FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221104343> ?p ?o ?g. }

• W4221104343 endingPage "969" @default.
• W4221104343 startingPage "962" @default.
• W4221104343 abstract "Interleukin (IL)-12 and IL-23 are pro-inflammatory cytokines produced by dendritic cells (DCs) and associated with Psoriasis (Pso) and Psoriatic Arthritis (PsA) pathogenesis. Tofacitinib, a Janus kinase inhibitor, effectively suppresses inflammatory cascades downstream the IL-12/IL-23 axis in Pso and PsA patients. Here, we investigated whether Tofacitinib directly regulates IL-12/IL-23 production in DCs, and how this regulation reflects responses to Tofacitinib in Pso patients. We treated monocyte-derived dendritic cells and myeloid dendritic cells with Tofacitinib and stimulated cells with either lipopolysaccharide (LPS) or a combination of LPS and IFN-γ. We assessed gene expression by qPCR, obtained skin microarray and blood Olink data and clinical parameters of Pso patients treated with Tofacitinib from public data sets. Our results indicate that in DCs co-stimulated with LPS and IFN-γ, but not with LPS alone, Tofacitinib leads to the decreased expression of IL-23/IL-12 shared subunit IL12B (p40). In Tofacitinib-treated Pso patients, IL-12 expression and psoriasis area and severity index (PASI) are significantly reduced in patients with higher IFN-γ at baseline. These findings demonstrate for the first time that Tofacitinib suppresses IL-23/IL-12 shared subunit IL12B in DCs upon active IFN-γ signaling, and that Pso patients with higher IFN-γ baseline levels display improved clinical response after Tofacitinib treatment." @default.
• W4221104343 created "2022-04-03" @default.
• W4221104343 creator A5005185099 @default.
• W4221104343 creator A5008274472 @default.
• W4221104343 creator A5038553975 @default.
• W4221104343 creator A5046171667 @default.
• W4221104343 creator A5049215002 @default.
• W4221104343 creator A5049606459 @default.
• W4221104343 creator A5068737827 @default.
• W4221104343 creator A5071908846 @default.
• W4221104343 creator A5079495785 @default.
• W4221104343 date "2022-03-21" @default.
• W4221104343 modified "2023-09-30" @default.
• W4221104343 title "Suppression of IL‐12/IL‐23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon‐γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon‐driven diseases" @default.
• W4221104343 cites W1787578841 @default.
• W4221104343 cites W1962764685 @default.
• W4221104343 cites W1967744663 @default.
• W4221104343 cites W1967790310 @default.
• W4221104343 cites W1982535535 @default.
• W4221104343 cites W1997721794 @default.
• W4221104343 cites W1998647423 @default.
• W4221104343 cites W1999393388 @default.
• W4221104343 cites W2022901080 @default.
• W4221104343 cites W2070826648 @default.
• W4221104343 cites W2075577899 @default.
• W4221104343 cites W2091461229 @default.
• W4221104343 cites W2092374642 @default.
• W4221104343 cites W2093053402 @default.
• W4221104343 cites W2095522674 @default.
• W4221104343 cites W2098223746 @default.
• W4221104343 cites W2111796617 @default.
• W4221104343 cites W2121219094 @default.
• W4221104343 cites W2126874760 @default.
• W4221104343 cites W2134080373 @default.
• W4221104343 cites W2144714058 @default.
• W4221104343 cites W2147402696 @default.
• W4221104343 cites W2159546356 @default.
• W4221104343 cites W2168028214 @default.
• W4221104343 cites W2172036797 @default.
• W4221104343 cites W2195835569 @default.
• W4221104343 cites W2268374896 @default.
• W4221104343 cites W2312279372 @default.
• W4221104343 cites W2413887177 @default.
• W4221104343 cites W2580811839 @default.
• W4221104343 cites W2586850343 @default.
• W4221104343 cites W2615263582 @default.
• W4221104343 cites W2620033115 @default.
• W4221104343 cites W2625950214 @default.
• W4221104343 cites W2766846920 @default.
• W4221104343 cites W2781617771 @default.
• W4221104343 cites W2891620699 @default.
• W4221104343 cites W2897246274 @default.
• W4221104343 cites W2901898022 @default.
• W4221104343 cites W2915147916 @default.
• W4221104343 cites W2948288366 @default.
• W4221104343 cites W2963933189 @default.
• W4221104343 cites W2973019461 @default.
• W4221104343 cites W2986313081 @default.
• W4221104343 cites W4221104343 @default.
• W4221104343 doi "https://doi.org/10.1111/exd.14566" @default.
• W4221104343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35297512" @default.
• W4221104343 hasPublicationYear "2022" @default.
• W4221104343 type Work @default.
• W4221104343 citedByCount "2" @default.
• W4221104343 countsByYear W42211043432022 @default.
• W4221104343 countsByYear W42211043432023 @default.
• W4221104343 crossrefType "journal-article" @default.
• W4221104343 hasAuthorship W4221104343A5005185099 @default.
• W4221104343 hasAuthorship W4221104343A5008274472 @default.
• W4221104343 hasAuthorship W4221104343A5038553975 @default.
• W4221104343 hasAuthorship W4221104343A5046171667 @default.
• W4221104343 hasAuthorship W4221104343A5049215002 @default.
• W4221104343 hasAuthorship W4221104343A5049606459 @default.
• W4221104343 hasAuthorship W4221104343A5068737827 @default.
• W4221104343 hasAuthorship W4221104343A5071908846 @default.
• W4221104343 hasAuthorship W4221104343A5079495785 @default.
• W4221104343 hasBestOaLocation W42211043431 @default.
• W4221104343 hasConcept C112392421 @default.
• W4221104343 hasConcept C203014093 @default.
• W4221104343 hasConcept C2776178377 @default.
• W4221104343 hasConcept C2777575956 @default.
• W4221104343 hasConcept C2778170410 @default.
• W4221104343 hasConcept C2778690821 @default.
• W4221104343 hasConcept C2778886723 @default.
• W4221104343 hasConcept C2780564577 @default.
• W4221104343 hasConcept C71924100 @default.
• W4221104343 hasConcept C74172505 @default.
• W4221104343 hasConcept C8891405 @default.
• W4221104343 hasConcept C98274493 @default.
• W4221104343 hasConceptScore W4221104343C112392421 @default.
• W4221104343 hasConceptScore W4221104343C203014093 @default.
• W4221104343 hasConceptScore W4221104343C2776178377 @default.
• W4221104343 hasConceptScore W4221104343C2777575956 @default.
• W4221104343 hasConceptScore W4221104343C2778170410 @default.
• W4221104343 hasConceptScore W4221104343C2778690821 @default.
• W4221104343 hasConceptScore W4221104343C2778886723 @default.
• W4221104343 hasConceptScore W4221104343C2780564577 @default.
• W4221104343 hasConceptScore W4221104343C71924100 @default.

• next