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- W4221107788 abstract "Abstract A metal and base‐free, operationally simple, and scalable multicomponent approach towards the synthesis of S ‐diarylmethane dithiocarbamates is reported. A range of structurally and electronically diverse p ‐quinone methides are shown to react with a variety of amines, and carbon disulfide to furnish corresponding dithiocarbamates in good to excellent yields under mild conditions. Furthermore, p ‐QMs embedded with aliphatic substituents are well accommodated. Importantly, these readily accessible compounds demonstrated promising anti‐proliferative activity in the low micromolar ranges in lung adenocarcinoma cells, reiterating the importance of the developed methodology. magnified image" @default.
- W4221107788 created "2022-04-03" @default.
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- W4221107788 date "2022-03-29" @default.
- W4221107788 modified "2023-10-16" @default.
- W4221107788 title "Multicomponent Synthesis of Biologically Relevant <i>S</i>‐Diarylmethane Dithiocarbamates Using <i>p</i>‐Quinone Methides" @default.
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- W4221107788 doi "https://doi.org/10.1002/adsc.202200029" @default.
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