 @default.
- W4221095431 cites W2051807533 @default.
- W4221095431 cites W2052005627 @default.
- W4221095431 cites W2052814985 @default.
- W4221095431 cites W2057893902 @default.
- W4221095431 cites W2057929910 @default.
- W4221095431 cites W2075240818 @default.
- W4221095431 cites W2078370873 @default.
- W4221095431 cites W2084906607 @default.
- W4221095431 cites W2085551560 @default.
- W4221095431 cites W2088487523 @default.
- W4221095431 cites W2089158037 @default.
- W4221095431 cites W2092823597 @default.
- W4221095431 cites W2095082648 @default.
- W4221095431 cites W2102448788 @default.
- W4221095431 cites W2105660237 @default.
- W4221095431 cites W2106391833 @default.
- W4221095431 cites W2106578635 @default.
- W4221095431 cites W2111897596 @default.
- W4221095431 cites W2112182696 @default.
- W4221095431 cites W2114903025 @default.
- W4221095431 cites W2121904350 @default.
- W4221095431 cites W2125408763 @default.
- W4221095431 cites W2140008764 @default.
- W4221095431 cites W2142219561 @default.
- W4221095431 cites W2151559508 @default.
- W4221095431 cites W2154833452 @default.
- W4221095431 cites W2154998222 @default.
- W4221095431 cites W2158880256 @default.
- W4221095431 cites W2186855780 @default.
- W4221095431 cites W2213492263 @default.
- W4221095431 cites W2259090596 @default.
- W4221095431 cites W2265959933 @default.
- W4221095431 cites W2276522360 @default.
- W4221095431 cites W2314266733 @default.
- W4221095431 cites W2337084923 @default.
- W4221095431 cites W2401641277 @default.
- W4221095431 cites W2404234615 @default.
- W4221095431 cites W2471321097 @default.
- W4221095431 cites W2513220633 @default.
- W4221095431 cites W2515256336 @default.
- W4221095431 cites W2537551256 @default.
- W4221095431 cites W2560396365 @default.
- W4221095431 cites W2573690182 @default.
- W4221095431 cites W2574813995 @default.
- W4221095431 cites W2577256604 @default.
- W4221095431 cites W2589525355 @default.
- W4221095431 cites W2594788856 @default.
- W4221095431 cites W2611545198 @default.
- W4221095431 cites W2613082041 @default.
- W4221095431 cites W2616637751 @default.
- W4221095431 cites W2680456958 @default.
- W4221095431 cites W2750530161 @default.
- W4221095431 cites W2751035971 @default.
- W4221095431 cites W2765099905 @default.
- W4221095431 cites W2767055857 @default.
- W4221095431 cites W2769278556 @default.
- W4221095431 cites W2783011222 @default.
- W4221095431 cites W2783974691 @default.