Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221107416> ?p ?o ?g. }
- W4221107416 abstract "Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) present a global clinical threat, as these β-lactamases confer resistance to carbapenems and oxyimino-cephalosporins. Recent clinically identified KPC variants with substitutions at Ambler position D179, located in the Ω loop, are resistant to the β-lactam/β-lactamase inhibitor combination ceftazidime-avibactam, but susceptible to meropenem-vaborbactam." @default.
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- W4221107416 date "2022-04-19" @default.
- W4221107416 modified "2023-10-14" @default.
- W4221107416 title "Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam" @default.
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- W4221107416 doi "https://doi.org/10.1128/aac.02414-21" @default.
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- W4221107416 hasPublicationYear "2022" @default.
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