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- W4221107677 endingPage "377" @default.
- W4221107677 startingPage "361" @default.
- W4221107677 abstract "Solid tumours are composed of cancer cells characterised by genetic mutations that underpin the disease, but also contain a suite of genetically normal cells and the extracellular matrix (ECM). These two latter components are constituents of the tumour microenvironment (TME), and are key determinants of tumour biology and thereby the outcomes for patients. The tumour ECM has been the subject of intense research over the past two decades, revealing key biochemical and mechanobiological principles that underpin its role in tumour cell proliferation and survival. However, the ECM also strongly influences the genetically normal immune cells within the microenvironment, regulating not only their proliferation and survival, but also their differentiation and access to tumour cells. Here we review recent advances in our knowledge of how the ECM regulates the tumour immune microenvironment and vice versa, comparing normal skin wound healing to the pathological condition of tumour progression." @default.
- W4221107677 created "2022-04-03" @default.
- W4221107677 creator A5018055568 @default.
- W4221107677 creator A5018622474 @default.
- W4221107677 creator A5050393309 @default.
- W4221107677 date "2022-03-01" @default.
- W4221107677 modified "2023-09-30" @default.
- W4221107677 title "Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression" @default.
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