Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221099957> ?p ?o ?g. }
- W4221099957 endingPage "101616" @default.
- W4221099957 startingPage "101616" @default.
- W4221099957 abstract "Protein degraders are emerging as potent therapeutic tools to address neurological disorders and many complex diseases. It offered several key advantages, including the doses, drug resistance, and side effects over traditional occupancy-based inhibitors. Translation of chemical degraders into a clinical therapy for neurodegenerative disorders has a well-documented knowledge and resource gap. Researchers strive to develop clinical candidates employing chemical degraders' technologies, including hydrophobic tagging, molecular glues, proteolysis targeting chimeras (PROTACs), specific and nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent protein erasers (SNIPERs), autophagy targeted chimeras, and autophagosome-tethered compounds for targeted degradation of pathological markers in neurodegenerative disease. Herein, we examined the present state of chemical-mediated targeted protein degradation in the quest for medications to treat neurodegenerative diseases. We further identified targeted degraders under clinical development for neurodegenerative diseases summarizing pertinent discoveries guiding the future of degradation therapeutics. We also addressed the necessary pharmacological interventions needed to achieve unprecedented therapeutic efficacy and its associated challenges." @default.
- W4221099957 created "2022-04-03" @default.
- W4221099957 creator A5027341366 @default.
- W4221099957 creator A5064046988 @default.
- W4221099957 date "2022-06-01" @default.
- W4221099957 modified "2023-10-01" @default.
- W4221099957 title "Targeted protein degraders march towards the clinic for neurodegenerative diseases" @default.
- W4221099957 cites W1693283493 @default.
- W4221099957 cites W1979500993 @default.
- W4221099957 cites W1995079678 @default.
- W4221099957 cites W2003181166 @default.
- W4221099957 cites W2042479316 @default.
- W4221099957 cites W2049779453 @default.
- W4221099957 cites W2055568018 @default.
- W4221099957 cites W2068288454 @default.
- W4221099957 cites W2068455168 @default.
- W4221099957 cites W2134178604 @default.
- W4221099957 cites W2137771963 @default.
- W4221099957 cites W2145662716 @default.
- W4221099957 cites W2442498468 @default.
- W4221099957 cites W2506310918 @default.
- W4221099957 cites W2510806376 @default.
- W4221099957 cites W2516219238 @default.
- W4221099957 cites W2521142961 @default.
- W4221099957 cites W2527718275 @default.
- W4221099957 cites W2527752336 @default.
- W4221099957 cites W2553908226 @default.
- W4221099957 cites W2559947248 @default.
- W4221099957 cites W2580128191 @default.
- W4221099957 cites W2585495993 @default.
- W4221099957 cites W2599180871 @default.
- W4221099957 cites W2735605417 @default.
- W4221099957 cites W2740493003 @default.
- W4221099957 cites W2748160025 @default.
- W4221099957 cites W2758338369 @default.
- W4221099957 cites W2765415508 @default.
- W4221099957 cites W2767426216 @default.
- W4221099957 cites W2767856718 @default.
- W4221099957 cites W2784113553 @default.
- W4221099957 cites W2792557939 @default.
- W4221099957 cites W2801849928 @default.
- W4221099957 cites W2807101583 @default.
- W4221099957 cites W2886283685 @default.
- W4221099957 cites W2889301354 @default.
- W4221099957 cites W2895986434 @default.
- W4221099957 cites W2898621430 @default.
- W4221099957 cites W2902166673 @default.
- W4221099957 cites W2910045313 @default.
- W4221099957 cites W2916083029 @default.
- W4221099957 cites W2921294745 @default.
- W4221099957 cites W2921455446 @default.
- W4221099957 cites W2935329676 @default.
- W4221099957 cites W2938148420 @default.
- W4221099957 cites W2950911502 @default.
- W4221099957 cites W2953948138 @default.
- W4221099957 cites W2969666786 @default.
- W4221099957 cites W2972599807 @default.
- W4221099957 cites W2980052892 @default.
- W4221099957 cites W2982416093 @default.
- W4221099957 cites W2982548291 @default.
- W4221099957 cites W2984658219 @default.
- W4221099957 cites W2984957859 @default.
- W4221099957 cites W2990669650 @default.
- W4221099957 cites W2991059836 @default.
- W4221099957 cites W2995502746 @default.
- W4221099957 cites W3005464054 @default.
- W4221099957 cites W3008306561 @default.
- W4221099957 cites W3011413773 @default.
- W4221099957 cites W3020980264 @default.
- W4221099957 cites W3024382269 @default.
- W4221099957 cites W3025771928 @default.
- W4221099957 cites W3028901078 @default.
- W4221099957 cites W3033121834 @default.
- W4221099957 cites W3042456270 @default.
- W4221099957 cites W3046236678 @default.
- W4221099957 cites W3046680580 @default.
- W4221099957 cites W3083621646 @default.
- W4221099957 cites W3085706776 @default.
- W4221099957 cites W3091362147 @default.
- W4221099957 cites W3099442067 @default.
- W4221099957 cites W3120024969 @default.
- W4221099957 cites W3129200898 @default.
- W4221099957 cites W3131301786 @default.
- W4221099957 cites W3133645681 @default.
- W4221099957 cites W3137826907 @default.
- W4221099957 cites W3139364923 @default.
- W4221099957 cites W3152692563 @default.
- W4221099957 cites W3155742297 @default.
- W4221099957 cites W3158527646 @default.
- W4221099957 cites W3163870524 @default.
- W4221099957 cites W3174469972 @default.
- W4221099957 cites W3178041709 @default.
- W4221099957 cites W3180978278 @default.
- W4221099957 cites W3182522393 @default.
- W4221099957 cites W3195774465 @default.
- W4221099957 cites W3197741522 @default.
- W4221099957 cites W3205047146 @default.
- W4221099957 cites W4256169194 @default.