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- W4221107848 abstract "Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen-associated or host-derived elements. Although four IRAK family members [IRAK1, 2, 3 (i.e., IRAK-M), and 4] are involved in TLR and IL-1R signaling pathways, IL-1R > IRAK1 signaling appears to be the most studied pathway, with sufficient evidence to support its central role linking the innate immune response to the pathogenesis of various diseases, including cancers, metabolic disorders, and non-infectious immune disorders. However, IRAK1's involvement in cardiovascular diseases was only recently revealed and the detailed mechanism underling the pathogenesis of cardiovascular diseases, such as atherosclerosis, myocardial infarction, and heart failure (all non-infectious disorders), remains largely unknown with very limited publications to date. This review aims to summarize the overall roles of the IRAK family, especially IRAK1, in mediating the development of cardiovascular diseases." @default.
- W4221107848 created "2022-04-03" @default.
- W4221107848 creator A5028330071 @default.
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- W4221107848 date "2022-03-12" @default.
- W4221107848 modified "2023-10-05" @default.
- W4221107848 title "Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases" @default.
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- W4221107848 cites W1987976516 @default.
- W4221107848 cites W1988150687 @default.
- W4221107848 cites W1990341072 @default.
- W4221107848 cites W1998641623 @default.
- W4221107848 cites W2002262609 @default.
- W4221107848 cites W2012760729 @default.
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- W4221107848 cites W2014054401 @default.
- W4221107848 cites W2014120138 @default.
- W4221107848 cites W2030914021 @default.
- W4221107848 cites W2033925114 @default.
- W4221107848 cites W2034287596 @default.
- W4221107848 cites W2046140449 @default.
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- W4221107848 cites W2054356692 @default.
- W4221107848 cites W2060351820 @default.
- W4221107848 cites W2075860675 @default.
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- W4221107848 doi "https://doi.org/10.31083/j.rcm2303097" @default.
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